BGC0000438: syringopeptin 25A biosynthetic gene cluster from Pseudomonas syringae pv. syringae
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 73,800 nt. (total: 73,800 nt).
This entry is originally from NCBI GenBank AF286216.2.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000438
Short description syringopeptin 25A biosynthetic gene cluster from Pseudomonas syringae pv. syringae
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AF286216.2
via
Compounds
  • syringopeptin 25A
Species Pseudomonas syringae pv. syringae [taxonomy]
References
Chemical products information
syringopeptin 25A Evidence:
Copy SMILES
C113H183N27O30
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAF99707.2
  • sypA
 138 - 16277 (+) syringopeptin synthetase
    copy AA seq
    copy Nt seq
    • AAO72424.1
    • sypB
    		 16316 - 32689 (+) syringopeptin synthetase B
      copy AA seq
      copy Nt seq
      • AAO72425.1
      • sypC
      		 33115 - 73725 (+) syringopeptin synthetase C
        copy AA seq
        copy Nt seq
        Biosynthesis information

        Biosynthetic modules

        Name
        Unk01
        Type
        nrps-type1
        Genes
        sypA
        Substrates
        threonine (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk02
        Type
        nrps-type1
        Genes
        sypA
        Substrates
        proline (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk03
        Type
        nrps-type1
        Genes
        sypA
        Substrates
        valine (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk04
        Type
        nrps-type1
        Genes
        sypA
        Substrates
        valine (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk05
        Type
        nrps-type1
        Genes
        sypA
        Substrates
        alanine (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk06
        Type
        nrps-type1
        Genes
        sypB
        Substrates
        alanine (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk07
        Type
        nrps-type1
        Genes
        sypB
        Substrates
        valine (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk08
        Type
        nrps-type1
        Genes
        sypB
        Substrates
        valine (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk09
        Type
        nrps-type1
        Genes
        sypB
        Substrates
        threonine (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk10
        Type
        nrps-type1
        Genes
        sypB
        Substrates
        alanine (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk11
        Type
        nrps-type1
        Genes
        sypC
        Substrates
        2,4-diaminobutyric acid (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk12
        Type
        nrps-type1
        Genes
        sypC
        Substrates
        tyrosine (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk13
        Type
        nrps-type1
        Genes
        sypC
        Substrates
        alanine (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk14
        Type
        nrps-type1
        Genes
        sypC
        Substrates
        threonine (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk15
        Type
        nrps-type1
        Genes
        sypC
        Substrates
        threonine (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk16
        Type
        nrps-type1
        Genes
        sypC
        Substrates
        serine (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk17
        Type
        nrps-type1
        Genes
        sypC
        Substrates
        alanine (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk18
        Type
        nrps-type1
        Genes
        sypC
        Substrates
        threonine (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk19
        Type
        nrps-type1
        Genes
        sypC
        Substrates
        alanine (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk22
        Type
        nrps-type1
        Genes
        sypC
        Substrates
        tyrosine (evidence: Structure-based inference [1], [2])
        Integrated Monomers
        Domains
        adenylation
        Annotation changelog

        Entry version: 4

        Date
        Changes
        Submitters
        Reviewers
        2022-10-07
        Update chemical activity to schema version 2.11
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 3

        Date
        Changes
        Submitters
        Reviewers
        2022-09-15
        Updated bioactivity data
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-09-15
        Added NRP substrate specificities
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 2

        Date
        Changes
        Submitters
        Reviewers
        2019-10-16
        Migrated from v1.4
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2019-10-16
        Updated compound(s) information (NPAtlas curation)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 1

        Date
        Changes
        Submitters
        Reviewers
        2015-06-12
        Submitted
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        Detailed domain annotation
        Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
        A domain glossary is available here, and an explanation of the visualisation is available here.
        Selected features only
        Show module domains
        Similar known gene clusters from MIBiG 4.0
        Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
        Click on reference genes to show details of similarities to genes within the current region.
        Click on an accession to open that entry in the MiBIG database.