Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000465.1:
Cluster 1NRP110043

BGC0000465, xenortide biosynthetic gene cluster from Xenorhabdus nematophila. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Xenortide A
PubChem ID: 24900168
SMILES string: Copy to clipboard
Molecular formula: C25H35N3O2
Average molecular mass: 409.574 Da
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
Other (linear)
Thioesterase type:
Release / cyclization type:

Gene cluster description

xenortide (BGC0000465). Gene Cluster 1. Biosynthetic class = NRP. GenBank FN667742, positions 2245621-2235579. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
Contact for this cluster:Helge Bode (Goethe Universitaet Frankfurt)

Literature references

1. Reimer D et al. (2014) Xenortide Biosynthesis by Entomopathogenic Xenorhabdus nematophila. J Nat Prod 77(8):1976-80. doi: 10.1021/np500390b.
2. Lang G et al. (2008) Linear and cyclic peptides from the entomopathogenic bacterium Xenorhabdus nematophilus. J Nat Prod 71(6):1074-7. doi: 10.1021/np800053n. Epub 2008 May 21.
3. Crawford JM et al. (2011) NRPS substrate promiscuity diversifies the xenematides. Org Lett 13(19):5144-7. doi: 10.1021/ol2020237. Epub 2011 Sep 2.