BGC0000445: thiocoraline biosynthetic gene cluster from Micromonospora sp. ML1
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Location: 1 - 64,650 nt. (total: 64,650 nt).
This entry is originally from NCBI GenBank AM113472.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000445
Short description thiocoraline biosynthetic gene cluster from Micromonospora sp. ML1
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
Loci NCBI GenBank: AM113472.1
Compounds
  • thiocoraline
Species Micromonospora sp. ML1 [taxonomy]
References
Chemical products information
thiocoraline
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C48H56N10O12S6
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAJ34355.1
 2 - 538 (+) putative transposase
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  • CAJ34356.1
 990 - 1130 (-) hypothetical protein
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  • CAJ34357.1
  • tioA
 1517 - 2134 (+) OmpR family regulator
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  • CAJ34358.1
  • tioB
 2151 - 2822 (-) putative regulator
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  • CAJ34359.1
  • tioC
 2967 - 3791 (-) ABC transporter (permease subunit)
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  • CAJ34360.1
  • tioD
 3791 - 4777 (-) ABC transporter (ATPase subunit)
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  • CAJ34361.1
  • tioE
 4904 - 5614 (+) MerR family regulator
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  • CAJ34362.1
  • tioF
 5698 - 6426 (-) Tryptophan 2,3-dioxygenase
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  • CAJ34363.1
  • tioG
 6423 - 7688 (-) kynurenine aminotransferase
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  • CAJ34364.1
  • tioH
 7730 - 8524 (-) NAD or NADP oxidoreductase
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  • CAJ34365.1
  • tioI
 8791 - 10005 (+) quinaldate 3-hydroxylase
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  • CAJ34366.1
  • tioJ
 10019 - 11590 (-) putative 3-hydroxy-quinaldate-AMP-Ligase
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  • CAJ34367.1
  • tioK
 11847 - 13637 (+) NRPS protein
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  • CAJ34368.1
  • tioL
 13731 - 15005 (-) hypothetical protein
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  • CAJ34369.1
  • tioM
 15002 - 16354 (-) V-chloroperoxidase
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  • CAJ34370.1
  • tioN
 16438 - 18744 (-) NRPS protein
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  • CAJ34371.1
  • tioO
 18771 - 19055 (-) putative 3-hydroxy-quinaldate Carrier Protein
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  • CAJ34372.1
  • tioP
 19260 - 20039 (+) thioesterase
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  • CAJ34373.1
  • tioQ
 20143 - 20880 (-) thioesterase
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  • CAJ34374.1
  • tioR
 21188 - 28972 (+) NRPS protein
  • Scaffold biosynthesis
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  • CAJ34375.1
  • tioS
 28979 - 38401 (+) NRPS
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  • CAJ34376.1
  • tioT
 38449 - 38664 (+) MbtH homologue
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  • CAJ34377.1
  • tioU
 38642 - 41266 (+) DNA excisionase
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  • CAJ34378.1
  • tioV
 41835 - 42371 (+) OmpR family regulator
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  • CAJ34379.1
  • tioW
 42392 - 43255 (-) putative regulator
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  • CAJ34380.1
  • tioX
 43337 - 43741 (-) hypothetical protein
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  • CAJ34381.1
  • tioY
 44152 - 49566 (+) NRPS protein
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  • CAJ34382.1
  • tioZ
 49635 - 53672 (+) NRPS protein
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  • CAJ34383.1
 53746 - 55305 (-) putative permease for glucides
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  • CAJ34384.1
 55381 - 57222 (-) putative permease for glucides
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  • CAJ34385.1
 57895 - 58470 (+) putative MarR family regulator
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  • CAJ34386.1
 58532 - 59206 (-) putative anti-sigma factor
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  • CAJ34387.1
 59295 - 59564 (-) hypothetical protein
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  • CAJ34388.1
 59608 - 60114 (-) putative anti-sigma factor
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  • CAJ34389.1
 60202 - 60891 (+) putative response regulator
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  • CAJ34390.1
 60960 - 62243 (+) putative histidine kinase
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  • CAJ34391.1
 62300 - 62836 (+) hypothetical protein
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  • CAJ34392.1
 62925 - >64650 (+) putative chaperone
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NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Release type
  • Hydrolysis
NRP-synthases
Gene Modules
tioR
Module 1
Specificity: cysteine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Unknown
Module 2
Specificity: glycine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Unknown
tioS
Module 3
Specificity: cysteine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Unknown
Modification domains: Methylation
Module 4
Specificity: cysteine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Unknown
Modification domains: Methylation
tioL
Module 0
Condensation domain type: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: IROSGRAECON7XFWB774QFHDN, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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