BGC0000420: histidyltryptophanyldiketopiperazine biosynthetic gene cluster from Penicillium rubens Wisconsin 54-1255
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Location: 3,638,081 - 3,658,739 nt. (total: 20,659 nt).
This entry is originally from NCBI GenBank AM920436.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000420
Short description histidyltryptophanyldiketopiperazine biosynthetic gene cluster from Penicillium rubens Wisconsin 54-1255
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AM920436.1
3638081 - 3658739
via Knock-out studies
Compounds
  • histidyltryptophanyldiketopiperazine
  • dehydrohistidyltryptophanyldiketopiperazine
  • roquefortine D
  • roquefortine C
  • glandicoline A
  • glandicoline B
  • meleagrine
Species Penicillium rubens Wisconsin 54-1255 [taxonomy]
References
Chemical products information
histidyltryptophanyldiketopiperazine [synonyms: htd] Evidence: NMR [1]
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C17H17N5O2
dehydrohistidyltryptophanyldiketopiperazine [synonyms: dhtd] Evidence: NMR [3]
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C17H15N5O2
Chemical database entries
ChEBI
roquefortine D Evidence: NMR [3]
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C22H25N5O2
Chemical database entries
NPAtlas
roquefortine C [synonyms: Isoroquefortine C, Roquefortine] Evidence: NMR [2]
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C22H23N5O2
Chemical database entries
PubCHEM
NPAtlas
glandicoline A Evidence: MS/MS [5]
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C22H21N5O3
Chemical database entries
PubCHEM
glandicoline B Evidence: NMR [3]
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C22H21N5O4
Chemical database entries
PubCHEM
meleagrine Evidence: NMR [4]
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C23H23N5O4
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PCH_Pc21g15420
  • CAP96439.1
  • Pc21g15420
 3638081 - 3639872 (+) Transporter
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    • PCH_Pc21g15430
    • CAP96440.1
    • Pc21g15430
    		 3640720 - 3642058 (+) dimethylallyltryptophan synthase
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      • PCH_Pc21g15440
      • CAP96441.1
      • Pc21g15440
      		 3642415 - 3643447 (-) methyltransferase
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        • PCH_Pc21g15450
        • CAP96442.1
        • Pc21g15450
        		 3644030 - 3645882 (+) P450 monooxygenase
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          • PCH_Pc21g15460
          • CAP96443.1
          • Pc21g15460
          		 3646230 - 3647739 (-) MAK1-type monooxygenase
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            • PCH_Pc21g15470
            • CAP96444.1
            • Pc21g15470
            		 3649100 - 3650745 (-) cytochrome P450 oxidoreductase
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              • PCH_Pc21g15480
              • CAP96445.1
              • Pc21g15480
              		 3651282 - 3658739 (+) NRPS
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                Biosynthesis information

                Biosynthetic modules

                Name
                0
                Type
                nrps-type1
                Genes
                Pc21g15480
                Substrates
                tryptophan (evidence: Structure-based inference, Homology)
                Integrated Monomers
                Domains
                adenylation
                Name
                1
                Type
                nrps-type1
                Genes
                Pc21g15480
                Substrates
                histidine (evidence: Structure-based inference, Homology)
                Integrated Monomers
                Domains
                condensation (DCL), adenylation
                Annotation changelog

                Entry version: next

                Date
                Changes
                Submitters
                Reviewers
                2024-04-23
                MIBiG v4 annotathon
                • (ID: WGYEEFADVXA7X4KRF2R4CDK4)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 4

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Cleaned up synonym list
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Corrected NRP module activity
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Updated NRP substrate specificities
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2019-10-16
                Updated compound(s) information (MIBiG Annotathon)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2019-10-16
                Updated compound(s) information (NPAtlas curation)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2015-06-12
                Submitted
                • (ID: 53KWSSAVU3NHQPX32A2FHV6D)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Detailed domain annotation
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