BGC0000335: cystomanamide A biosynthetic gene cluster from Cystobacter fuscus
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Location: 1 - 37,509 nt. (total: 37,509 nt).
This entry is originally from NCBI GenBank KJ710244.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000335
Short description cystomanamide A biosynthetic gene cluster from Cystobacter fuscus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
KJ710244.1
via
Compounds
  • cystomanamide A
  • cystomanamide B
  • cystomanamide C
  • cystomanamide D
Species Cystobacter fuscus [taxonomy]
References
Chemical products information
cystomanamide A Evidence:
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C28H44N6O9
Chemical database entries
NPAtlas
cystomanamide B Evidence:
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C40H57N7O14
Chemical database entries
NPAtlas
cystomanamide C Evidence:
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C34H54N6O14
Chemical database entries
NPAtlas
cystomanamide D Evidence:
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C34H54N6O13
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AID65218.1
 164 - 1054 (+) JmjC domain-containing protein
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    • AID65219.1
    		 1159 - 2589 (+) beta-lactamase
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      • AID65220.1
      		 2682 - 3968 (+) beta-lactamase
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        • AID65221.1
        		 3972 - 5441 (+) beta-lactamase
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          • AID65222.1
          • ctmA
          		 5528 - 18073 (+) putative aspartate racemase
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            • AID65223.1
            • ctmB
            		 18088 - 19098 (+) putative taurine catabolism dioxygenase
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              • AID65224.1
              • ctmC
              		 19123 - 26763 (+) nonribosomal peptide synthetase
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                • AID65225.1
                • ctmD
                		 26793 - 35432 (+) nonribosomal peptide synthetase
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                  • AID65226.1
                  		 35486 - 36460 (-) short chain dehydrogenase
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                    • AID65227.1
                    		 36480 - 37469 (+) LysR family transcriptional regulator
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      Unk01
                      Type
                      nrps-type1
                      Genes
                      ctmA
                      Substrates
                      asparagine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk02
                      Type
                      nrps-type1
                      Genes
                      ctmC
                      Substrates
                      asparagine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk03
                      Type
                      nrps-type1
                      Genes
                      ctmC
                      Substrates
                      phenylalanine, S-beta-hydroxyphenylalanine (evidence: Structure-based inference [1])
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk04
                      Type
                      nrps-type1
                      Genes
                      ctmD
                      Substrates
                      tyrosine (evidence: Structure-based inference [1])
                      Integrated Monomers
                      Domains
                      adenylation
                      Annotation changelog

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Added missing polyketide class
                      • (ID: CUSGWVK3I4TVHJH7NHPFAP2L)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Added NRP substrate specificities
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2019-10-16
                      Updated compound(s) information (NPAtlas curation)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2015-06-12
                      Submitted
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Detailed domain annotation
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