BGC0000325: coelichelin biosynthetic gene cluster from Streptomyces coelicolor A3(2)
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Location: 510,823 - 533,448 nt. (total: 22,626 nt).
This entry is originally from NCBI GenBank AL645882.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000325
Short description coelichelin biosynthetic gene cluster from Streptomyces coelicolor A3(2)
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AL645882.2
510823 - 533448
via
Compounds
  • coelichelin
Species Streptomyces coelicolor A3(2) [taxonomy]
References
Chemical products information
coelichelin Evidence:
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C21H39N7O11
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAB53319.1
  • SCO0489
 510823 - 511035 (-) conserved hypothetical protein
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    • CAB53320.1
    • SCO0490
    		 511124 - 512215 (+) putative esterase
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      • CAB53321.1
      • SCO0491
      		 512302 - 513924 (-) putative ABC transporter transmembrane protein
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        • CAB53322.1
        • SCO0492
        		 513989 - 524920 (-) putative peptide synthetase
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          • CAB53323.1
          • SCO0493
          		 524978 - 526783 (-) putative ABC-transporter transmembrane protein
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            • CAB53324.1
            • SCO0494
            		 526786 - 527838 (-) putative iron-siderophore binding lipoprotein
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              • CAB53325.1
              • SCO0495
              		 527889 - 528752 (-) putative iron-siderophore ABC-transporter ATP-binding protein
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                • CAB53326.1
                • SCO0496
                		 528791 - 529897 (-) putative iron-siderophore permease transmembrane protein
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                  • CAB53327.1
                  • SCO0497
                  		 529894 - 530970 (-) putative iron-siderophore permease transmembrane protein
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                    • CAB53328.1
                    • SCO0498
                    		 530970 - 532325 (-) putative peptide monooxygenase
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                      • CAB53329.1
                      • SCO0499
                      		 532501 - 533448 (+) putative formyltransferase
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                        Biosynthesis information

                        Biosynthetic modules

                        Name
                        Unk01
                        Type
                        nrps-type1
                        Genes
                        SCO0492
                        Substrates
                        N5-formyl-N5-hydroxyornithine (evidence: Structure-based inference [2])
                        Integrated Monomers
                        Domains
                        adenylation
                        Name
                        Unk02
                        Type
                        nrps-type1
                        Genes
                        SCO0492
                        Substrates
                        threonine (evidence: Structure-based inference [1])
                        Integrated Monomers
                        Domains
                        adenylation
                        Name
                        Unk03
                        Type
                        nrps-type1
                        Genes
                        SCO0492
                        Substrates
                        N5-hydroxyornithine (evidence: Structure-based inference [3])
                        Integrated Monomers
                        Domains
                        adenylation
                        Annotation changelog

                        Entry version: 4

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-10-07
                        Update chemical activity to schema version 2.11
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 3

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-09-15
                        Updated bioactivity data
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-09-15
                        Added NRP substrate specificities
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 2

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2019-10-16
                        Migrated from v1.4
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2019-10-16
                        Updated compound(s) information (NPAtlas curation)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 1

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2015-06-12
                        Submitted
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        Detailed domain annotation
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