BGC0000439: taromycin A biosynthetic gene cluster from Saccharomonospora sp. CNQ490
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Location: 1 - 76,640 nt. (total: 76,640 nt).
This entry is originally from NCBI GenBank KF301601.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000439
Short description taromycin A biosynthetic gene cluster from Saccharomonospora sp. CNQ490
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KF301601.1
via Heterologous expression
Compounds
  • taromycin A
Species Saccharomonospora sp. CNQ490 [taxonomy]
References
Chemical products information
taromycin A Evidence:
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C70H91Cl2N17O25
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHH53496.1
 395 - 1279 (+) putative sugar kinase
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    • AHH53497.1
    		 1276 - 2082 (+) gluconolaconase
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      • AHH53498.1
      		 2095 - 3021 (-) putative oxidoreductase
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        • AHH53499.1
        		 3344 - 4036 (+) membrane-associated protein
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          • AHH53500.1
          		 3956 - 4804 (-) ABC-type multidrug transport system
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            • AHH53501.1
            		 4806 - 5693 (-) ABC transporter ATP-binding subunit
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              • AHH53502.1
              		 6079 - 7818 (+) acyl-CoA synthetase
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                • AHH53503.1
                		 7851 - 9569 (+) acyl-CoA dehydrogenase
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                  • AHH53504.1
                  		 9581 - 11230 (+) acyl-CoA dehydrogenase
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                    • AHH53505.1
                    		 11265 - 11528 (+) acyl carrier protein
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                      • AHH53506.1
                      		 11584 - 28905 (+) non-ribosomal peptide synthetase
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                        • AHH53507.1
                        		 28902 - 50819 (+) non-ribosomal peptide synthetase
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                          • AHH53508.1
                          		 50821 - 57978 (+) non-ribosomal peptide synthetase
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                            • AHH53509.1
                            		 57980 - 58195 (+) hypothetical protein
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                              • AHH53510.1
                              		 58210 - 59247 (+) methyltransferase
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                                • AHH53511.1
                                		 59278 - 59988 (+) tryptophan 2,3-dioxygenase
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                                  • AHH53512.1
                                  		 60025 - 61629 (+) tryptophan halogenase
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                                    • AHH53513.1
                                    		 61668 - 62204 (+) flavin reductase
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                                      • AHH53514.1
                                      		 62213 - 63079 (+) hypothetical protein
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                                        • AHH53515.1
                                        		 63152 - 63895 (+) thioesterase
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                                          • AHH53516.1
                                          		 63930 - 64187 (+) hypothetical protein
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                                            • AHH53517.1
                                            		 64279 - 67221 (+) transcriptional activator
                                            • Regulation
                                            • Knock-out
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                                            • AHH53518.1
                                            		 67226 - 70174 (-) luxR family transcriptional regulator
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                                              • AHH53519.1
                                              		 70508 - 71176 (+) O-methyltransferase
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                                                • AHH53520.1
                                                		 71191 - 72291 (-) methoxymalonate biosynthesis protein
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                                                  • AHH53521.1
                                                  		 72310 - 73422 (-) acyl-CoA dehydrogenase
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                                                    • AHH53522.1
                                                    		 73415 - 73699 (-) acyl carrier protein
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                                                      • AHH53523.1
                                                      		 73696 - 74559 (-) 3-hydroxyacyl-CoA dehydrogenase
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                                                        • AHH53524.1
                                                        		 74869 - 75765 (+) hypothetical protein
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                                                          • AHH53525.1
                                                          		 75766 - 76590 (-) enoyl-CoA hydratase
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                                                            Biosynthesis information

                                                            Biosynthetic modules

                                                            Name
                                                            Unk01
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            AHH53506.1
                                                            Substrates
                                                            tryptophan (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk02
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            AHH53506.1
                                                            Substrates
                                                            aspartic acid (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk03
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            AHH53506.1
                                                            Substrates
                                                            aspartic acid (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk04
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            AHH53506.1
                                                            Substrates
                                                            threonine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk05
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            AHH53506.1
                                                            Substrates
                                                            glycine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk06
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            AHH53507.1
                                                            Substrates
                                                            ornithine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk07
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            AHH53507.1
                                                            Substrates
                                                            aspartic acid (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk08
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            AHH53507.1
                                                            Substrates
                                                            alanine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk09
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            AHH53507.1
                                                            Substrates
                                                            aspartic acid (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk10
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            AHH53507.1
                                                            Substrates
                                                            glycine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk11
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            AHH53507.1
                                                            Substrates
                                                            alanine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk12
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            AHH53508.1
                                                            Substrates
                                                            glutamic acid (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk13
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            AHH53508.1
                                                            Substrates
                                                            kynurenine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Annotation changelog

                                                            Entry version: 4

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-10-07
                                                            Update chemical activity to schema version 2.11
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 3

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-09-15
                                                            Updated bioactivity data
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2022-09-15
                                                            Added NRP substrate specificities
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 2

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2019-10-16
                                                            Migrated from v1.4
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 1

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2015-06-12
                                                            Submitted
                                                            • (ID: UJYWT4SZRXDY2IOPYAIF6MII)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            Detailed domain annotation
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