BGC0000306: arylomycin biosynthetic gene cluster from Streptomyces filamentosus NRRL 11379
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Location: 6,273,710 - 6,304,320 nt. (total: 30,611 nt).
This entry is originally from NCBI GenBank ABYX02000001.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000306
Short description arylomycin biosynthetic gene cluster from Streptomyces filamentosus NRRL 11379
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
ABYX02000001.1
6273710 - 6304320
via
Compounds
  • arylomycin
Species Streptomyces filamentosus NRRL 11379 [taxonomy]
References
Chemical products information
arylomycin Evidence:
Copy SMILES
C46H68N6O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SSIG_07966
  • EWS95122.1
 6273710 - 6284167 (-) hypothetical protein
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    • SSIG_05822
    • EWS95123.1
    		 6284796 - 6285965 (+) hypothetical protein
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      • SSIG_05823
      • EWS95124.1
      		 6286024 - 6298917 (+) hypothetical protein
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        • SSIG_05824
        • EWS95125.1
        		 6298943 - 6299164 (+) MbtH domain-containing protein
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          • SSIG_05825
          • EWS95126.1
          		 6299212 - 6300276 (+) 4-hydroxyphenylpyruvate dioxygenase
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            • SSIG_05826
            • EWS95127.1
            		 6300273 - 6301388 (+) L-lactate oxidase
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              • SSIG_05827
              • EWS95128.1
              		 6301381 - 6302730 (+) GntR family transcriptional regulator
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                • SSIG_05828
                • EWS95129.1
                		 6302792 - 6303664 (+) heme ABC exporter, ATP-binding protein CcmA
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                  • SSIG_05829
                  • EWS95130.1
                  		 6303697 - 6304320 (+) hypothetical protein
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                    Biosynthesis information

                    Biosynthetic modules

                    Name
                    1
                    Type
                    nrps-type1
                    Genes
                    SSIG_07966
                    Substrates
                    serine (evidence: Structure-based inference)
                    Integrated Monomers
                    Domains
                    condensation (Starter), adenylation, epimerase, methyltransferase
                    Name
                    2
                    Type
                    nrps-type1
                    Genes
                    SSIG_07966 SSIG_05823
                    Substrates
                    alanine (evidence: Structure-based inference)
                    Integrated Monomers
                    Domains
                    condensation, adenylation, epimerase
                    Name
                    3
                    Type
                    nrps-type1
                    Genes
                    SSIG_05823
                    Substrates
                    4-hydroxyphenylglycine (evidence: Structure-based inference [1])
                    Integrated Monomers
                    Domains
                    condensation (LCL), adenylation, methyltransferase
                    Name
                    4
                    Type
                    nrps-type1
                    Genes
                    SSIG_05823
                    Substrates
                    alanine (evidence: Structure-based inference)
                    Integrated Monomers
                    Domains
                    condensation (LCL), adenylation
                    Name
                    5
                    Type
                    nrps-type1
                    Genes
                    SSIG_05823
                    Substrates
                    tyrosine (evidence: Structure-based inference [1])
                    Integrated Monomers
                    Domains
                    condensation (LCL), adenylation
                    Annotation changelog

                    Entry version: 4

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-10-07
                    Update chemical activity to schema version 2.11
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 3

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-09-15
                    Corrected NRP module activity
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Updated NRP substrate specificities
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 2

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2019-10-16
                    Migrated from v1.4
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 1

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2015-06-12
                    Submitted
                    • (ID: UK5BZZ5BLXFR5LGS2GITT5IB)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    Detailed domain annotation
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