BGC0000336: daptomycin biosynthetic gene cluster from Streptomyces filamentosus NRRL 11379
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Location: 31,568 - 118,209 nt. (total: 86,642 nt).
This entry is originally from NCBI GenBank AY787762.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000336
Short description daptomycin biosynthetic gene cluster from Streptomyces filamentosus NRRL 11379
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AY787762.1
45828 - 108856
via
Compounds
  • daptomycin
Species Streptomyces filamentosus NRRL 11379 [taxonomy]
References
Chemical products information
daptomycin Evidence:
Copy SMILES
C72H101N17O26
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAX31552.1
  • dptP
 45829 - 46449 (-) hypothetical protein
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    • AAX31553.1
    • dptM
    		 47208 - 48167 (+) putative ABC transporter ATP-binding protein
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      • AAX31554.1
      • dptN
      		 48161 - 49030 (+) putative ABC transporter permease
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        • AAX31555.1
        • dptE
        		 49421 - 51214 (+) acyl-CoA ligase
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          • AAX31556.1
          • dptF
          		 51283 - 51552 (+) probable acyl carrier protein
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            • AAX31557.1
            • dptA
            		 51568 - 69060 (+) peptide synthetase 1
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              • AAX31558.1
              • dptBC
              		 69057 - 91073 (+) peptide synthetase 2
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                • AAX31559.1
                • dptD
                		 91070 - 98209 (+) peptide synthetase 3
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                  • AAX31560.1
                  • dptG
                  		 98283 - 98510 (+) putative esterase
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                    • AAX31561.1
                    • dptH
                    		 98548 - 99363 (+) putative hydrolase
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                      • AAX31562.1
                      • dptI
                      		 99447 - 100433 (+) hypothetical protein
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                        • AAX31563.1
                        • dptJ
                        		 100430 - 101167 (+) putative oxidoreductase
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                          • AAX31564.1
                          		 102921 - 103574 (+) probable phosphatase
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                            • AAX31565.1
                            		 103684 - 106551 (-) putative neutral metalloprotease
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                              • AAX31566.1
                              • dptR1
                              		 106688 - 107713 (+) probable regulatory protein
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                                • AAX31567.1
                                • dptR2
                                		 107741 - 108856 (-) probable transcriptional regulator
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                                  Biosynthesis information

                                  Biosynthetic modules

                                  Name
                                  Unk01
                                  Type
                                  nrps-type1
                                  Genes
                                  dptA
                                  Substrates
                                  tryptophan (evidence: Sequence-based prediction, Structure-based inference)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk02
                                  Type
                                  nrps-type1
                                  Genes
                                  dptA
                                  Substrates
                                  asparagine (evidence: Sequence-based prediction, Structure-based inference)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk03
                                  Type
                                  nrps-type1
                                  Genes
                                  dptA
                                  Substrates
                                  aspartic acid (evidence: Sequence-based prediction, Structure-based inference)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk04
                                  Type
                                  nrps-type1
                                  Genes
                                  dptA
                                  Substrates
                                  threonine (evidence: Sequence-based prediction, Structure-based inference)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk05
                                  Type
                                  nrps-type1
                                  Genes
                                  dptA
                                  Substrates
                                  glycine (evidence: Sequence-based prediction, Structure-based inference)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk06
                                  Type
                                  nrps-type1
                                  Genes
                                  dptBC
                                  Substrates
                                  ornithine (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk07
                                  Type
                                  nrps-type1
                                  Genes
                                  dptBC
                                  Substrates
                                  aspartic acid (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk08
                                  Type
                                  nrps-type1
                                  Genes
                                  dptBC
                                  Substrates
                                  alanine (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk09
                                  Type
                                  nrps-type1
                                  Genes
                                  dptBC
                                  Substrates
                                  aspartic acid (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk10
                                  Type
                                  nrps-type1
                                  Genes
                                  dptBC
                                  Substrates
                                  glycine (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk11
                                  Type
                                  nrps-type1
                                  Genes
                                  dptBC
                                  Substrates
                                  serine (evidence: )
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk12
                                  Type
                                  nrps-type1
                                  Genes
                                  dptD
                                  Substrates
                                  3R-methylglutamic acid (evidence: Sequence-based prediction, Structure-based inference)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk13
                                  Type
                                  nrps-type1
                                  Genes
                                  dptD
                                  Substrates
                                  kynurenine (evidence: Sequence-based prediction, Structure-based inference)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Annotation changelog

                                  Entry version: 5

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2024-05-14
                                  MIBiG v4 annotathon
                                  • (ID: 76VHR3W4632SUCCHB24QUXTZ)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 4

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-10-07
                                  Update chemical activity to schema version 2.11
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 3

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Refined reference coordinates
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Updated bioactivity data
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Added NRP substrate specificities
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 2

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2019-10-16
                                  Migrated from v1.4
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2015-06-12
                                  Submitted
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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