BGC0000437: syringomycin biosynthetic gene cluster from Pseudomonas syringae pv. syringae B728a
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Location: 3,060,225 - 3,182,922 nt. (total: 122,698 nt).
This entry is originally from NCBI GenBank CP000075.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000437
Short description syringomycin biosynthetic gene cluster from Pseudomonas syringae pv. syringae B728a
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP000075.1
3060225 - 3182922
via
Compounds
  • syringomycin
Species Pseudomonas syringae pv. syringae B728a [taxonomy]
References
Chemical products information
syringomycin Evidence:
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C53H85Cl1N14O17
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Psyr_2606
  • AAY37645.1
 3060225 - 3061661 (-) RND efflux system, outer membrane lipoprotein, NodT
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    • Psyr_2607
    • AAY37646.1
    		 3061640 - 3062470 (-) regulatory protein, LuxR
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      • Psyr_2608
      • AAY37647.1
      		 3062695 - 3091191 (-) Amino acid adenylation
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        • Psyr_2609
        • AAY37648.1
        		 3091468 - 3092679 (-) Alpha/beta hydrolase fold protein
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          • Psyr_2610
          • AAY37649.1
          		 3092751 - 3093683 (-) Chlorinating enzyme
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            • Psyr_2611
            • AAY37650.1
            		 3093701 - 3095545 (-) Amino acid adenylation
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              • Psyr_2612
              • AAY37651.1
              		 3095877 - 3096938 (+) alpha-ketoglutarate dependent PCP-Asp hydroxylase
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                • Psyr_2613
                • AAY37652.1
                		 3097019 - 3098719 (+) Cyclic peptide transporter
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                  • Psyr_2614
                  • AAY37653.1
                  		 3098777 - 3114895 (+) Amino acid adenylation
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                    • Psyr_2615
                    • AAY37654.1
                    		 3114892 - 3131301 (+) Amino acid adenylation
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                      • Psyr_2616
                      • AAY37655.1
                      		 3131727 - 3172340 (+) Amino acid adenylation
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                        • Psyr_2617
                        • AAY37656.1
                        		 3172404 - 3173561 (+) Secretion protein HlyD
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                          • Psyr_2618
                          • AAY37657.1
                          		 3173564 - 3175525 (+) ABC transporter:Protein of unknown function DUF214
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                            • Psyr_2619
                            • AAY37658.1
                            		 3175740 - 3177074 (-) diaminobutyrate aminotransferase apoenzyme
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                              • Psyr_2620
                              • AAY37659.1
                              		 3177351 - 3178781 (+) RND efflux system, outer membrane lipoprotein, NodT
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                                • Psyr_2621
                                • AAY37660.1
                                		 3178778 - 3179881 (+) Secretion protein HlyD
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                                  • Psyr_2622
                                  • AAY37661.1
                                  		 3179878 - 3182922 (+) Acriflavin resistance protein
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                                    Biosynthesis information

                                    Biosynthetic modules

                                    Name
                                    Unk01
                                    Type
                                    nrps-type1
                                    Genes
                                    Psyr_2608
                                    Substrates
                                    serine (evidence: ATP-PPi exchange assay [2], [11])
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Name
                                    Unk02
                                    Type
                                    nrps-type1
                                    Genes
                                    Psyr_2608
                                    Substrates
                                    serine (evidence: ATP-PPi exchange assay [3], [11])
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Name
                                    Unk03
                                    Type
                                    nrps-type1
                                    Genes
                                    Psyr_2608
                                    Substrates
                                    2,4-diaminobutyric acid (evidence: Structure-based inference [4], [11])
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Name
                                    Unk04
                                    Type
                                    nrps-type1
                                    Genes
                                    Psyr_2608
                                    Substrates
                                    2,4-diaminobutyric acid (evidence: Structure-based inference [5], [11])
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Name
                                    Unk05
                                    Type
                                    nrps-type1
                                    Genes
                                    Psyr_2608
                                    Substrates
                                    arginine (evidence: Structure-based inference [6], [11])
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Name
                                    Unk06
                                    Type
                                    nrps-type1
                                    Genes
                                    Psyr_2608
                                    Substrates
                                    phenylalanine (evidence: Structure-based inference [7], [11])
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Name
                                    Unk07
                                    Type
                                    nrps-type1
                                    Genes
                                    Psyr_2608
                                    Substrates
                                    threonine (evidence: Structure-based inference [8], [11])
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Name
                                    Unk08
                                    Type
                                    nrps-type1
                                    Genes
                                    Psyr_2608
                                    Substrates
                                    aspartic acid (evidence: ATP-PPi exchange assay [9], [11])
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Name
                                    Unk09
                                    Type
                                    nrps-type1
                                    Genes
                                    Psyr_2611
                                    Substrates
                                    threonine (evidence: ATP-PPi exchange assay, Structure-based inference)
                                    Integrated Monomers
                                    Domains
                                    adenylation
                                    Annotation changelog

                                    Entry version: next

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2024-05-14
                                    MIBiG v4 annotathon
                                    • (ID: WM5BFBJLPUJPB7YQHVARW7DU)
                                    • (ID: 7EVFL2OHJXJOBV2W5352UWGU)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 4

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-10-07
                                    Update chemical activity to schema version 2.11
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 3

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-09-15
                                    Updated bioactivity data
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    2022-09-15
                                    Added NRP substrate specificities
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 2

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2019-10-16
                                    Migrated from v1.4
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 1

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2015-06-12
                                    Submitted
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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