BGC0000325 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000325 (Streptomyces coelicolor A3(2))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	22,626	scabichelin	NRP	60%

BGC0000325 - Region 1 - NRPS

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Location: 1 - 22,626 nt. (total: 22,626 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 22,627
Label		BGC0000325

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000325.1	0.89	NRP	coelichelin	Streptomyces coelicolor A3(2)
BGC0000457.1	0.30	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001479.1	0.27	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001825.1	0.27	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001873.1	0.25	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0000321.1	0.25	NRP	chaetocin	Collariella virescens
BGC0001671.1	0.25	NRP	monobactam	Agrobacterium tumefaciens
BGC0000357.1	0.23	NRP	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001833.1	0.23	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001240.1	0.23	NRP	serinocyclin A, serinocyclin B	Metarhizium robertsii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000325.1	0.96	NRP	coelichelin	Streptomyces coelicolor A3(2)
BGC0000457.1	0.64	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001479.1	0.61	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001825.1	0.60	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001873.1	0.59	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0000321.1	0.58	NRP	chaetocin	Collariella virescens
BGC0001671.1	0.58	NRP	monobactam	Agrobacterium tumefaciens
BGC0000357.1	0.57	NRP	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001833.1	0.56	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001240.1	0.56	NRP	serinocyclin A, serinocyclin B	Metarhizium robertsii

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 22626:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-orn - D-thr - orn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

SCO0492

Search NORINE for peptide: strict or relaxed

AMP-binding (142..540): orn

NRPSPredictor2: orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: orn, lys, arg
Small clusters prediction:: orn, horn
Single AA prediction:: orn

Stachelhaus prediction details:

Stachelhaus sequence:: DINYWGGIGK
Nearest Stachelhaus code:: orn
Stachelhaus code match:: 100% (strong)

AMP-binding (1625..2039): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (3060..3462): orn

NRPSPredictor2: orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: orn, lys, arg
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMwNLGLINK
Nearest Stachelhaus code:: orn
Stachelhaus code match:: 90% (moderate)