BGC0000439: taromycin A biosynthetic gene cluster from Saccharomonospora sp. CNQ490
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Location: 1 - 76,640 nt. (total: 76,640 nt).
This entry is originally from NCBI GenBank KF301601.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000439
Short description taromycin A biosynthetic gene cluster from Saccharomonospora sp. CNQ490
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Ca+-dependent lipopeptide)
Loci NCBI GenBank: KF301601.1
Compounds
  • taromycin A
Species Saccharomonospora sp. CNQ490 [taxonomy]
References
Chemical products information
taromycin A
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C70H91Cl2N17O25
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHH53496.1
 395 - 1279 (+) putative sugar kinase
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  • AHH53497.1
 1276 - 2082 (+) gluconolaconase
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  • AHH53498.1
 2095 - 3021 (-) putative oxidoreductase
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  • AHH53499.1
 3344 - 4036 (+) membrane-associated protein
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  • AHH53500.1
 3956 - 4804 (-) ABC-type multidrug transport system
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  • AHH53501.1
 4806 - 5693 (-) ABC transporter ATP-binding subunit
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  • AHH53502.1
 6079 - 7818 (+) acyl-CoA synthetase
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  • AHH53503.1
 7851 - 9569 (+) acyl-CoA dehydrogenase
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  • AHH53504.1
 9581 - 11230 (+) acyl-CoA dehydrogenase
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  • AHH53505.1
 11265 - 11528 (+) acyl carrier protein
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  • AHH53506.1
 11584 - 28905 (+) non-ribosomal peptide synthetase
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  • AHH53507.1
 28902 - 50819 (+) non-ribosomal peptide synthetase
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  • AHH53508.1
 50821 - 57978 (+) non-ribosomal peptide synthetase
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  • AHH53509.1
 57980 - 58195 (+) hypothetical protein
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  • AHH53510.1
 58210 - 59247 (+) methyltransferase
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  • AHH53511.1
 59278 - 59988 (+) tryptophan 2,3-dioxygenase
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  • AHH53512.1
 60025 - 61629 (+) tryptophan halogenase
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  • AHH53513.1
 61668 - 62204 (+) flavin reductase
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  • AHH53514.1
 62213 - 63079 (+) hypothetical protein
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  • AHH53515.1
 63152 - 63895 (+) thioesterase
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  • AHH53516.1
 63930 - 64187 (+) hypothetical protein
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  • AHH53517.1
 64279 - 67221 (+) transcriptional activator
  • Regulation
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  • AHH53518.1
 67226 - 70174 (-) luxR family transcriptional regulator
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  • AHH53519.1
 70508 - 71176 (+) O-methyltransferase
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  • AHH53520.1
 71191 - 72291 (-) methoxymalonate biosynthesis protein
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  • AHH53521.1
 72310 - 73422 (-) acyl-CoA dehydrogenase
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  • AHH53522.1
 73415 - 73699 (-) acyl carrier protein
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  • AHH53523.1
 73696 - 74559 (-) 3-hydroxyacyl-CoA dehydrogenase
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  • AHH53524.1
 74869 - 75765 (+) hypothetical protein
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  • AHH53525.1
 75766 - 76590 (-) enoyl-CoA hydratase
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NRP-specific information
Subclass Ca+-dependent lipopeptide
Cyclic? yes
Release type
  • Macrolactonization
NRP-synthases
Gene Modules
AHH53506.1
Module ?
Specificity: tryptophan
Evidence for specificity:
Module ?
Specificity: aspartic acid
Evidence for specificity:
Module ?
Specificity: aspartic acid
Evidence for specificity:
Module ?
Specificity: threonine
Evidence for specificity:
Module ?
Specificity: glycine
Evidence for specificity:
AHH53507.1
Module ?
Specificity: ornithine
Evidence for specificity:
Module ?
Specificity: aspartic acid
Evidence for specificity:
Module ?
Specificity: alanine
Evidence for specificity:
Module ?
Specificity: aspartic acid
Evidence for specificity:
Module ?
Specificity: glycine
Evidence for specificity:
Module ?
Specificity: alanine
Evidence for specificity:
AHH53508.1
Module ?
Specificity: glutamic acid
Evidence for specificity:
Module ?
Specificity: kynurenine
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: UJYWT4SZRXDY2IOPYAIF6MII, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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