BGC0000419: ristomycin A biosynthetic gene cluster from Amycolatopsis japonica
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 6,816,619 - 6,885,328 nt. (total: 68,710 nt).
This entry is originally from NCBI GenBank CP008953.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000419
Short description ristomycin A biosynthetic gene cluster from Amycolatopsis japonica
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • saccharide (None)
Loci
CP008953.1
6816619 - 6885328
via Gene expression correlated with compound production
Compounds
  • ristomycin A
Species Amycolatopsis japonica [taxonomy]
References
Chemical products information
ristomycin A Evidence:
Copy SMILES
C95H110N8O44
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AJAP_31985
  • AIG79211.1
  • aroG4
 6816619 - 6817695 (-) 3-deoxy-7-phosphoheptulonate synthase
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • AJAP_31990
  • AIG79212.1
 6817866 - 6818657 (-) Enoyl-CoA Hydratase
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • AJAP_31995
  • AIG79213.1
 6818654 - 6819868 (-) 3,5-Dihydroxyphenylacetyl-CoA oxydase
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • AJAP_32000
  • AIG79214.1
 6819865 - 6820527 (-) Enoyl-CoA Hydratase
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • AJAP_32005
  • AIG79215.1
 6820521 - 6821621 (-) 3,5-Dihydroxyphenylacetyl-CoA synthase
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • AJAP_32010
  • AIG79216.1
 6821820 - 6823547 (-) Mannosyltransferase
  • Tailoring
copy AA seq
copy Nt seq
  • AJAP_32015
  • AIG79217.1
  • staE
 6823709 - 6824326 (-) dTDP-4-keto-6-deoxy-glucose-5-epimerase
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • AJAP_32020
  • AIG79218.1
  • dnrJ
 6824346 - 6825455 (-) C-3 aminotransferase
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • AJAP_32025
  • AIG79219.1
 6825452 - 6826429 (-) NAD-dependent epimerase/dehydratase
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • AJAP_32030
  • AIG79220.1
 6826431 - 6827840 (-) NDP-hexose 2,3-dehydratase
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • AJAP_32035
  • AIG79221.1
 6827846 - 6828916 (-) p-Hydroxymandelate oxidase
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • AJAP_32040
  • AIG79222.1
 6828913 - 6829965 (-) p-Hydroxymandelate synthase
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • AJAP_32045
  • AIG79223.1
 6830076 - 6831266 (-) P450 monooxygenase
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • AJAP_32050
  • AIG79224.1
 6831281 - 6833014 (-) Non-ribosomal peptide synthetase/andenylation domain
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • AJAP_32055
  • AIG79225.1
 6833011 - 6833835 (-) Hydrolase
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • AJAP_32060
  • AIG79226.1
 6833933 - 6835294 (+) Hypothetical protein
    copy AA seq
    copy Nt seq
    • AJAP_32065
    • AIG79227.1
    		 6835631 - 6836671 (-) Methyltransferase
    • Tailoring
    copy AA seq
    copy Nt seq
    • AJAP_32070
    • AIG79228.1
    • tcp
    		 6836735 - 6838552 (-) Mannosyltransferase
    • Tailoring
    copy AA seq
    copy Nt seq
    • AJAP_32075
    • AIG79229.1
    		 6838566 - 6839411 (-) Inactive N-acetylglucosamine deacetylase
      copy AA seq
      copy Nt seq
      • AJAP_32080
      • AIG79230.1
      		 6839408 - 6840532 (-) UDP-N-acetylglucosamine transferase
      • Tailoring
      copy AA seq
      copy Nt seq
      • AJAP_32085
      • AIG79231.1
      		 6840552 - 6841364 (-) Methyltransferase
      • Tailoring
      copy AA seq
      copy Nt seq
      • AJAP_32090
      • AIG79232.1
      		 6841390 - 6842604 (-) UDP-N-acetylglucosamine transferase
      • Tailoring
      copy AA seq
      copy Nt seq
      • AJAP_32095
      • AIG79233.1
      		 6842620 - 6843837 (-) UDP-N-acetylglucosamine transferase
      • Tailoring
      copy AA seq
      copy Nt seq
      • AJAP_32100
      • AIG79234.1
      		 6843859 - 6845016 (-) UDP-N-acetylglucosamine transferase
      • Tailoring
      copy AA seq
      copy Nt seq
      • AJAP_32105
      • AIG79235.1
      		 6845029 - 6846270 (-) P450 monooxygenase
      • Scaffold biosynthesis
      copy AA seq
      copy Nt seq
      • AJAP_32110
      • AIG79236.1
      		 6846387 - 6847583 (-) P450 monooxygenase
      • Scaffold biosynthesis
      copy AA seq
      copy Nt seq
      • AJAP_32115
      • AIG79237.1
      		 6847573 - 6848730 (-) P450 monooxygenase
      • Scaffold biosynthesis
      copy AA seq
      copy Nt seq
      • AJAP_32120
      • AIG79238.1
      		 6848753 - 6849928 (-) P450 monooxygenase
      • Scaffold biosynthesis
      copy AA seq
      copy Nt seq
      • AJAP_32125
      • AIG79239.1
      		 6850158 - 6850367 (-) Hypothetical protein
        copy AA seq
        copy Nt seq
        • AJAP_32130
        • AIG79240.1
        		 6850379 - 6855940 (-) Hypothetical protein
          copy AA seq
          copy Nt seq
          • AJAP_32135
          • AIG79241.1
          		 6856097 - 6868081 (-) Hypothetical protein
            copy AA seq
            copy Nt seq
            • AJAP_32140
            • AIG79242.1
            		 6868406 - 6871558 (-) Non-ribosomal peptide synthetase
            • Scaffold biosynthesis
            copy AA seq
            copy Nt seq
            • AJAP_32145
            • AIG79243.1
            		 6871555 - 6877743 (-) Non-ribosomal peptide synthetase
            • Scaffold biosynthesis
            copy AA seq
            copy Nt seq
            • AJAP_32150
            • AIG79244.1
            		 6877746 - 6879698 (-) Conserved putative membrane protein
              copy AA seq
              copy Nt seq
              • AJAP_32155
              • AIG79245.1
              		 6879880 - 6880710 (-) Prephenate dehydrogenase
              • Precursor biosynthesis
              copy AA seq
              copy Nt seq
              • AJAP_32160
              • AIG79246.1
              		 6880848 - 6881645 (-) StrR-like regulator
              • Regulation
              copy AA seq
              copy Nt seq
              • AJAP_32165
              • AIG79247.1
              • vanX
              		 6882786 - 6883394 (-) D-Ala-D-Ala dipeptidase
              • Resistance/immunity
              copy AA seq
              copy Nt seq
              • AJAP_32170
              • AIG79248.1
              		 6883384 - 6884430 (-) D-Ala-D-Lac ligase
              • Resistance/immunity
              copy AA seq
              copy Nt seq
              • AJAP_32175
              • AIG79249.1
              • vanH
              		 6884432 - 6885328 (-) D-Lactate dehydrogenase
              • Resistance/immunity
              copy AA seq
              copy Nt seq
              Biosynthesis information

