BGC0000497 - 1 region(s) - antiSMASH results

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	11,249	High	BHT-Aα/BHT-Aβ	ribosomal:RiPP:Lanthipeptide

Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 11,250
Label		BGC0000497

Tailoring functions

Lyases: cyclase

bhtM1: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

bhtM2: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000497.3	1.00	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000552.3	0.91	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0000623.3	0.53	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002663.2	0.53	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000626.3	0.52	ribosomal	thuricin	Bacillus thuringiensis
BGC0002698.2	0.52	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001229.4	0.52	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000521.3	0.50	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0001311.5	0.50	ribosomal	flavecins	Ruminococcus flavefaciens FD-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000497.3	1.00	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000552.3	0.91	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0000623.3	0.53	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002663.2	0.53	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000626.3	0.52	ribosomal	thuricin	Bacillus thuringiensis
BGC0002698.2	0.52	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001229.4	0.52	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000521.3	0.50	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0001311.5	0.50	ribosomal	flavecins	Ruminococcus flavefaciens FD-1

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for bhtM1

bhtA_beta

Leader:

MKSNLLKINNVTEVEKDMVTLIKDEDMELAGG

Core:

STPACAIGVVGITVAVTGISTACTSRCINK

Core with dehydrations:

DhaDhbPACysAIGVVGIDhbVAVDhbGIDhaDhbACysDhbDhaRCysINK

antiSMASH-DB 4.0 matches for bhtA_beta

100.0%

NC_018089.1and 13 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08730_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04350_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04350_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09070_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09070_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00320_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00320_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03990_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03990_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08125_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08125_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05520_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05520_lanthipeptide

Lanthipeptides: SMUGS5_RS08730_lanthipeptide

1

STPACAIGVVGITVAVTGISTACTSRCINK

30

STPACAIGVVGITVAVTGISTACTSRCINK

1

STPACAIGVVGITVAVTGISTACTSRCINK

30

43.3%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

2

TPACAIGVVGITVAVTGISTACTSRC

27

TPA +I V G T STACT C

2

TPAISILVSGFISTNTCPSTACTRAC

27

40.6%

NZ_NUML01000015.1:

Lanthipeptides: COD66_RS20140_lanthipeptide

1

STPACAIGVVGITVAVTGISTACTSRC

27

+TPA VVGI+V + +T CTS+C

7

TTPATPTIVVGISVGLCP-TTKCTSKC

32

with 19 more sequence matches

Only the first 10 are displayed here.

40.0%

NZ_JAMXMK010000009.1:

Lanthipeptides: NGM22_RS28125_lanthipeptide

1

STPACAIGVVGITVAVTGISTACTSRC

27

STPACA VG+T+A G C

7

STPACA---VGVTIAAWGAHKLSYWNC

30

39.4%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00700_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00700_lanthipeptide

1

STPACA---IGVVGITVAVTGISTACTSRCIN

29

STP CA + + A+ I+TACT+RC +

1

STPGCAWAAVSAISTVSALFQITTACTTRCYH

32

37.5%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

1

STPACAIGVVGITVAVTGISTACTSRC

27

+TPA VV I+V + +T CTS+C

7

TTPATPTIVVAISVGLCP-TTKCTSKC

32

31.4%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

9

VVGITVAVTG---ISTACTSRC

27

++G T+AVT +T CTSRC

14

IIGATIAVTASLCPTTKCTSRC

35

31.0%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

5

CAIG--VVGITVAVTGIS------TACTSRC

27

CA+G VGIT+ S +AC+SRC

11

CAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

30.0%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide

Lanthipeptides: LDO05_RS02090_lanthipeptide

9

VVGITVAVTGISTACTSRC

27

+ G+ A STACTS+C

10

ICGVASAAFCPSTACTSKC

28

26.7%

NC_014622.2and 5 others:

NC_017542.1 Lanthipeptides: PPM_RS22280_lanthipeptideNZ_CP029370.1 Lanthipeptides: DI243_RS20990_lanthipeptideNZ_CP034141.1 Lanthipeptides: EGM68_RS21685_lanthipeptideNZ_PNXP01000027.1 Lanthipeptides: C1I59_RS20700_lanthipeptideNZ_POVS01000032.1 Lanthipeptides: C1T21_RS26405_lanthipeptide

Lanthipeptides: PPSC2_RS50140_lanthipeptide

1

STPACAIGVVGITVAV

16

STP + V+G+TV V

7

STPTITVTVIGVTVLV

22

26.7%

NZ_CM000752.1and 15 others:

NZ_CM000752.1 Sactipeptides: BTHUR0007_RS37430_sactipeptideNZ_JABGBR020000007.1 Sactipeptides: HOV72_RS15955_sactipeptideNZ_JABGBR020000007.1 Sactipeptides: HOV72_RS15950_sactipeptideNZ_JYPH01000039.1 Sactipeptides: TU52_RS33370_sactipeptideNZ_JYPH01000039.1 Sactipeptides: TU52_RS33365_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29070_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29065_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29060_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31360_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31355_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31350_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30820_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30815_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30810_sactipeptideNZ_NUXK01000018.1 Sactipeptides: COJ27_RS31850_sactipeptide

