BGC0000391 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000391 (Marinactinospora thermotolerans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS,indole	1	14,231	High	methylpendolmycin/pendolmycin	NRPS:Type I

BGC0000391 - Region 1 - NRPS,indole

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Location: 1 - 14,231 nt. (total: 14,231 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
indole: (indsynth or dmat or indole_PTase)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 14,232
Label		BGC0000391

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

AFO85454.1: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

AFO85456.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Ligases: ligase

AFO85453.1: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000391.5	1.33	NRPS	methylpendolmycin, pendolmycin	Marinactinospora thermotolerans
BGC0002276.2	0.53	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002084.4	0.48	ribosomal	biarylitide YYH	Planomonospora sp. ID82291
BGC0002099.3	0.48	ribosomal	biarylitide YFH	Planomonospora sp. ID107089
BGC0002631.2	0.43	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0000384.6	0.41	NRPS	lyngbyatoxin	Lyngbya majuscula
BGC0001201.3	0.40	terpene	eremophilene	Sorangium cellulosum So ce56
BGC0001310.5	0.38	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0002127.3	0.34	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0000844.5	0.33	other (other)	clavulanic acid	Streptomyces clavuligerus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000391.5	0.99	NRPS	methylpendolmycin, pendolmycin	Marinactinospora thermotolerans
BGC0000307.4	0.65	NRPS	AbT1	Aureobasidium pullulans
BGC0001135.5	0.64	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002164.2	0.64	NRPS	peramine	Epichloe festucae
BGC0002276.2	0.63	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001641.4	0.63	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.63	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.62	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001166.5	0.62	NRPS	HC-toxin	Alternaria jesenskae

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 14231:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NMe-X - Trp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AFO85453.1: X - Trp

Search NORINE for peptide: strict or relaxed

AMP-binding (422..815): X

nrpys: Ile, Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAYFWGVTFK
Nearest Stachelhaus code(s):: Ile or Val DAYFWGVTFK (100% 8Å match); Val DAYFWGVTFK (85% 8Å match); Ile DAYFWGVTFK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1881..2276): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DGWTISGVCK
Nearest Stachelhaus code(s):: Trp DGWTISGVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor