BGC0000447: tolaasin I biosynthetic gene cluster from Pseudomonas costantinii
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Location: 1 - 69,124 nt. (total: 69,124 nt).
This entry is originally from NCBI GenBank HE967327.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
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Gene details
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General
Compounds
Genes
NRP
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000447
Short description tolaasin I biosynthetic gene cluster from Pseudomonas costantinii
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Other lipopeptide)
Loci NCBI GenBank: HE967327.1
Compounds
  • tolaasin I
  • tolaasin F
Species Pseudomonas costantinii [taxonomy]
References
Chemical products information
tolaasin I
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C94H163N21O25
Chemical database entries
PubCHEM
ChemSpider
tolaasin F
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C94H163N21O25
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CCJ67633.1
  • mepC
1 - 1440 (-) multidrug/solvent efflux pump outer membrane protein mepC
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  • CCJ67634.1
1503 - 2384 (-) bacterial regulatory, luxR family protein
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  • CCJ67635.1
2636 - 4333 (+) cyclic peptide transporter family protein
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  • CCJ67636.1
  • taaA
4795 - 14454 (+) TaaA
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  • CCJ67637.1
  • taaB
14451 - 24293 (+) TaaB
  • Scaffold biosynthesis
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  • CCJ67638.1
  • taaC
24290 - 34258 (+) TaaC
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  • CCJ67639.1
  • taaD
34255 - 44247 (+) TaaD
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  • CCJ67640.1
  • taaE
44558 - 65716 (+) TaaE
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  • CCJ67641.1
  • macA
65838 - 66989 (+) macrolide-specific efflux protein macA
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  • CCJ67642.1
  • macB
66992 - 68950 (+) macrolide export ATP-binding/permease protein MacB
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NRP-specific information
Subclass Other lipopeptide
Cyclic? yes
Release type
  • Macrolactonization
Lipid moiety beta-hydroxy-octanoic acid
Thioesterase genes
  • CCJ67640.1 (Type I)
NRP-synthases
Gene Modules
CCJ67636.1
Module 1
Specificity: Threonine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Starter
Modification domains: dehydration
Module 2
Specificity: Proline
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Module 3
Specificity: Serine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
CCJ67637.1
Module 4
Specificity: Leucine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Module 5
Specificity: Valine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Module 6
Specificity: Serine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
CCJ67638.1
Module 7
Specificity: Leucine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Module 8
Specificity: Valine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Module 9
Specificity: Valine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
CCJ67639.1
Module 10
Specificity: Glutamine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Module 11
Specificity: Leucine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Module 12
Specificity: Valine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Unknown
CCJ67640.1
Module 13
Specificity: Threonine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Modification domains: dehydration
Module 14
Specificity: Threonine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Module 15
Specificity: Leucine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Module 16
Specificity: Homoserine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 17
Specificity: 2,4-Diaminobutyric acid
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 18
Specificity: Lysine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: DCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: F65XGYSSLMUEJC2Q4T3BLCPS, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
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Detailed domain annotation
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