BGC0000279: xantholipin biosynthetic gene cluster from Streptomyces flavogriseus
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Location: 1 - 52,255 nt. (total: 52,255 nt).
This entry is originally from NCBI GenBank GQ421798.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000279
Short description xantholipin biosynthetic gene cluster from Streptomyces flavogriseus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
GQ421798.1
via
Compounds
  • xantholipin
Species Streptomyces flavogriseus [taxonomy]
References
Chemical products information
xantholipin Evidence: NMR [1]
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C27H18Cl1N1O10
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADE22275.1
  • xanY1
 1 - 1419 (-) putative adenosylhomocysteinase
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    • ADE22276.1
    • xanY2
    		 1397 - 2299 (-) 5,10-methylenetetrahydrofolate reductase
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      • ADE22277.1
      • xanY3
      		 2305 - 5802 (-) methionine synthase
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        • ADE22278.1
        • xanY4
        		 5799 - 6791 (-) carbohydrate kinase
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          • ADE22279.1
          • xanY5
          		 6817 - 8037 (-) S-adenosylmethionine synthetase
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            • ADE22280.1
            • xanO1
            		 8146 - 8583 (-) putative oxygenase
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              • ADE22281.1
              • xanS1
              		 8580 - 9803 (-) putative dehydrogenase
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                • ADE22282.1
                • xanJ
                		 9867 - 10595 (+) hypothetical protein
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                  • ADE22283.1
                  • xanP
                  		 10592 - 12211 (+) putative spore coat protein
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                    • ADE22284.1
                    • xanG
                    		 12379 - 13554 (+) putative inactive gylcosyltransferase
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                      • ADE22285.1
                      • xanA
                      		 13542 - 15386 (+) putative asparagine synthase
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                        • ADE22286.1
                        • xanR1
                        		 15392 - 16075 (+) putative transcriptional regulator
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                          • ADE22287.1
                          • xanO2
                          		 16114 - 17316 (+) putative cytochrome P450 hydroxylase
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                            • ADE22288.1
                            • xanK
                            		 17333 - 17602 (+) putative 3Fe-S ferredoxin
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                              • ADE22289.1
                              • xanU
                              		 17599 - 19728 (+) putative antibiotic transporter
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                                • ADE22290.1
                                • xanO3
                                		 19908 - 21086 (+) FAD-binding monooxygenase
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                                  • ADE22291.1
                                  • xanL
                                  		 21147 - 21707 (-) putative lactoylglutathione lyase
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                                    • ADE22292.1
                                    • xanH
                                    		 22057 - 23472 (+) flavin-dependent halogenase
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                                      • ADE22293.1
                                      • xanQ
                                      		 23469 - 25070 (+) putative peptide transporter
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                                        • ADE22294.1
                                        • xanM1
                                        		 25067 - 26086 (+) putative O-methyltransferase
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                                          • ADE22295.1
                                          • xanZ1
                                          		 26651 - 27508 (+) putative F420-dependent reductase
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                                            • ADE22296.1
                                            • xanN
                                            		 27593 - 28888 (-) putative integral membrane ion antiporter
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                                              • ADE22297.1
                                              • xanW
                                              		 28985 - 29473 (-) hypothetical protein
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                                                • ADE22298.1
                                                • xanR2
                                                		 29600 - 30061 (+) putative transcriptional regulator
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                                                  • ADE22299.1
                                                  • xanM2
                                                  		 30083 - 31105 (-) putative O-methyltransferase
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                                                    • ADE22300.1
                                                    • xanO4
                                                    		 31120 - 32742 (-) putative FAD-binding monooxygenase
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                                                      • ADE22301.1
                                                      • xanM3
                                                      		 33084 - 34118 (+) putative methyltransferase
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                                                        • ADE22302.1
                                                        • xanO5
                                                        		 34203 - 35798 (+) putative FAD-binding monooxygenase
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                                                          • ADE22303.1
                                                          • xanS2
                                                          		 35868 - 36554 (+) putative short-chain dehydrogenase/reductase SDR
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                                                            • ADE22304.1
                                                            • xanZ2
                                                            		 36759 - 37667 (-) putative oxidoreductase
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                                                              • ADE22305.1
                                                              • xanR3
                                                              		 37715 - 38722 (+) putative transcriptional regulator
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                                                                • ADE22306.1
                                                                • xanB1
                                                                		 38844 - 40187 (-) biotin carboxylase
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                                                                  • ADE22307.1
                                                                  • xanB2
                                                                  		 40190 - 40714 (-) biotin carboxyl carrier protein
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                                                                    • ADE22308.1
                                                                    • xanB3
                                                                    		 40774 - 42468 (-) carboxyl transferase
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                                                                      • ADE22309.1
                                                                      • xanO6
                                                                      		 42546 - 42857 (-) putative monooxygenase
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                                                                        • ADE22310.1
                                                                        • xanO7
                                                                        		 42847 - 43194 (-) putative monooxygenase
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                                                                          • ADE22311.1
                                                                          • xanZ3
                                                                          		 43194 - 43946 (-) putative 3-oxoacyl-ACP reductase
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                                                                            • ADE22312.1
                                                                            • xanO8
                                                                            		 43970 - 44431 (-) putative monooxygenase
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                                                                              • ADE22313.1
                                                                              • xanC1
                                                                              		 44442 - 44909 (-) putative polyketide cyclase
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                                                                                • ADE22314.1
                                                                                • xanE
                                                                                		 45017 - 46303 (-) putative polyketide beta-ketoacyl synthase beta
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                                                                                  • ADE22315.1
                                                                                  • xanF
                                                                                  		 46306 - 47583 (-) putative polyketide beta-ketoacyl synthase alpha
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                                                                                    • ADE22316.1
                                                                                    • xanC2
                                                                                    		 47580 - 48014 (-) putative polyketide cyclase
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                                                                                      • ADE22317.1
                                                                                      • xanT
                                                                                      		 48198 - 48584 (+) CurD-like protein
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                                                                                        • ADE22318.1
                                                                                        • xanO9
                                                                                        		 48596 - 50014 (+) oxidase-like protein
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                                                                                          • ADE22319.1
                                                                                          • xanO10
                                                                                          		 50067 - 50513 (-) putative monooxygenase
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                                                                                            • ADE22320.1
                                                                                            • xanV
                                                                                            		 50528 - 50908 (-) hypothetical protein
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                                                                                              • ADE22321.1
                                                                                              • xanZ4
                                                                                              		 50908 - 51663 (-) 3-oxoacyl-ACP reductase
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                                                                                                • ADE22322.1
                                                                                                • xanD
                                                                                                		 51660 - 51920 (-) acyl carrier protein
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                                                                                                  • ADE22323.1
                                                                                                  • xanC3
                                                                                                  		 51917 - 52255 (-) putative polyketide cyclase
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                                                                                                    Biosynthesis information
                                                                                                    Annotation changelog

