BGC0000405: δ-(L-α-aminoadipyl)-L-cysteine-D-valine biosynthetic gene cluster from Penicillium chrysogenum
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Location: 1 - 59,497 nt. (total: 59,497 nt).
This entry is originally from NCBI GenBank EF601124.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000405
Short description δ-(L-α-aminoadipyl)-L-cysteine-D-valine biosynthetic gene cluster from Penicillium chrysogenum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
EF601124.1
via Enzymatic assays
Compounds
  • δ-(L-α-aminoadipyl)-L-cysteine-D-valine
  • isopenicillin N
  • benzylpenicillin
  • phenoxymethylpenicillin
Species Penicillium chrysogenum [taxonomy]
References
Chemical products information
δ-(L-α-aminoadipyl)-L-cysteine-D-valine Evidence:
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C14H24N3O6S1
Chemical database entries
ChEBI
isopenicillin N Evidence:
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C14H21N3O6S1
Chemical database entries
ChEBI
benzylpenicillin Evidence:
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C16H17N2Na1O4S1
Chemical database entries
ChEBI
phenoxymethylpenicillin Evidence:
(no structure information available)
C16H18N2O5S1
Chemical database entries
ChEMBL
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABR12607.1
 1 - 1659 (-) isoamyl alcohol oxidase
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    • ABR12608.1
    		 4468 - 5130 (-) hypothetical protein
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      • ABR12609.1
      		 5821 - 7011 (-) hypothetical protein
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        • ABR12610.1
        		 7456 - 8991 (+) hypothetical protein
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          • ABR12611.1
          		 9836 - 12187 (+) hypothetical protein
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            • ABR12612.1
            		 14735 - 15622 (+) hypothetical protein
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              • ABR12613.1
              		 16080 - 17960 (-) hypothetical protein
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                • ABR12614.1
                		 18585 - 20930 (-) hypothetical protein
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                  • ABR12615.1
                  • pcbAB
                  		 25677 - 37052 (-) ACV synthetase
                  • Scaffold biosynthesis
                  • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f568a72bf50>
                  • Activity assay
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                  • ABR12616.1
                  • pcbC
                  		 38068 - 39063 (+) IPN synthase
                  • Tailoring
                  • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f568a765710>
                  • Activity assay
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                  • ABR12617.1
                  • penDE
                  		 40561 - 41835 (+) IPN:acyltransferase
                  • Tailoring
                  • Mutation phenotype: <mibig.converters.shared.mibig.gene.function.MutationPhenotype object at 0x7f568a767fd0>
                  • Activity assay
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                  • ABR12618.1
                  		 42849 - 43628 (-) probable oxidoreductase
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                    • ABR12619.1
                    		 44942 - 46297 (+) hypothetical protein
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                      • ABR12620.1
                      		 49317 - 49781 (+) hypothetical protein
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                        • ABR12621.1
                        		 50291 - 50914 (+) hypothetical protein
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                          • ABR12622.1
                          • erg25
                          		 56117 - 57262 (-) C4-methylsterol oxidase
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                            Biosynthesis information

                            Biosynthetic modules

                            Name
                            0
                            Type
                            nrps-type1
                            Genes
                            pcbAB
                            Substrates
                            2-aminoadipic acid (evidence: ACVS assay [1])
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            1
                            Type
                            nrps-type1
                            Genes
                            pcbAB
                            Substrates
                            cysteine (evidence: ACVS assay [1])
                            Integrated Monomers
                            Domains
                            condensation (DCL), adenylation
                            Name
                            2
                            Type
                            nrps-type1
                            Genes
                            pcbAB
                            Substrates
                            valine (evidence: ACVS assay [1])
                            Integrated Monomers
                            Domains
                            condensation (LCL), adenylation, epimerase
                            Annotation changelog

                            Entry version: 4

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-10-07
                            Update chemical activity to schema version 2.11
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Corrected NRP module activity
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Updated NRP substrate specificities
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2015-06-12
                            Submitted
                            • (ID: 53KWSSAVU3NHQPX32A2FHV6D)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            Detailed domain annotation
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