BGC0000434 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000434 (Streptomyces sp. SNA15896)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like,NRPS	1	55,697	thiocoraline	NRP:Cyclic depsipeptide	42%

BGC0000434 - Region 1 - NRPS,NRPS-like

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Location: 1 - 55,697 nt. (total: 55,697 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 55,698
Label		BGC0000434

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000434.1	1.25	NRP	SW-163C, UK-63598, SW-163E, SW-163F, SW-163G	Streptomyces sp. SNA15896
BGC0001561.1	0.68	NRP	curacomycin	Streptomyces curacoi
BGC0000375.1	0.68	NRP	indigoidine	Streptomyces chromofuscus
BGC0000457.1	0.66	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000427.1	0.65	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000900.1	0.64	Other	ferrichrome	Aspergillus oryzae
BGC0001249.1	0.64	NRP	dimethylcoprogen	Alternaria alternata
BGC0000348.1	0.64	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001718.1	0.60	NRP	okaramine D	Aspergillus aculeatus ATCC 16872
BGC0001444.1	0.59	Other	caboxamycin	Streptomyces sp. NTK 937

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000434.1	0.89	NRP	SW-163C, UK-63598, SW-163E, SW-163F, SW-163G	Streptomyces sp. SNA15896
BGC0001561.1	0.67	NRP	curacomycin	Streptomyces curacoi
BGC0000375.1	0.67	NRP	indigoidine	Streptomyces chromofuscus
BGC0000457.1	0.66	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000427.1	0.66	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000900.1	0.65	Other	ferrichrome	Aspergillus oryzae
BGC0001249.1	0.65	NRP	dimethylcoprogen	Alternaria alternata
BGC0000348.1	0.65	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001735.1	0.64	Other	pentostatine, vidarabine	Streptomyces antibioticus
BGC0001718.1	0.64	NRP	okaramine D	Aspergillus aculeatus ATCC 16872

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 8592 - 55697:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (D-ser - gly) + (NMe-cys - NMe-val)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 8592 - 42852:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (D-ser - gly)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 15088 - 55697:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (D-ser - gly) + (NMe-cys - NMe-val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

swb11

Search NORINE for peptide: strict or relaxed

AMP-binding (8..406): X

NRPSPredictor2: phe, trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: phe, trp
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWTVtgVgK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 70% (weak)

swb12

Search NORINE for peptide: strict or relaxed

AMP-binding (32..429): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: dhb, sal
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: aLPtQGwLtK
Nearest Stachelhaus code:: sal
Stachelhaus code match:: 60% (weak)

swb16

Search NORINE for peptide: strict or relaxed

AMP-binding (475..868): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHVSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

AMP-binding (2017..2397): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: gly, ala
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DILQitLIyK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 70% (weak)

swb17

Search NORINE for peptide: strict or relaxed

AMP-binding (496..902): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNFSLVWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

AMP-binding (1954..2337): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DpYWWGaTFK
Nearest Stachelhaus code:: abu
Stachelhaus code match:: 80% (moderate)