BGC0000372 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000372 (Aspergillus fumigatus Af293)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,indole	1	22,264	hexadehydroastechrome/terezine-D/astechrome	NRPS:Type I	100%

BGC0000372 - Region 1 - NRPS,indole

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Location: 1 - 22,264 nt. (total: 22,264 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
indole: (indsynth or dmat or indole_PTase)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 22,265
Label		BGC0000372

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000372	1.94	NRP	hexadehydroastechrome, terezine-D, astechrome	Aspergillus fumigatus Af293
BGC0000342	0.50	NRP	enniatin	Fusarium equiseti
BGC0002226	0.50	NRP	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872
BGC0002058	0.49	Polyketide, NRP	mutanocyclin	Streptococcus mutans B04Sm5
BGC0002287	0.49	NRP	mutanocyclin, leuvalin, tyrvalin	Streptococcus mutans
BGC0002135	0.47	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002518	0.47	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002437	0.47	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0001261	0.47	NRP	AM-toxin	Alternaria alternata
BGC0001132	0.46	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000372	1.00	NRP	hexadehydroastechrome, terezine-D, astechrome	Aspergillus fumigatus Af293
BGC0002058	0.60	Polyketide, NRP	mutanocyclin	Streptococcus mutans B04Sm5
BGC0002287	0.59	NRP	mutanocyclin, leuvalin, tyrvalin	Streptococcus mutans
BGC0000342	0.58	NRP	enniatin	Fusarium equiseti
BGC0002226	0.58	NRP	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872
BGC0002135	0.57	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002518	0.57	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002437	0.57	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0001261	0.56	NRP	AM-toxin	Alternaria alternata
BGC0001132	0.56	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 22264:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Trp - Ala)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AFUA_3G12920

Search NORINE for peptide: strict or relaxed

AMP-binding (29..419): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVGPFGACTK
Nearest Stachelhaus code(s):: Trp DVGPFGACTK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1086..1465): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DCKMTAGLIK
Nearest Stachelhaus code(s):: Ala DCKMTAGLIK (100% 8Å match)
Stachelhaus code match:: 100% (strong)