Sactipeptides: BTHUR0007_RS37435_sactipeptide

4

ACAIGVVGITVAVTGISTA

22

AC++ ++ + A TG STA

11

ACSVELLNLVTAATGASTA

29

26.7%

NZ_JAQQWR010000009.1:

Lanthipeptides: PQ473_RS20135_lanthipeptide

1

STPACAIGVVGITVAVTGIS

20

+TPAC G + IT+ V ++

7

TTPACIYGGIAITIGVVSVA

26

25.6%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide

Lanthipeptides: P40081_RS37160_lanthipeptide

5

CAIGVVGITVAVTGISTACTSRC

27

C IG V I+ + +T CTS+C

18

CVIGAVDISANLCP-TTKCTSKC

39

MIBiG 4.0 matches for bhtA_beta

16.7%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

20

STACTSRC

27

+T CTS+C

19

TTKCTSKC

26

16.2%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

20

STACTSRC

27

+T CTSRC

30

TTKCTSRC

37

bhtA_alpha

Leader:

MKEIQKAGLQEELSILMDDANNLEQLTAG

Core:

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCQ

Core with dehydrations:

IGDhbDhbVVNDhaDhbFDhaIVLGNKGYICysDhbVDhbVECysMRNCysQ

antiSMASH-DB 4.0 matches for bhtA_alpha

100.0%

NZ_CP043405.1and 1 other:

NZ_CP043405.1 Lanthipeptides: FY406_RS04355_lanthipeptide

Lanthipeptides: FY406_RS04355_lanthipeptide

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCQ

32

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCQ

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCQ

32

93.9%

NC_018089.1and 11 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08725_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptide

Lanthipeptides: SMUGS5_RS08725_lanthipeptide

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCQ

32

IGTTVVNSTFSIVLGNKGYICTVTVECMRNC

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCS

32

52.9%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide

Lanthipeptides: IE257_RS28650_lanthipeptide

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCQ

32

I TV + S LGN G++CTVTVEC +NCQ

2

IFETVTYTVASWALGNNGHLCTVTVECQKNCQ

33

with 100 more sequence matches

Only the first 10 are displayed here.

50.0%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNCQ

32

+TFS+ VLGN G CT+TVEC NC

4

NTFSLSDVLGNTGGWCTLTVECQPNCN

30

50.0%

NZ_KV795763.1and 2 others:

NZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptideNZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptide

Lanthipeptides: allorf_248182_248337_lanthipeptide

4

TVVNSTFSIVLGNKGYICTVTVECMRNCQ

32

T +S V+GN+G +CTVTVECM CQ

1

TAFPGWYSKVIGNRGRVCTVTVECMSVCQ

29

48.6%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

1

IGTTVVNST---FSIVLGNKGYICTVTVECMRNCQ

32

IGTTV + S LGN G CT TVEC NC+

3

IGTTVTTLSCYGVSWALGNDGNFCTATVECQSNCK

37

46.9%

NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide

Lanthipeptides: GTU71_RS12805_lanthipeptide

9

TFSIVLGNKGYICTVTVECMRNCQ

32

T S VLGN+G CT+TVEC NC+

7

TLSNVLGNQGGWCTLTVECQPNCK

30

43.8%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

11

SIVLGNKGYICTVTVECMRNCQ

32

S LGNKG CT+TVECM +C

11

SCRLGNKGAYCTLTVECMPSCN

32

43.8%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20295_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptide

Lanthipeptides: BLI_RS20295_lanthipeptide

10

FSIVLGNKGYICTVTVECMRNCQ

32

S LGN GY+CTVT ECM +C

10

LSKPLGNNGYLCTVTKECMPSCN

32

43.8%

NC_018499.1and 10 others:

NC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27860_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25275_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25270_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27570_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27565_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27560_lanthipeptide

Lanthipeptides: BCK_RS27860_lanthipeptide

5

VVNSTFSIVLGNKGYICTVTVECMRNC

31

V S LGNKG CT+T ECM +C

5

VTPEGLSSWLGNKGGYCTLTKECMPSC

31

43.8%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06515_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide

Lanthipeptides: PO853_RS06515_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNCQ

32

+TFS+ GNKG CT T ECM C+

4

NTFSLSDYWGNKGNWCTATHECMGWCK

30

43.8%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNC

31

+TFS+ LGN G CT+T EC NC

4

NTFSLSDALGNHGGWCTLTKECQANC

29

43.8%

NZ_BLIS01000009.1and 7 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide

Lanthipeptides: GVO03_RS04820_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNCQ

