BGC0000432: streptothricin F biosynthetic gene cluster from Streptomyces rochei NBRC 12908
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Location: 1 - 34,051 nt. (total: 34,051 nt).
This entry is originally from NCBI GenBank AB684619.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000432
Short description streptothricin F biosynthetic gene cluster from Streptomyces rochei NBRC 12908
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AB684619.1
1 - 34051
via Heterologous expression
Compounds
  • streptothricin F
  • streptothricin E
  • streptothricin D
  • streptothricin C
Species Streptomyces rochei NBRC 12908 [taxonomy]
References
Chemical products information
streptothricin F [synonyms: nourseothricin F, racemomycin F, yazumycin F] Evidence:
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streptothricin E [synonyms: nourseothricin E, yazumycin E, racemomycin E] Evidence:
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streptothricin D [synonyms: nourseothricin D, yazumycin D, racemomycin D] Evidence:
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streptothricin C [synonyms: yazumycin C, nourseothricin C, racemomycin C] Evidence:
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List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAL15714.1
 1564 - 2133 (+) streptothricin acetyltransferase
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    • BAL15715.1
    		 2109 - 2888 (-) hypothetical protein
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      • BAL15716.1
      		 2878 - 3708 (-) hydrolase
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        • BAL15717.1
        		 3705 - 4811 (-) macrolide phosphotransferase
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          • BAL15718.1
          		 4808 - 6325 (-) NRPS
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            • BAL15719.1
            		 6327 - 8075 (+) peptidase
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              • BAL15720.1
              		 8040 - 9119 (-) glycosyl transferase
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                • BAL15721.1
                		 9332 - 10564 (-) carbamoyl-phosphate synthetase
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                  • BAL15722.1
                  		 10557 - 11261 (-) hypothetical protein
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                    • BAL15723.1
                    		 11258 - 13288 (-) oxidoreductase
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                      • BAL15724.1
                      		 13380 - 14123 (-) acyltransferase
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                        • BAL15725.1
                        		 14132 - 15166 (-) L-arginine beta-hydroxylase
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                          • BAL15726.1
                          		 15476 - 17464 (-) NRPS
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                            • BAL15727.1
                            		 17461 - 18621 (-) aminotransferase
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                              • BAL15728.1
                              		 18641 - 20065 (-) L-lysine 2,3-aminotransferase
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                                • BAL15729.1
                                		 20460 - 21437 (+) regulatory protein
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                                  • BAL15730.1
                                  		 21508 - 23241 (+) carbamoyl transferase
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                                    • BAL15731.1
                                    		 23238 - 25061 (+) NRPS
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                                      • BAL15732.1
                                      		 25099 - 26778 (+) NRPS
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                                        • BAL15733.1
                                        		 26775 - 28469 (+) ABC transporter
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                                          • BAL15734.1
                                          		 28466 - 30400 (+) ABC transporter
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                                            • BAL15735.1
                                            		 30504 - 31232 (+) Tyr/Ser phosphatase
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                                              • BAL15736.1
                                              		 31495 - 31908 (+) transposase
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                                                • BAL15737.1
                                                		 32522 - 32878 (+) transposase
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                                                  Biosynthesis information

                                                  Biosynthetic modules

                                                  Name
                                                  Unk01
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  BAL15718.1
                                                  Substrates
                                                  beta-lysine (evidence: ATP-PPi exchange assay, Structure-based inference, Sequence-based prediction)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk02
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  BAL15732.1
                                                  Substrates
                                                  beta-lysine (evidence: ATP-PPi exchange assay, Structure-based inference, Sequence-based prediction)
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Annotation changelog

                                                  Entry version: next

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2024-06-13
                                                  MIBiG v4 annotathon
                                                  • (ID: FBXTIUNG3HRTIEDBCVCE5GME)
                                                  • (ID: RKFOW2BJ2UIGZ6GYHFZX4BHF)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: next

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2023-10-06
                                                  Specified congeners F, E, D, and C of streptothricin, as reported in reference https://doi.org/10.1038/nchembio.1040 Also added coordinates and evidence
                                                  • (ID: RKFOW2BJ2UIGZ6GYHFZX4BHF)
                                                  • (ID: C62OJVVH7XOTOTFZSJT727YU)
                                                  • (ID: 6Q7UQYZ273A5REKZFDZCLJJ7)
                                                  2023-10-13
                                                  Added synonyms and activities to all 4 metabolites (ST-F, E, D, C)
                                                  • (ID: RKFOW2BJ2UIGZ6GYHFZX4BHF)
                                                  • (ID: C62OJVVH7XOTOTFZSJT727YU)
                                                  • (ID: 6Q7UQYZ273A5REKZFDZCLJJ7)
                                                  2023-10-17
                                                  Fix compound evidence
                                                  • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
                                                  • (ID: C62OJVVH7XOTOTFZSJT727YU)
                                                  • (ID: 6Q7UQYZ273A5REKZFDZCLJJ7)

                                                  Entry version: 4

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-10-07
                                                  Update chemical activity to schema version 2.11
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 3

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-09-15
                                                  Updated bioactivity data
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-09-15
                                                  Added NRP substrate specificities
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 2

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2019-10-16
                                                  Migrated from v1.4
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 1

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2015-06-12
                                                  Submitted
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  Detailed domain annotation
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