BGC0000441 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000441 (Actinoplanes teichomyceticus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS,T3PKS	1	89,976	High	teicoplanin	NRPS:Type I

BGC0000441 - Region 1 - NRPS,T3PKS

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Location: 1 - 89,976 nt. (total: 89,976 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 89,977
Label		BGC0000441

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

CAG15000.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CAG15002.1: dehydrogenase

smcogs: SMCOG1072: dehydrogenase

CAG15017.1: Cyclization

MITE: MITE0000038Cyclization (identity: 74.90%)
smcogs: SMCOG1007: cytochrome P450

CAG15018.1: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

CAG15019.1: Cyclization

MITE: MITE0000041Cyclization (identity: 74.10%)
smcogs: SMCOG1007: cytochrome P450

CAG15021.1: Cyclization

MITE: MITE0000027Cyclization (identity: 69.50%)
smcogs: SMCOG1007: cytochrome P450

Transferases: acyltransferase aminotransferase glycosyltransferase halogenase

CAG15008.1: Glycosylation

MITE: MITE0000034Glycosylation (identity: 100.00%)
smcogs: SMCOG1102: glycosyltransferase

CAG15020.1: flavin-dependent tyrosine-like hpg halogenase

halogenases: flavin-dependent tyrosine-like hpg halogenase
MITE: MITE0000028Halogenation (identity: 84.50%)
smcogs: SMCOG1119: halogenase

CAG15022.1: Glycosylation

MITE: MITE0000033Glycosylation (identity: 100.00%)
smcogs: SMCOG1102: glycosyltransferase

CAG15035.1: aminotransferase

smcogs: SMCOG1019: aminotransferase

teiC: polyketide synthase associated protein papA3

smcogs: SMCOG1209: polyketide synthase associated protein papA3

Hydrolases: Acylation esterase

CAG15023.1: Acylation, Hydrolysis

MITE: MITE0000035Acylation, Hydrolysis (identity: 99.40%)

CAG15042.1: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: hydratase

CAG15031.1: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

CAG15032.1: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: Acylation ligase synthase

CAG15023.1: Acylation, Hydrolysis

MITE: MITE0000035Acylation, Hydrolysis (identity: 99.40%)

CAG15025.1: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

CAG15029.1: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

teiA: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

teiB: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

teiD: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000441.4	1.16	NRPS	teicoplanin	Actinoplanes teichomyceticus
BGC0000440.5	1.07	NRPS	Teicoplanin A2-1, Teicoplanin A2-2, Teicoplanin A2-3, Teicoplanin A2-4, Teicoplanin A2-5	Actinoplanes teichomyceticus
BGC0002341.2	0.94	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608.2	0.91	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0001164.3	0.51	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.51	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002347.3	0.48	other (other)	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus caeruleus WH1-2216-6
BGC0002084.4	0.46	ribosomal	biarylitide YYH	Planomonospora sp. ID82291
BGC0002099.3	0.46	ribosomal	biarylitide YFH	Planomonospora sp. ID107089
BGC0001261.3	0.45	NRPS	AM-toxin	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000441.4	0.99	NRPS	teicoplanin	Actinoplanes teichomyceticus
BGC0000440.5	0.92	NRPS	Teicoplanin A2-1, Teicoplanin A2-2, Teicoplanin A2-3, Teicoplanin A2-4, Teicoplanin A2-5	Actinoplanes teichomyceticus
BGC0002341.2	0.77	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608.2	0.76	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0001261.3	0.75	NRPS	AM-toxin	Alternaria alternata
BGC0001249.5	0.75	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001132.4	0.74	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002135.2	0.73	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 87559:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Hpg - D-Tyr) + (Dhpg) + (D-Hpg - D-Hpg - Tyr) + (Dhpg)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 61276:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Hpg - D-Tyr) + (Dhpg) + (D-Hpg - D-Hpg - Tyr) + (Dhpg)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

teiA: Hpg - Tyr

Search NORINE for peptide: strict or relaxed

AMP-binding (15..402): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFHLGLLCK
Nearest Stachelhaus code(s):: Hpg DAFHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1037..1423): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DASTVAAVCK
Nearest Stachelhaus code(s):: Tyr DASTVAAVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

teiB: Dhpg

Search NORINE for peptide: strict or relaxed

AMP-binding (466..854): Dhpg

nrpys: Dhpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: dhpg (Dhpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DAYNLGTLCK
Nearest Stachelhaus code(s):: Dhpg DAYNLGTLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

teiC: Hpg - Hpg - Tyr

Search NORINE for peptide: strict or relaxed

AMP-binding (459..852): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DIFHLGLLCK
Nearest Stachelhaus code(s):: Hpg DIFHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1956..2348): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: hpg (Hpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DALHLGLLCK
Nearest Stachelhaus code(s):: Hpg DALHLGLLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3467..3853): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: bht (bOH-Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DASTIAGVCK
Nearest Stachelhaus code(s):: Tyr DASTIAGVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

teiD: Dhpg

Search NORINE for peptide: strict or relaxed

AMP-binding (470..870): Dhpg

nrpys: Dhpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: Polar, uncharged (hydroxy-phenyl) (Dhpg, Hpg)
Single AA prediction:: dhpg (Dhpg)

Stachelhaus prediction details:

Stachelhaus sequence:: DPYHGGTLCK
Nearest Stachelhaus code(s):: Dhpg DPYHGGTLCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

CAG15025.1: NH2

CAL_domain (40..467): NH2

minowa: NH2

Prediction, score:

NH2: 94.7
fatty_acid: 48.3
AHBA: 3.8
Acetyl-CoA: 3.4
shikimic_acid: 0.0

Link to PARAS substrate predictor