Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000275.1:
Cluster 1Polyketide113123

BGC0000275, tetracenomycin biosynthetic gene cluster from Streptomyces glaucescens. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: tetracenomycin C
SMILES string: Copy to clipboard
Molecular formula: C23H20O11
Exact molecular mass: 472.1 Da (None)
Molecular activity: Antibacterial, Cytotoxic, Other

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Anthracycline (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
AAA67515.1
Genes involved in folding/cyclization:
AAA67518.1

Gene cluster description

tetracenomycin (BGC0000275). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank M80674, positions 59-12211. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Heterologous expression, Gene expression correlated with compound production, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Guohui Pan (The Scripps Research Institute)

Literature references

1. Summers RG et al. (1992) Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase. J Bacteriol 174(6):1810-20.
2. Guilfoile PG, Hutchinson CR. (1992) Sequence and transcriptional analysis of the Streptomyces glaucescens tcmAR tetracenomycin C resistance and repressor gene loci. J Bacteriol 174(11):3651-8.
3. Shen B, Hutchinson CR. (1994) Triple hydroxylation of tetracenomycin A2 to tetracenomycin C in Streptomyces glaucescens. Overexpression of the tcmG gene in Streptomyces lividans and characterization of the tetracenomycin A2 oxygenase. J Biol Chem 269(48):30726-33.
4. Summers RG et al. (1993) The tcmVI region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase. J Bacteriol 175(23):7571-80.
5. Hutchinson CR. (1997) Biosynthetic Studies of Daunorubicin and Tetracenomycin C. Chem Rev 97(7):2525-2536.
6. Bao W et al. (1998) Reconstitution of the iterative type II polyketide synthase for tetracenomycin F2 biosynthesis. Biochemistry 37(22):8132-8. doi: 10.1021/bi980466i.