                                                                                                    Entry version: next

                                                                                                    Date
                                                                                                    Changes
                                                                                                    Submitters
                                                                                                    Reviewers
                                                                                                    2024-05-14
                                                                                                    MIBiG v4 annotathon
                                                                                                    • (ID: NHJ6M55E7ZEHUFNMEG4QIZWY)
                                                                                                    • (ID: 4ZBJCWV5NZUBDJXCSIV4TKIA)
                                                                                                    • (ID: EMAUK5TYS6O5PLPCDCIRFTNF)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                    Entry version: 4

                                                                                                    Date
                                                                                                    Changes
                                                                                                    Submitters
                                                                                                    Reviewers
                                                                                                    2022-10-07
                                                                                                    Update chemical activity to schema version 2.11
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                    Entry version: 3

                                                                                                    Date
                                                                                                    Changes
                                                                                                    Submitters
                                                                                                    Reviewers
                                                                                                    2022-09-15
                                                                                                    Updated bioactivity data
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                    Entry version: 2

                                                                                                    Date
                                                                                                    Changes
                                                                                                    Submitters
                                                                                                    Reviewers
                                                                                                    2019-10-16
                                                                                                    Migrated from v1.4
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    2019-10-16
                                                                                                    Updated compound(s) information (NPAtlas curation)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                    Entry version: 1

                                                                                                    Date
                                                                                                    Changes
                                                                                                    Submitters
                                                                                                    Reviewers
                                                                                                    2015-06-12
                                                                                                    Submitted
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    Detailed domain annotation
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