BGC0000372: hexadehydroastechrome biosynthetic gene cluster from Aspergillus fumigatus Af293
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Location: 3,423,866 - 3,446,129 nt. (total: 22,264 nt).
This entry is originally from NCBI GenBank CM000171.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000372
Short description hexadehydroastechrome biosynthetic gene cluster from Aspergillus fumigatus Af293
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CM000171.1
3423866 - 3446129
via Knock-out studies, Gene expression correlated with compound production
Compounds
  • hexadehydroastechrome
  • terezine-D
  • astechrome
Species Aspergillus fumigatus Af293 [taxonomy]
References
Chemical products information
hexadehydroastechrome Evidence:
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C60H60Fe1N9O9
terezine-D Evidence:
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C19H23N3O2
Chemical database entries
NPAtlas
astechrome Evidence:
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C60H66Fe1N9O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFUA_3G12890
  • EAL92294.1
 3423866 - 3425153 (-) C6 transcription factor
  • Regulation
  • Knock-out
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  • AFUA_3G12900
  • EAL92293.2
 3426447 - 3427927 (+) MFS transporter, putative
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    • AFUA_3G12910
    • EAL92292.1
    		 3428497 - 3429858 (-) O-methyltransferase
    • Tailoring
    • Knock-out
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    • AFUA_3G12920
    • EAL92291.2
    		 3430194 - 3436923 (+) nonribosomal peptide synthtease
    • Scaffold biosynthesis
    • Knock-out
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    • AFUA_3G12930
    • EAL92290.2
    		 3437617 - 3439088 (+) dimethylallyl tryptophan synthase
    • Tailoring
    • Knock-out
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    • AFUA_3G12940
    • EAL92289.2
    		 3439311 - 3441817 (-) C6 transcription factor
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      • AFUA_3G12950
      • EAL92288.1
      		 3442294 - 3443860 (-) FAD binding domain protein
      • Tailoring
      • Knock-out
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      • AFUA_3G12960
      • EAL92287.1
      		 3444204 - 3446129 (-) cytochrome P450 monooxigenase
      • Tailoring
      • Knock-out
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      Biosynthesis information

      Biosynthetic modules

      Name
      1
      Type
      nrps-type1
      Genes
      AFUA_3G12920
      Substrates
      tryptophan (evidence: Structure-based inference, Knock-out studies)
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      2
      Type
      nrps-type1
      Genes
      AFUA_3G12920
      Substrates
      alanine (evidence: Structure-based inference)
      Integrated Monomers
      Domains
      condensation (Heterocyclization), adenylation
      Annotation changelog

      Entry version: 4

      Date
      Changes
      Submitters
      Reviewers
      2022-10-07
      Update chemical activity to schema version 2.11
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 3

      Date
      Changes
      Submitters
      Reviewers
      2022-09-15
      Corrected NRP module activity
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Updated NRP substrate specificities
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 2

      Date
      Changes
      Submitters
      Reviewers
      2019-10-16
      Migrated from v1.4
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2019-10-16
      Updated compound(s) information (NPAtlas curation)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 1

      Date
      Changes
      Submitters
      Reviewers
      2015-06-12
      Submitted
      • (ID: J4R6BDENZAM7XVDGVEEHZB2Y)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      Detailed domain annotation
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