BGC0000380: Leupyrrin A1 biosynthetic gene cluster from Sorangium cellulosum
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 80,175 nt. (total: 80,175 nt).
This entry is originally from NCBI GenBank HM639990.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000380
Short description Leupyrrin A1 biosynthetic gene cluster from Sorangium cellulosum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
HM639990.1
via Knock-out studies
Compounds
  • Leupyrrin A1
  • Leupyrrin A2
  • Leupyrrin B1
  • Leupyrrin B2
  • Leupyrrin C
  • Leupyrrin D
Species Sorangium cellulosum [taxonomy]
References
Chemical products information
Leupyrrin A1 Evidence: NMR [1]
Copy SMILES
C41H58N2O10
Chemical database entries
NPAtlas
Leupyrrin A2 Evidence: NMR [1]
Copy SMILES
C41H56N2O10
Chemical database entries
NPAtlas
Leupyrrin B1 Evidence: NMR [1]
Copy SMILES
C41H56N2O10
Chemical database entries
NPAtlas
Leupyrrin B2 Evidence: NMR [1]
Copy SMILES
C41H54N2O10
Chemical database entries
NPAtlas
Leupyrrin C Evidence: NMR [1]
Copy SMILES
C40H56N2O10
Chemical database entries
NPAtlas
Leupyrrin D Evidence: NMR [1]
Copy SMILES
C40H54N2O10
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADZ24981.1
 469 - 2577 (+) hypothetical protein
    copy AA seq
    copy Nt seq
    • ADZ24982.1
    		 3294 - 4130 (+) phospholipid/glycerol acyl transferase
      copy AA seq
      copy Nt seq
      • ADZ24983.1
      		 4221 - 4742 (+) hypothetical protein
        copy AA seq
        copy Nt seq
        • ADZ24984.1
        		 4739 - 6160 (+) protein kinase-like protein
          copy AA seq
          copy Nt seq
          • ADZ24985.1
          • leu1
          		 6346 - 7125 (+) type II thioesterase
            copy AA seq
            copy Nt seq
            • ADZ24986.1
            • leu2
            		 7128 - 9428 (+) formate dehydrogenase
              copy AA seq
              copy Nt seq
              • ADZ24987.1
              • leu3
              		 9476 - 10780 (+) hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyltransferase-like protein
                copy AA seq
                copy Nt seq
                • ADZ24988.1
                • leu4
                		 10927 - 12363 (+) WS/DGAT/MGAT acyltransferase
                  copy AA seq
                  copy Nt seq
                  • ADZ24989.1
                  • leu5
                  		 12385 - 13953 (-) proline adenylation protein
                    copy AA seq
                    copy Nt seq
                    • ADZ24990.1
                    • leu6
                    		 14047 - 15186 (-) prolyl-ACP dehydrogenase
                      copy AA seq
                      copy Nt seq
                      • ADZ24991.1
                      • leu7
                      		 15471 - 15749 (+) acyl carrier protein
                        copy AA seq
                        copy Nt seq
                        • ADZ24992.1
                        • leu8
                        		 15927 - 16688 (-) dehydrogenase
                          copy AA seq
                          copy Nt seq
                          • ADZ24993.1
                          • leu9
                          		 17478 - 19277 (+) C and PCP domain protein
                            copy AA seq
                            copy Nt seq
                            • ADZ24994.1
                            • leu10
                            		 19342 - 20541 (+) carboxylase/reductase
                              copy AA seq
                              copy Nt seq
                              • ADZ24995.1
                              • leuA
                              		 20648 - 29653 (+) non-ribosomal peptide synthase/polyketide synthase
                                copy AA seq
                                copy Nt seq
                                • ADZ24996.1
                                • leuB
                                		 29666 - 36448 (+) polyketide synthase
                                  copy AA seq
                                  copy Nt seq
                                  • ADZ24997.1
                                  • leuC
                                  		 36457 - 42057 (+) polyketide synthase
                                    copy AA seq
                                    copy Nt seq
                                    • ADZ24998.1
                                    • leuD
                                    		 42069 - 48761 (+) polyketide synthase
                                      copy AA seq
                                      copy Nt seq
                                      • ADZ24999.1
                                      • leuE
                                      		 48758 - 53011 (+) non-ribosomal peptide synthase
                                        copy AA seq
                                        copy Nt seq
                                        • ADZ25000.1
                                        • leu11
                                        		 53008 - 54138 (+) phospholipase
                                          copy AA seq
                                          copy Nt seq
                                          • ADZ25001.1
                                          • leu12
                                          		 54135 - 55337 (+) geranyl-geranyl reductase
                                            copy AA seq
                                            copy Nt seq
                                            • ADZ25002.1
                                            • leu13
                                            		 55402 - 56826 (+) Cytochrome P450 enzyme
                                              copy AA seq
                                              copy Nt seq
                                              • ADZ25003.1
                                              • leu14
                                              		 57214 - 58128 (+) O-methyltransferase
                                                copy AA seq
                                                copy Nt seq
                                                • ADZ25004.1
                                                • leu15
                                                		 58157 - 59170 (+) Rieske (2Fe-2S) domain-containing protein
                                                  copy AA seq
                                                  copy Nt seq
                                                  • ADZ25005.1
                                                  • leu16
                                                  		 59322 - 60062 (+) TetR family transcriptional regulator
                                                    copy AA seq
                                                    copy Nt seq
                                                    • ADZ25006.1
                                                    • leu17
                                                    		 60188 - 61993 (-) very-long-chain acyl-CoA synthetase
                                                      copy AA seq
                                                      copy Nt seq
                                                      • ADZ25007.1
                                                      • leu18
                                                      		 62201 - 63649 (+) carotenoid oxygenase
                                                        copy AA seq
                                                        copy Nt seq
                                                        • ADZ25008.1
                                                        • leu19
                                                        		 63733 - 64854 (-) HpcH/HpaI aldolase
                                                          copy AA seq
                                                          copy Nt seq
                                                          • ADZ25009.1
                                                          • leu20
                                                          		 65302 - 66198 (+) HpcH/HpaI aldolase
                                                            copy AA seq
                                                            copy Nt seq
                                                            • ADZ25010.1
                                                            • leu21
                                                            		 66306 - 66833 (+) dehydratase
                                                              copy AA seq
                                                              copy Nt seq
                                                              • ADZ25011.1
                                                              • leu22
                                                              		 66918 - 68366 (-) cytochrome P450 hydroxylase
                                                                copy AA seq
                                                                copy Nt seq
                                                                • ADZ25012.1
                                                                		 69262 - 71409 (-) hypothetical protein
                                                                  copy AA seq
                                                                  copy Nt seq
                                                                  • ADZ25013.1
                                                                  		 71433 - 72665 (-) hypothetical protein
                                                                    copy AA seq
                                                                    copy Nt seq
                                                                    • ADZ25014.1
                                                                    		 72676 - 73602 (-) putative methanol dehydrogenase
                                                                      copy AA seq
                                                                      copy Nt seq
                                                                      • ADZ25015.1
                                                                      		 74219 - 75148 (+) hypothetical protein
                                                                        copy AA seq
                                                                        copy Nt seq
                                                                        Biosynthesis information

