BGC0000434: SW-163C biosynthetic gene cluster from Streptomyces sp. SNA15896
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Location: 1 - 55,697 nt. (total: 55,697 nt).
This entry is originally from NCBI GenBank AB375771.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000434
Short description SW-163C biosynthetic gene cluster from Streptomyces sp. SNA15896
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AB375771.1
via
Compounds
  • SW-163C
  • UK-63598
  • SW-163E
  • SW-163F
  • SW-163G
Species Streptomyces sp. SNA15896 [taxonomy]
References
Chemical products information
SW-163C Evidence:
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C52H60N10O14S2
Chemical database entries
NPAtlas
PubCHEM
UK-63598 Evidence:
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C53H62N10O14S2
Chemical database entries
NPAtlas
SW-163E Evidence:
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C54H64N10O14S2
Chemical database entries
NPAtlas
PubCHEM
SW-163F Evidence:
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C55H66N10O14S2
Chemical database entries
NPAtlas
SW-163G Evidence:
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C56H68N10O14S2
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAI63266.1
 165 - 2399 (+) putative oxidoreductase
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    • BAI63267.1
    		 3228 - 6521 (-) hypothetical protein
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      • BAI63268.1
      		 8593 - 8793 (+) putative integral membrane protein
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        • BAI63269.1
        		 8921 - 9919 (-) putative 2-nitropropane dioxygenase
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          • BAI63270.1
          		 10431 - 11810 (-) hypothetical protein
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            • BAI63271.1
            		 12010 - 12426 (-) hypothetical protein
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              • BAI63272.1
              		 13117 - 14178 (+) hypothetical protein
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                • BAI63273.1
                • swb1
                		 14832 - 16079 (-) putative kynurenine aminotransferase
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                  • BAI63274.1
                  • swb2
                  		 16199 - 16954 (-) putative oxidoreductase
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                    • BAI63275.1
                    • swb3
                    		 17013 - 17795 (-) putative transcription regulator
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                      • BAI63276.1
                      • swb4
                      		 17971 - 18960 (+) putative ABC transporter
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                        • BAI63277.1
                        • swb5
                        		 18951 - 19781 (+) putative ABC transporter
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                          • BAI63278.1
                          • swb6
                          		 19824 - 20993 (-) putative aminotransferase
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                            • BAI63279.1
                            • swb7
                            		 20990 - 22426 (-) hypothetical protein
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                              • BAI63280.1
                              • swb8
                              		 23253 - 23939 (+) putative SAM-dependent methyltransferase
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                                • BAI63281.1
                                • swb9
                                		 23981 - 26020 (+) putative Mg-protoporphyrin IX monooxidative cyclase
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                                  • BAI63282.1
                                  • swb10
                                  		 26066 - 26761 (+) putative tryptophan 2,3-dioxygenase
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                                    • BAI63283.1
                                    • swb11
                                    		 26823 - 28571 (-) putative non-ribosomal peptide synthetase
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                                      • BAI63284.1
                                      • swb12
                                      		 28689 - 30275 (-) putative peptide arylation enzyme
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                                        • BAI63285.1
                                        • swb13
                                        		 30122 - 31492 (-) putative cytochrome P450
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                                          • BAI63286.1
                                          • swb14
                                          		 31651 - 32397 (+) putative thioesterase
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                                            • BAI63287.1
                                            • swb15
                                            		 32468 - 34846 (-) UvrA-like protein
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                                              • BAI63288.1
                                              • swb16
                                              		 35089 - 42852 (+) putative non-ribosomal peptide synthetase
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                                                • BAI63289.1
                                                • swb17
                                                		 42861 - 52334 (+) putative non-ribosomal peptide synthetase
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                                                  • BAI63290.1
                                                  • swb18
                                                  		 52369 - 52581 (+) MbtH-like protein
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                                                    • BAI63291.1
                                                    • swb19
                                                    		 52668 - 53180 (+) putative OmpR-family regulator
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                                                      • BAI63292.1
                                                      • swb20
                                                      		 53285 - 54223 (-) putative oxidoreductase
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                                                        • BAI63293.1
                                                        		 54264 - 55697 (-) hypothetical protein
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                                                          Biosynthesis information

                                                          Biosynthetic modules

                                                          Name
                                                          Unk01
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          swb11
                                                          Substrates
                                                          tryptophan (evidence: Structure-based inference, Homology, Heterologous expression)
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Name
                                                          Unk02
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          swb12
                                                          Substrates
                                                          3-hydroxyquinaldic acid (evidence: Structure-based inference, Homology, Heterologous expression)
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Name
                                                          Unk03
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          swb16
                                                          Substrates
                                                          serine (evidence: Structure-based inference, Homology, Heterologous expression)
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Name
                                                          Unk04
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          swb16
                                                          Substrates
                                                          alanine (evidence: Structure-based inference, Homology, Heterologous expression)
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Name
                                                          Unk05
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          swb17
                                                          Substrates
                                                          cysteine (evidence: Structure-based inference, Homology, Heterologous expression)
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Name
                                                          Unk06
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          swb17
                                                          Substrates
                                                          norcoronamic acid (evidence: Structure-based inference, Homology, Heterologous expression)
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Annotation changelog

                                                          Entry version: 4

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-10-07
                                                          Update chemical activity to schema version 2.11
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 3

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-09-15
                                                          Updated bioactivity data
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-09-15
                                                          Added NRP substrate specificities
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 2

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2019-10-16
                                                          Migrated from v1.4
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2019-10-16
                                                          Updated compound(s) information (MIBiG Annotathon)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2019-10-16
                                                          Updated compound(s) information (NPAtlas curation)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 1

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2015-06-12
                                                          Submitted
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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