BGC0000391: methylpendolmycin biosynthetic gene cluster from Marinactinospora thermotolerans
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Location: 1 - 14,231 nt. (total: 14,231 nt).
This entry is originally from NCBI GenBank JN634585.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000391
Short description methylpendolmycin biosynthetic gene cluster from Marinactinospora thermotolerans
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
JN634585.1
via Knock-out studies
Compounds
  • methylpendolmycin
  • pendolmycin
Species Marinactinospora thermotolerans [taxonomy]
References
Chemical products information
methylpendolmycin Evidence:
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C23H33N3O2
pendolmycin Evidence:
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C22H31N3O2
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFO85452.1
 1 - 732 (+) N-acetylglucosaminylphosphatidylinositol deacetylase
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    • AFO85453.1
    		 1146 - 9767 (+) non-ribosomal peptide synthetase
    • Scaffold biosynthesis
    • Knock-out
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    • AFO85454.1
    		 9764 - 11110 (+) P450-like monoxygenase
    • Tailoring
    • Knock-out
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    • AFO85455.1
    		 11167 - 12291 (+) aromatic prenyltransferase
    • Tailoring
    • Knock-out
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    • AFO85456.1
    		 12357 - 13109 (+) reductase/oxidase
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      • AFO85457.1
      		 13133 - 13654 (+) Isopentenyl-diphosphate delta-isomerase
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        • AFO85458.1
        		 13713 - 14231 (+) Acetyltransferase
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          Biosynthesis information

          Biosynthetic modules

          Name
          1
          Type
          nrps-type1
          Genes
          AFO85453.1
          Substrates
          isoleucine, valine (evidence: )
          Integrated Monomers
          Domains
          condensation (LCL), adenylation, methyltransferase
          Name
          2
          Type
          nrps-type1
          Genes
          AFO85453.1
          Substrates
          tryptophan (evidence: Structure-based inference, Knock-out studies)
          Integrated Monomers
          Domains
          adenylation
          Annotation changelog

          Entry version: 4

          Date
          Changes
          Submitters
          Reviewers
          2022-10-07
          Update chemical activity to schema version 2.11
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 3

          Date
          Changes
          Submitters
          Reviewers
          2022-09-15
          Added NRP module
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Updated NRP substrate specificities
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 2

          Date
          Changes
          Submitters
          Reviewers
          2019-10-16
          Migrated from v1.4
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 1

          Date
          Changes
          Submitters
          Reviewers
          2015-06-12
          Submitted
          • (ID: AADADFAEMFE2AOMR24EUYNFH)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          Detailed domain annotation
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