              Biosynthetic modules

              Name
              1
              Type
              nrps-type1
              Genes
              AJAP_32145
              Substrates
              4-hydroxyphenylglycine (evidence: Structure-based inference)
              Integrated Monomers
              Domains
              condensation, adenylation
              Name
              2
              Type
              nrps-type1
              Genes
              AJAP_32145 AJAP_32140
              Substrates
              R-beta-hydroxytyrosine (evidence: Structure-based inference)
              Integrated Monomers
              Domains
              adenylation, epimerase
              Name
              3
              Type
              nrps-type1
              Genes
              AJAP_32140 AJAP_32135
              Substrates
              3,5-dihydroxyphenylglycine (evidence: Structure-based inference)
              Integrated Monomers
              Domains
              adenylation
              Name
              4
              Type
              nrps-type1
              Genes
              AJAP_32135
              Substrates
              4-hydroxyphenylglycine (evidence: Structure-based inference)
              Integrated Monomers
              Domains
              condensation, adenylation, epimerase
              Name
              5
              Type
              nrps-type1
              Genes
              AJAP_32135
              Substrates
              4-hydroxyphenylglycine (evidence: Structure-based inference)
              Integrated Monomers
              Domains
              condensation, adenylation, epimerase
              Name
              6
              Type
              nrps-type1
              Genes
              AJAP_32135 AJAP_32130
              Substrates
              R-beta-hydroxytyrosine (evidence: Structure-based inference)
              Integrated Monomers
              Domains
              adenylation
              Name
              7
              Type
              nrps-type1
              Genes
              AJAP_32130
              Substrates
              3,5-dihydroxyphenylglycine (evidence: Structure-based inference)
              Integrated Monomers
              Domains
              condensation, adenylation
              Annotation changelog

              Entry version: 4

              Date
              Changes
              Submitters
              Reviewers
              2022-10-07
              Update chemical activity to schema version 2.11
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 3

              Date
              Changes
              Submitters
              Reviewers
              2022-09-15
              Corrected NRP module activity
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Removed saccharide information of BGC0000805
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Updated NRP substrate specificities
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 2

              Date
              Changes
              Submitters
              Reviewers
              2019-10-16
              Migrated from v1.4
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 1

              Date
              Changes
              Submitters
              Reviewers
              2015-06-12
              Submitted
              • (ID: TVYWRCMOBR5VOOLSE2IIZG7H)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Detailed domain annotation
              Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
              A domain glossary is available here, and an explanation of the visualisation is available here.
              Selected features only
              Show module domains
              Similar known gene clusters from MIBiG 4.0
              Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
              Click on reference genes to show details of similarities to genes within the current region.
              Click on an accession to open that entry in the MiBIG database.