                                                                        Biosynthetic modules

                                                                        Name
                                                                        1
                                                                        Type
                                                                        nrps-type1
                                                                        Genes
                                                                        leuA
                                                                        Substrates
                                                                        cysteine (evidence: Structure-based inference [1])
                                                                        Integrated Monomers
                                                                        Domains
                                                                        condensation (Heterocyclization), adenylation
                                                                        Name
                                                                        6
                                                                        Type
                                                                        nrps-type1
                                                                        Genes
                                                                        leuE
                                                                        Substrates
                                                                        proline (evidence: Structure-based inference [1])
                                                                        Integrated Monomers
                                                                        Domains
                                                                        condensation (LCL), adenylation
                                                                        Name
                                                                        2
                                                                        Type
                                                                        pks-modular
                                                                        Genes
                                                                        leuA
                                                                        Substrates
                                                                        Integrated Monomers
                                                                        Domains
                                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                        Name
                                                                        3
                                                                        Type
                                                                        pks-modular
                                                                        Genes
                                                                        leuB
                                                                        Substrates
                                                                        Integrated Monomers
                                                                        Domains
                                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, methyltransferase, carrier (ACP)
                                                                        Name
                                                                        4
                                                                        Type
                                                                        pks-modular
                                                                        Genes
                                                                        leuB
                                                                        Substrates
                                                                        Integrated Monomers
                                                                        Domains
                                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                        Name
                                                                        5
                                                                        Type
                                                                        pks-modular
                                                                        Genes
                                                                        leuD
                                                                        Substrates
                                                                        Integrated Monomers
                                                                        Domains
                                                                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, methyltransferase, carrier (ACP)
                                                                        Annotation changelog

                                                                        Entry version: next

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2024-05-14
                                                                        MIBiG v4 annotathon
                                                                        • (ID: 7ZPV7YL7LI6WACA7MW4GA2DX)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 4

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2022-10-07
                                                                        Update chemical activity to schema version 2.11
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 3

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2022-09-15
                                                                        Corrected NRP module activity
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        2022-09-15
                                                                        Fixed incorrect gene identifiers and names
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        2022-09-15
                                                                        Remove leading/trailing whitespace in gene identifiers
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        2022-09-15
                                                                        Updated NRP substrate specificities
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 2

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2019-10-16
                                                                        Migrated from v1.4
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 1

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2015-06-12
                                                                        Submitted
                                                                        • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        Detailed domain annotation
                                                                        Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                                        A domain glossary is available here, and an explanation of the visualisation is available here.
                                                                        Selected features only
                                                                        Show module domains
                                                                        Similar known gene clusters from MIBiG 4.0
                                                                        Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                                        Click on reference genes to show details of similarities to genes within the current region.
                                                                        Click on an accession to open that entry in the MiBIG database.