Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000439.1:
Cluster 1NRP176640

BGC0000439, taromycin biosynthetic gene cluster from Saccharomonospora sp. CNQ490. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Taromycin A
SMILES string: Copy to clipboard
Molecular formula: C70H92Cl2N17O25
Exact molecular mass: 1640.58273 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
NRP
Ca+-dependent lipopeptide (cyclic)
Thioesterase type:
None
Release / cyclization type:
Macrolactonization

Gene cluster description

taromycin (BGC0000439). Gene Cluster 1. Biosynthetic class = NRP. GenBank KF301601. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Bradley Moore (Scripps Institution of Oceanography)

Literature references

1. Yamanaka K et al. (2014) Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proc Natl Acad Sci U S A 111(5):1957-62. doi: