BGC0000419: ristomycin A biosynthetic gene cluster from Amycolatopsis japonica
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Location: 6,816,619 - 6,885,328 nt. (total: 68,710 nt).
This entry is originally from NCBI GenBank CP008953.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000419
Short description ristomycin A biosynthetic gene cluster from Amycolatopsis japonica
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Glycopeptide)
  • Saccharide
Loci NCBI GenBank: CP008953.1
Compounds
  • ristomycin A
Species Amycolatopsis japonica [taxonomy]
References
Chemical products information
ristomycin A [synonyms: Ristocetin a]
Copy SMILES
C95H110N8O44
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AJAP_31985
  • AIG79211.1
  • aroG4
 6816619 - 6817695 (-) 3-deoxy-7-phosphoheptulonate synthase
  • Precursor biosynthesis
Sequence-based prediction
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  • AJAP_31990
  • AIG79212.1
 6817866 - 6818657 (-) Enoyl-CoA Hydratase
  • Precursor biosynthesis
Sequence-based prediction
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  • AJAP_31995
  • AIG79213.1
 6818654 - 6819868 (-) 3,5-Dihydroxyphenylacetyl-CoA oxydase
  • Precursor biosynthesis
Sequence-based prediction
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  • AJAP_32000
  • AIG79214.1
 6819865 - 6820527 (-) Enoyl-CoA Hydratase
  • Precursor biosynthesis
Sequence-based prediction
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  • AJAP_32005
  • AIG79215.1
 6820521 - 6821621 (-) 3,5-Dihydroxyphenylacetyl-CoA synthase
  • Precursor biosynthesis
Sequence-based prediction
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  • AJAP_32010
  • AIG79216.1
 6821820 - 6823547 (-) Mannosyltransferase
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • AJAP_32015
  • AIG79217.1
  • staE
 6823709 - 6824326 (-) dTDP-4-keto-6-deoxy-glucose-5-epimerase
  • Precursor biosynthesis
Sequence-based prediction
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  • AJAP_32020
  • AIG79218.1
  • dnrJ
 6824346 - 6825455 (-) C-3 aminotransferase
  • Precursor biosynthesis
Sequence-based prediction
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  • AJAP_32025
  • AIG79219.1
 6825452 - 6826429 (-) NAD-dependent epimerase/dehydratase
  • Precursor biosynthesis
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  • AJAP_32030
  • AIG79220.1
 6826431 - 6827840 (-) NDP-hexose 2,3-dehydratase
  • Precursor biosynthesis
Sequence-based prediction
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  • AJAP_32035
  • AIG79221.1
 6827846 - 6828916 (-) p-Hydroxymandelate oxidase
  • Precursor biosynthesis
Sequence-based prediction
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  • AJAP_32040
  • AIG79222.1
 6828913 - 6829965 (-) p-Hydroxymandelate synthase
  • Precursor biosynthesis
Sequence-based prediction
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  • AJAP_32045
  • AIG79223.1
 6830076 - 6831266 (-) P450 monooxygenase
  • Precursor biosynthesis
Sequence-based prediction
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  • AJAP_32050
  • AIG79224.1
 6831281 - 6833014 (-) Non-ribosomal peptide synthetase/andenylation domain
  • Precursor biosynthesis
Sequence-based prediction
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  • AJAP_32055
  • AIG79225.1
 6833011 - 6833835 (-) Hydrolase
  • Precursor biosynthesis
Sequence-based prediction
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  • AJAP_32060
  • AIG79226.1
 6833933 - 6835294 (+) Hypothetical protein
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  • AJAP_32065
  • AIG79227.1
 6835631 - 6836671 (-) Methyltransferase
  • Tailoring (Methylation)
Sequence-based prediction
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  • AJAP_32070
  • AIG79228.1
  • tcp
 6836735 - 6838552 (-) Mannosyltransferase
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • AJAP_32075
  • AIG79229.1
 6838566 - 6839411 (-) Inactive N-acetylglucosamine deacetylase
  • Unknown
Sequence-based prediction
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  • AJAP_32080
  • AIG79230.1
 6839408 - 6840532 (-) UDP-N-acetylglucosamine transferase
  • Tailoring (Glycosylation)
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  • AJAP_32085
  • AIG79231.1
 6840552 - 6841364 (-) Methyltransferase
  • Tailoring (Methylation)
Sequence-based prediction
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  • AJAP_32090
  • AIG79232.1
 6841390 - 6842604 (-) UDP-N-acetylglucosamine transferase
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • AJAP_32095
  • AIG79233.1
 6842620 - 6843837 (-) UDP-N-acetylglucosamine transferase
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • AJAP_32100
  • AIG79234.1
 6843859 - 6845016 (-) UDP-N-acetylglucosamine transferase
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • AJAP_32105
  • AIG79235.1
 6845029 - 6846270 (-) P450 monooxygenase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AJAP_32110
  • AIG79236.1
 6846387 - 6847583 (-) P450 monooxygenase
  • Scaffold biosynthesis
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  • AJAP_32115
  • AIG79237.1
 6847573 - 6848730 (-) P450 monooxygenase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AJAP_32120
  • AIG79238.1
 6848753 - 6849928 (-) P450 monooxygenase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AJAP_32125
  • AIG79239.1
 6850158 - 6850367 (-) Hypothetical protein
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  • AJAP_32130
  • AIG79240.1
 6850379 - 6855940 (-) Hypothetical protein
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  • AJAP_32135
  • AIG79241.1
 6856097 - 6868081 (-) Hypothetical protein
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  • AJAP_32140
  • AIG79242.1
 6868406 - 6871558 (-) Non-ribosomal peptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AJAP_32145
  • AIG79243.1
 6871555 - 6877743 (-) Non-ribosomal peptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AJAP_32150
  • AIG79244.1
 6877746 - 6879698 (-) Conserved putative membrane protein
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  • AJAP_32155
  • AIG79245.1
 6879880 - 6880710 (-) Prephenate dehydrogenase
  • Precursor biosynthesis
Sequence-based prediction
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  • AJAP_32160
  • AIG79246.1
 6880848 - 6881645 (-) StrR-like regulator
  • Regulation
Sequence-based prediction
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  • AJAP_32165
  • AIG79247.1
  • vanX
 6882786 - 6883394 (-) D-Ala-D-Ala dipeptidase
  • Resistance/immunity
Sequence-based prediction
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  • AJAP_32170
  • AIG79248.1
 6883384 - 6884430 (-) D-Ala-D-Lac ligase
  • Resistance/immunity
Sequence-based prediction
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  • AJAP_32175
  • AIG79249.1
  • vanH
 6884432 - 6885328 (-) D-Lactate dehydrogenase
  • Resistance/immunity
Sequence-based prediction
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NRP-specific information
Subclass Glycopeptide
Cyclic? no
Thioesterase genes
  • AJAP_32130 (Unknown)
NRP-synthases
Gene Modules
AJAP_32145
Module 1
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Module 2
Specificity: R-beta-hydroxytyrosine
Evidence for specificity:
  • Structure-based inference
AJAP_32140
Module 2
Condensation domain type: Unknown
Module 3
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
AJAP_32135
Module 3
Condensation domain type: Unknown
Module 4
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Module 5
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Module 6
Specificity: R-beta-hydroxytyrosine
Evidence for specificity:
  • Structure-based inference
AJAP_32130
Module 6
Condensation domain type: Unknown
Module 7
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: TVYWRCMOBR5VOOLSE2IIZG7H, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed saccharide information of BGC0000805
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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