BGC0000391 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000391 (Marinactinospora thermotolerans)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,indole	1	14,231	methylpendolmycin/pendolmycin	NRPS:Type I	100%

BGC0000391 - Region 1 - NRPS,indole

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Location: 1 - 14,231 nt. (total: 14,231 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
indole: (indsynth or dmat or indole_PTase)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 14,232
Label		BGC0000391

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000391	1.38	NRP	methylpendolmycin, pendolmycin	Marinactinospora thermotolerans
BGC0002631	0.67	RiPP	myxarylin	Pyxidicoccus fallax
BGC0002084	0.65	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002099	0.65	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0000844	0.52	Other	clavulanic acid	Streptomyces clavuligerus
BGC0002031	0.51	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0001201	0.48	Terpene	eremophilene	Sorangium cellulosum So ce56
BGC0002127	0.46	Polyketide	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0001310	0.45	Polyketide	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0000866	0.45	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000391	1.00	NRP	methylpendolmycin, pendolmycin	Marinactinospora thermotolerans
BGC0002631	0.67	RiPP	myxarylin	Pyxidicoccus fallax
BGC0002084	0.66	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002099	0.66	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002031	0.61	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000384	0.61	NRP	lyngbyatoxin	Lyngbya majuscula
BGC0000313	0.61	NRP	beauvericin	Beauveria bassiana
BGC0002324	0.60	NRP, Polyketide	myxochelin B, myxochelin N, myxochelin O, myxochelin P, myxochelin Q, myxochelin A	Archangium violaceum
BGC0000844	0.59	Other	clavulanic acid	Streptomyces clavuligerus
BGC0000866	0.59	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 14231:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NMe-X - Trp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AFO85453.1

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AMP-binding (422..815): X

nrpys: Ile, Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAYFWGVTFK
Nearest Stachelhaus code(s):: Ile or Val DAYFWGVTFK (100% 8Å match); Val DAYFWGVTFK (85% 8Å match); Ile DAYFWGVTFK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1881..2276): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DGWTISGVCK
Nearest Stachelhaus code(s):: Trp DGWTISGVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)