BGC0000275: tetracenomycin C biosynthetic gene cluster from Streptomyces glaucescens
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Location: 1 - 13,123 nt. (total: 13,123 nt).
This entry is originally from NCBI GenBank M80674.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
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Biosynthesis
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0000275
Short description tetracenomycin C biosynthetic gene cluster from Streptomyces glaucescens
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
Loci
M80674.1
via Knock-out studies, Enzymatic assays, Heterologous expression, Gene expression correlated with compound production
Compounds
  • tetracenomycin C
Species Streptomyces glaucescens [taxonomy]
References
Chemical products information
tetracenomycin C Evidence:
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C23H20O11
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAA67508.1
  • tcmR
 59 - >742 (-) tetracenomycin C resistance and export gene repressor
  • Regulation
  • Knock-out
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  • AAA67509.1
  • tcmA
 878 - 2494 (+) tetracenomycin C resistance and export protein
  • Transport
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  • AAA67510.1
  • tcmP
 2609 - >3424 (-) O-methyltransferase
  • Tailoring
  • Activity assay
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  • AAA67511.1
  • tcmG
 3954 - 5639 (+) hydroxylase
  • Tailoring
  • Activity assay
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  • AAA67512.1
  • tcmH
 5644 - 5982 (+) monooxygenase
  • Tailoring
  • Activity assay
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  • AAA67513.1
  • tcmI
 5985 - 6314 (+) cyclase
  • Scaffold biosynthesis
  • Activity assay
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  • AAA67514.1
  • tcmJ
 6328 - 6777 (+) predicted protein
  • Scaffold biosynthesis
  • Knock-out Activity assay
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  • AAA67515.1
  • tcmK
 6779 - 8059 (+) beta-ketoacyl synthase
  • Scaffold biosynthesis
  • Knock-out Activity assay
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  • AAA67516.1
  • tcmL
 8056 - 9285 (+) beta-ketoacyl synthase,chain length factor
  • Scaffold biosynthesis
  • Knock-out Activity assay
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  • AAA67517.1
  • tcmM
 9358 - 9609 (+) acyl carrier protein
  • Scaffold biosynthesis
  • Knock-out Activity assay
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  • AAA67518.1
  • tcmN
 9611 - 11095 (+) aromatase/cyclase
  • Scaffold biosynthesis
  • Knock-out Activity assay
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  • AAA67519.1
  • tcmO
 11192 - 12211 (+) O-methyltransferase
  • Tailoring
  • Activity assay
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Biosynthesis information
Annotation changelog

Entry version: 3

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 1

Date
Changes
Submitters
Reviewers
2015-06-12
Submitted
  • (ID: HPZ6LL7T2WJIC44FKRYGWFQ6)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
Detailed domain annotation
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