BGC0000337: destruxin A biosynthetic gene cluster from Metarhizium robertsii ARSEF 23
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Location: 1 - 106,198 nt. (total: 106,198 nt).
This entry is originally from NCBI GenBank GL698760.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0000337
Short description destruxin A biosynthetic gene cluster from Metarhizium robertsii ARSEF 23
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "The metabolite destruxins are used by the fungus to evade insect host immunities"
Biosynthetic class(es)
  • NRPS (Type I)
Loci
GL698760.1
via Knock-out studies
Compounds
  • destruxin A
Species Metarhizium robertsii ARSEF 23 [taxonomy]
References
Chemical products information
destruxin A Evidence:
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C29H47N5O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • MAA_10031
 1051 - 2514 (+) benzoylformate decarboxylase
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    • MAA_10032
    		 4573 - 6316 (-)
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      • MAA_10033
      		 7766 - 12927 (-)
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        • MAA_10034
        		 14151 - 16040 (+)
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          • MAA_10035
          		 16872 - 18679 (+)
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            • MAA_10036
            		 19976 - 26899 (+)
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              • MAA_10037
              		 27748 - 29731 (+)
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                • MAA_10038
                		 30537 - 32991 (+)
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                  • MAA_10039
                  		 34068 - 35224 (-)
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                    • MAA_10040
                    		 35733 - 36524 (-)
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                      • MAA_10041
                      		 41364 - 43043 (-)
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                        • MAA_10042
                        		 46696 - 47655 (+)
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                          • MAA_10043
                          		 47923 - 71714 (-) non-ribosomal peptide synthetase
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                            • MAA_10044
                            		 72959 - 74873 (-) benzoate 4-monooxygenase cytochrome P450
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                              • MAA_10045
                              		 76321 - 77803 (+) aldo-keto reductase
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                                • MAA_10046
                                		 78302 - 79789 (+) glutamate decarboxylase
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                                  • MAA_10047
                                  		 80445 - 81634 (-)
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                                    • MAA_10048
                                    		 84098 - 88361 (+)
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                                      • MAA_10049
                                      		 95996 - 96244 (+)
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                                        • MAA_10050
                                        		 100674 - 102636 (+)
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                                          • MAA_10051
                                          		 104003 - 104779 (-)
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                                            Biosynthesis information

                                            Biosynthetic modules

                                            Name
                                            Unk01
                                            Type
                                            nrps-type1
                                            Genes
                                            MAA_10043
                                            Substrates
                                            beta-alanine (evidence: Structure-based inference [1])
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk02
                                            Type
                                            nrps-type1
                                            Genes
                                            MAA_10043
                                            Substrates
                                            2-hydroxypent-4-enoic acid, 2-hydroxy-4-methylpentanoic acid, 2,4-dihydroxypentanoic acid, 2,5-dihydroxy-4-methylpentanoic acid, 2-hydroxy-4-methylpentanedioic acid (evidence: Structure-based inference, Mass spectrometry)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk03
                                            Type
                                            nrps-type1
                                            Genes
                                            MAA_10043
                                            Substrates
                                            proline (evidence: Structure-based inference [1])
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk04
                                            Type
                                            nrps-type1
                                            Genes
                                            MAA_10043
                                            Substrates
                                            isoleucine, valine (evidence: Structure-based inference, Mass spectrometry)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk05
                                            Type
                                            nrps-type1
                                            Genes
                                            MAA_10043
                                            Substrates
                                            valine (evidence: Structure-based inference [1])
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk06
                                            Type
                                            nrps-type1
                                            Genes
                                            MAA_10043
                                            Substrates
                                            alanine (evidence: Structure-based inference [1])
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Annotation changelog

                                            Entry version: next

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2024-07-24
                                            MIBiG v4 annotathon
                                            • (ID: C62OJVVH7XOTOTFZSJT727YU)
                                            • (ID: X3QVFXOIMTNXSB4JQGP4RI6A)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 3

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-09-15
                                            Removed duplicate gene annotation
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-09-15
                                            Added NRP substrate specificities
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 2

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2019-10-16
                                            Migrated from v1.4
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2019-10-16
                                            Updated compound(s) information (NPAtlas curation)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 1

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2015-06-12
                                            Submitted
                                            • (ID: XVPU6C2LIDSVZRMGJYGDLQKD)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            Detailed domain annotation
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                                            Modifications to original record
                                            • MAA_10031 was added
                                            • MAA_10032 was added
                                            • MAA_10033 was added
                                            • MAA_10034 was added
                                            • MAA_10035 was added
                                            • MAA_10036 was added
                                            • MAA_10037 was added
                                            • MAA_10038 was added
                                            • MAA_10039 was added
                                            • MAA_10040 was added
                                            • MAA_10041 was added
                                            • MAA_10042 was added
                                            • MAA_10043 was added
                                            • MAA_10044 was added
                                            • MAA_10045 was added
                                            • MAA_10046 was added
                                            • MAA_10047 was added
                                            • MAA_10048 was added
                                            • MAA_10049 was added
                                            • MAA_10050 was added
                                            • MAA_10051 was added