BGC0000327: netropsin biosynthetic gene cluster from Streptomyces ambofaciens ATCC 23877
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 1,082,965 - 1,112,107 nt. (total: 29,143 nt).
This entry is originally from NCBI GenBank AM238664.2.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000327
Short description netropsin biosynthetic gene cluster from Streptomyces ambofaciens ATCC 23877
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AM238664.2
Compounds
  • netropsin
Species Streptomyces ambofaciens ATCC 23877 [taxonomy]
References
Chemical products information
netropsin
Copy SMILES
C18H26N10O3
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SAMR0900
  • CAJ88609.1
1082965 - 1083330 (-) putative nonribosomal peptide synthetase
copy AA seq
copy Nt seq
  • SAMR0901
  • CAJ88610.1
1083388 - 1086591 (-) putative non-ribosomal peptide synthetase
copy AA seq
copy Nt seq
  • SAMR0902
  • CAJ88611.1
1086588 - 1087634 (-) putative dehydrogenase
copy AA seq
copy Nt seq
  • SAMR0903
  • CAJ88612.1
1087631 - 1088968 (-) putative non ribosomal peptide synthetase
copy AA seq
copy Nt seq
  • SAMR0904
  • CAJ88613.1
1088992 - 1089765 (-) putative SAM-dependent methyltransferase
copy AA seq
copy Nt seq
  • SAMR0905
  • CAJ88614.1
1089805 - 1090578 (-) putative metal-dependent hydrolase of the TIM-barrel fold
copy AA seq
copy Nt seq
  • SAMR0906
  • CAJ88615.1
1090710 - 1092635 (-) conserved hypothetical protein
copy AA seq
copy Nt seq
  • SAMR0907
  • CAJ88616.1
1092623 - 1093768 (-) putative lipopolysaccharide biosynthesis protein
copy AA seq
copy Nt seq
  • SAMR0908
  • CAJ88617.1
1093765 - 1094529 (-) putative nucleoside-diphosphate-sugar pyrophosphorylase
copy AA seq
copy Nt seq
  • SAMR0909
  • CAJ88618.1
1094526 - 1095542 (-) putative glycosyl transferase
copy AA seq
copy Nt seq
  • SAMR0910
  • CAJ88619.1
1095605 - 1096588 (-) putative epimerase
copy AA seq
copy Nt seq
  • SAMR0911
  • CAJ88620.1
1096581 - 1097852 (-) putative UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase
copy AA seq
copy Nt seq
  • SAMR0912
  • CAJ88621.1
1097935 - 1099068 (-) hypothetical protein
copy AA seq
copy Nt seq
  • SAMR0913
  • CAJ88622.1
1099116 - 1099937 (-) putative creatinase
copy AA seq
copy Nt seq
  • SAMR0914
  • CAJ88623.1
1099948 - 1100841 (-) putative hihydroorotate dehydrogenase
copy AA seq
copy Nt seq
  • SAMR0915
  • CAJ88624.1
1100838 - 1101383 (-) conserved hypothetical protein
copy AA seq
copy Nt seq
  • SAMR0916
  • CAJ88625.1
1101380 - 1102828 (-) putative aldehyde dehydrogenase
copy AA seq
copy Nt seq
  • SAMR0917
  • CAJ88626.1
1103647 - 1105059 (-) putative non-ribosomal antibiotic-related peptide synthase
copy AA seq
copy Nt seq
  • SAMR0918
  • CAJ88627.1
1105399 - 1106070 (-) putative two component response regulator-like
copy AA seq
copy Nt seq
  • SAMR0919
  • CAJ88628.1
1106811 - 1108670 (+) putative netropsin resistance protein subunit 1
copy AA seq
copy Nt seq
  • SAMR0920
  • CAJ88629.1
1108670 - 1110505 (+) putative netropsin resistance protein subunit 2
copy AA seq
copy Nt seq
  • SAMR0921
  • CAJ88630.1
1110509 - 1112107 (+) putative acyl-CoA synthetase
copy AA seq
copy Nt seq
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
SAMR0901
Module ?
Specificity: guanidinoacetic acid
Evidence for specificity:
  • Structure-based inference
  • ATP-PPi exchange assay
SAMR0921
Module ?
Specificity: 4-acetamidopyrrole-2-carboxylic acid
Evidence for specificity:
  • Structure-based inference
  • ATP-PPi exchange assay
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.