Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000372.1:
Cluster 1NRP122264

BGC0000372, hexadehydro-astechrome (HAS) biosynthetic gene cluster from Aspergillus fumigatus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: hexadehydroastechrome
SMILES string: Copy to clipboard
Molecular formula: C60H60FeN9O9
Exact molecular mass: 1106.3863 Da ([M+H]+)
Molecular activity: Cytotoxic, Other
Molecular target: iron chelator, coordinates Fe3+

Class-specific details

Biosynthetic class(es):
NRP
Other (cyclic)
Thioesterase type:
None
Release / cyclization type:
Other

Nonribosomal peptide synthetases:
hasD (EAL92291.2)
Module 1
A specificity: Tryptophan
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 2
A specificity: Alanine
Evidence for specificity: Structure-based inference
C domain subtype: Heterocyclization

Gene cluster description

hexadehydro-astechrome (HAS) (BGC0000372). Gene Cluster 1. Biosynthetic class = NRP. GenBank CM000171, positions 3423866-3446129. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?unknown
Evidence for cluster-compound connection:Knock-out studies, Gene expression correlated with compound production, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Philipp Wiemann, Nancy Keller (University of Wisconsin-Madison)

Literature references

1. Wiemann P et al. (2014 TI) Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus. Front Microbiol 5:530. doi: 10.3389/fmicb.2014.00530. eCollection
2. Yin WB et al. (2013) A nonribosomal peptide synthetase-derived iron(III) complex from the pathogenic fungus Aspergillus fumigatus. J Am Chem Soc 135(6):2064-7. doi: 10.1021/ja311145n. Epub 2013 Feb
3. Wang Y et al. (1995) Terezines A-D: new amino acid-derived bioactive metabolites from the coprophilous fungus Sporormiella teretispora. J Nat Prod 58(1):93-9.