BGC0000327: netropsin biosynthetic gene cluster from Streptomyces ambofaciens ATCC 23877
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Location: 1,082,965 - 1,112,107 nt. (total: 29,143 nt).
This entry is originally from NCBI GenBank AM238664.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000327
Short description netropsin biosynthetic gene cluster from Streptomyces ambofaciens ATCC 23877
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AM238664.2
1082965 - 1112107
via
Compounds
  • netropsin
Species Streptomyces ambofaciens ATCC 23877 [taxonomy]
References
Chemical products information
netropsin Evidence:
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C18H26N10O3
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SAMR0900
  • CAJ88609.1
 1082965 - 1083330 (-) putative nonribosomal peptide synthetase
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    • SAMR0901
    • CAJ88610.1
    		 1083388 - 1086591 (-) putative non-ribosomal peptide synthetase
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      • SAMR0902
      • CAJ88611.1
      		 1086588 - 1087634 (-) putative dehydrogenase
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        • SAMR0903
        • CAJ88612.1
        		 1087631 - 1088968 (-) putative non ribosomal peptide synthetase
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          • SAMR0904
          • CAJ88613.1
          		 1088992 - 1089765 (-) putative SAM-dependent methyltransferase
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            • SAMR0905
            • CAJ88614.1
            		 1089805 - 1090578 (-) putative metal-dependent hydrolase of the TIM-barrel fold
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              • SAMR0906
              • CAJ88615.1
              		 1090710 - 1092635 (-) conserved hypothetical protein
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                • SAMR0907
                • CAJ88616.1
                		 1092623 - 1093768 (-) putative lipopolysaccharide biosynthesis protein
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                  • SAMR0908
                  • CAJ88617.1
                  		 1093765 - 1094529 (-) putative nucleoside-diphosphate-sugar pyrophosphorylase
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                    • SAMR0909
                    • CAJ88618.1
                    		 1094526 - 1095542 (-) putative glycosyl transferase
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                      • SAMR0910
                      • CAJ88619.1
                      		 1095605 - 1096588 (-) putative epimerase
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                        • SAMR0911
                        • CAJ88620.1
                        		 1096581 - 1097852 (-) putative UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase
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                          • SAMR0912
                          • CAJ88621.1
                          		 1097935 - 1099068 (-) hypothetical protein
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                            • SAMR0913
                            • CAJ88622.1
                            		 1099116 - 1099937 (-) putative creatinase
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                              • SAMR0914
                              • CAJ88623.1
                              		 1099948 - 1100841 (-) putative hihydroorotate dehydrogenase
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                                • SAMR0915
                                • CAJ88624.1
                                		 1100838 - 1101383 (-) conserved hypothetical protein
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                                  • SAMR0916
                                  • CAJ88625.1
                                  		 1101380 - 1102828 (-) putative aldehyde dehydrogenase
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                                    • SAMR0917
                                    • CAJ88626.1
                                    		 1103647 - 1105059 (-) putative non-ribosomal antibiotic-related peptide synthase
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                                      • SAMR0918
                                      • CAJ88627.1
                                      		 1105399 - 1106070 (-) putative two component response regulator-like
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                                        • SAMR0919
                                        • CAJ88628.1
                                        		 1106811 - 1108670 (+) putative netropsin resistance protein subunit 1
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                                          • SAMR0920
                                          • CAJ88629.1
                                          		 1108670 - 1110505 (+) putative netropsin resistance protein subunit 2
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                                            • SAMR0921
                                            • CAJ88630.1
                                            		 1110509 - 1112107 (+) putative acyl-CoA synthetase
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                                              Biosynthesis information

                                              Biosynthetic modules

                                              Name
                                              Unk01
                                              Type
                                              nrps-type1
                                              Genes
                                              SAMR0901
                                              Substrates
                                              guanidinoacetic acid (evidence: Structure-based inference, ATP-PPi exchange assay)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk02
                                              Type
                                              nrps-type1
                                              Genes
                                              SAMR0921
                                              Substrates
                                              4-acetamidopyrrole-2-carboxylic acid (evidence: Structure-based inference, ATP-PPi exchange assay)
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Annotation changelog

                                              Entry version: 4

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-10-07
                                              Update chemical activity to schema version 2.11
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 3

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-09-15
                                              Updated bioactivity data
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              2022-09-15
                                              Added NRP substrate specificities
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 2

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2019-10-16
                                              Migrated from v1.4
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              2019-10-16
                                              Updated compound(s) information (NPAtlas curation)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 1

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2015-06-12
                                              Submitted
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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