BGC0000395: nocardicin A biosynthetic gene cluster from Nocardia uniformis subsp. tsuyamanensis
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Location: 1 - 33,451 nt. (total: 33,451 nt).
This entry is originally from NCBI GenBank AY541063.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000395
Short description nocardicin A biosynthetic gene cluster from Nocardia uniformis subsp. tsuyamanensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AY541063.1
via
Compounds
  • nocardicin A
Species Nocardia uniformis subsp. tsuyamanensis [taxonomy]
References
Chemical products information
nocardicin A Evidence:
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C23H24N4O9
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAT09795.1
  • nocN
 102 - 1232 (+) NocN
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    • AAT09796.1
    • nocR
    		 1325 - 3073 (+) NocR
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      • AAT09797.1
      • nocL
      		 3103 - 4299 (+) NocL
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        • AAT09798.1
        • nocK
        		 4322 - 5356 (-) NocK
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          • AAT09799.1
          • nocJ
          		 5359 - 6342 (-) NocJ
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            • AAT09800.1
            • nocI
            		 6363 - 6584 (-) NocI
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              • AAT09801.1
              • nocH
              		 6685 - 7911 (+) NocH
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                • AAT09802.1
                • nocG
                		 7945 - 9240 (-) NocG
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                  • AAT09803.1
                  • nocF
                  		 9256 - 10293 (-) NocF
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                    • AAT09804.1
                    • nocA
                    		 10419 - 21497 (+) NocA
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                      • AAT09805.1
                      • nocB
                      		 21494 - 27271 (+) NocB
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                        • AAD46393.1
                        • nat
                        		 27268 - 28173 (+) nocardicin 3-amino-3-carboxypropyl transferase
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                          • AAT09806.1
                          • nocD
                          		 28209 - 28766 (+) NocD
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                            • AAT09807.1
                            • nocE
                            		 29161 - 33405 (+) NocE
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                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              Unk01
                              Type
                              nrps-type1
                              Genes
                              nocA
                              Substrates
                              4-hydroxyphenylglycine (evidence: ATP-PPi exchange assay [2])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk02
                              Type
                              nrps-type1
                              Genes
                              nocA
                              Substrates
                              arginine (evidence: ATP-PPi exchange assay [2])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk03
                              Type
                              nrps-type1
                              Genes
                              nocA
                              Substrates
                              4-hydroxyphenylglycine (evidence: ATP-PPi exchange assay [2])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk04
                              Type
                              nrps-type1
                              Genes
                              nocB
                              Substrates
                              serine (evidence: ATP-PPi exchange assay [2])
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk05
                              Type
                              nrps-type1
                              Genes
                              nocB
                              Substrates
                              4-hydroxyphenylglycine (evidence: ATP-PPi exchange assay [2])
                              Integrated Monomers
                              Domains
                              adenylation
                              Annotation changelog

                              Entry version: 4

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-10-07
                              Update chemical activity to schema version 2.11
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Updated bioactivity data
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Added NRP substrate specificities
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2019-10-16
                              Updated reference publication(s) (MIBiG Annotathon)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2019-10-16
                              Updated compound(s) information (NPAtlas curation)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2015-06-12
                              Submitted
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Detailed domain annotation
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