Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000424.1:
Cluster 1NRP142152

BGC0000424, serobactins biosynthetic gene cluster from Herbaspirillum seropedicae. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Serobactin C
SMILES string: Copy to clipboard
Molecular formula: C37H63N7O17
Exact molecular mass: 900.41 Da (M+Na+)
Molecular activity: Siderophore

Class-specific details

Biosynthetic class(es):
NRP
NRP siderophore (linear)
Thioesterase type:
Type I & II
Release / cyclization type:
Hydrolysis

Nonribosomal peptide synthetases:
Hsero_2343
Module 0
A specificity: C10:0; C12:0; C14:0
Evidence for specificity: Structure-based inference
C domain subtype: Other
Module 1
A specificity: Aspartate
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: LCL
Module 2
A specificity: Serine
Evidence for specificity: Structure-based inference
C domain subtype: DCL
Module 3
A specificity: Aspartate
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Scaffold-modifying domain: Hydroxylation
Module 4
A specificity: Threonine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: LCL
Module 5
A specificity: Serine
Evidence for specificity: Structure-based inference
C domain subtype: DCL
Module 6
A specificity: N5-Hydroxyornithine
Evidence for specificity: Structure-based inference
Amino acid biosynthesis subcluster: hsero_2346
C domain subtype: DCL

Gene cluster description

serobactins (BGC0000424). Gene Cluster 1. Biosynthetic class = NRP. GenBank CP002039, positions 2645251-2687402. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Proven expression in natural host, Sequence-based prediction, Other
MIxS-compliance:Unknown
Contact for this cluster:Federico Rosconi (Instituto de Investigaciones Biologicas Clemente Estabel)

Literature references

1. Rosconi F et al. (2013) Identification and structural characterization of serobactins, a suite of lipopeptide siderophores produced by the grass endophyte Herbaspirillum seropedicae. Environ Microbiol 15(3):916-27. doi: 10.1111/1462-2920.12075. Epub 2013