32

+TFS+ GNKG CT+T ECM C+

4

NTFSLSDYWGNKGNWCTLTHECMNWCK

30

MIBiG 4.0 matches for bhtA_alpha

43.8%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

11

SIVLGNKGYICTVTVECMRNCQ

32

S LGNKG CT+TVECM +C

7

SCRLGNKGAYCTLTVECMPSCN

28

43.8%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

8

STFSI--VLGNKGYICTVTVECMRNCQ

32

+TFS+ LGN G CT+T EC NC

4

NTFSLSNALGNNGGWCTLTKECQPNCN

30

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

21

CTVTVECMRNC

31

CT++ EC NC

28

CTLSKECQPNC

38

Lanthipeptide(s) for bhtM2

bhtA_beta

Leader:

MKSNLLKINNVTEVEKDMVTLIKDEDMELAGG

Core:

STPACAIGVVGITVAVTGISTACTSRCINK

Core with dehydrations:

DhaDhbPACysAIGVVGIDhbVAVDhbGIDhaDhbACysDhbDhaRCysINK

antiSMASH-DB 4.0 matches for bhtA_beta

100.0%

NC_018089.1and 13 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08730_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04350_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04350_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09070_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09070_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00320_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00320_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03990_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03990_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08125_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08125_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05520_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05520_lanthipeptide

Lanthipeptides: SMUGS5_RS08730_lanthipeptide

1

STPACAIGVVGITVAVTGISTACTSRCINK

30

STPACAIGVVGITVAVTGISTACTSRCINK

1

STPACAIGVVGITVAVTGISTACTSRCINK

30

43.3%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

2

TPACAIGVVGITVAVTGISTACTSRC

27

TPA +I V G T STACT C

2

TPAISILVSGFISTNTCPSTACTRAC

27

40.6%

NZ_NUML01000015.1:

Lanthipeptides: COD66_RS20140_lanthipeptide

1

STPACAIGVVGITVAVTGISTACTSRC

27

+TPA VVGI+V + +T CTS+C

7

TTPATPTIVVGISVGLCP-TTKCTSKC

32

with 19 more sequence matches

Only the first 10 are displayed here.

40.0%

NZ_JAMXMK010000009.1:

Lanthipeptides: NGM22_RS28125_lanthipeptide

1

STPACAIGVVGITVAVTGISTACTSRC

27

STPACA VG+T+A G C

7

STPACA---VGVTIAAWGAHKLSYWNC

30

39.4%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00700_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00700_lanthipeptide

1

STPACA---IGVVGITVAVTGISTACTSRCIN

29

STP CA + + A+ I+TACT+RC +

1

STPGCAWAAVSAISTVSALFQITTACTTRCYH

32

37.5%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

1

STPACAIGVVGITVAVTGISTACTSRC

27

+TPA VV I+V + +T CTS+C

7

TTPATPTIVVAISVGLCP-TTKCTSKC

32

31.4%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

9

VVGITVAVTG---ISTACTSRC

27

++G T+AVT +T CTSRC

14

IIGATIAVTASLCPTTKCTSRC

35

31.0%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

5

CAIG--VVGITVAVTGIS------TACTSRC

27

CA+G VGIT+ S +AC+SRC

11

CAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

30.0%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide

Lanthipeptides: LDO05_RS02090_lanthipeptide

9

VVGITVAVTGISTACTSRC

27

+ G+ A STACTS+C

10

ICGVASAAFCPSTACTSKC

28

26.7%

NC_014622.2and 5 others:

NC_017542.1 Lanthipeptides: PPM_RS22280_lanthipeptideNZ_CP029370.1 Lanthipeptides: DI243_RS20990_lanthipeptideNZ_CP034141.1 Lanthipeptides: EGM68_RS21685_lanthipeptideNZ_PNXP01000027.1 Lanthipeptides: C1I59_RS20700_lanthipeptideNZ_POVS01000032.1 Lanthipeptides: C1T21_RS26405_lanthipeptide

Lanthipeptides: PPSC2_RS50140_lanthipeptide

1

STPACAIGVVGITVAV

16

STP + V+G+TV V

7

STPTITVTVIGVTVLV

22

26.7%

NZ_CM000752.1and 15 others:

NZ_CM000752.1 Sactipeptides: BTHUR0007_RS37430_sactipeptideNZ_JABGBR020000007.1 Sactipeptides: HOV72_RS15955_sactipeptideNZ_JABGBR020000007.1 Sactipeptides: HOV72_RS15950_sactipeptideNZ_JYPH01000039.1 Sactipeptides: TU52_RS33370_sactipeptideNZ_JYPH01000039.1 Sactipeptides: TU52_RS33365_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29070_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29065_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29060_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31360_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31355_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31350_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30820_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30815_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30810_sactipeptideNZ_NUXK01000018.1 Sactipeptides: COJ27_RS31850_sactipeptide

Sactipeptides: BTHUR0007_RS37435_sactipeptide

4

ACAIGVVGITVAVTGISTA

22

AC++ ++ + A TG STA

11

ACSVELLNLVTAATGASTA

29

26.7%

NZ_JAQQWR010000009.1:

Lanthipeptides: PQ473_RS20135_lanthipeptide

1

STPACAIGVVGITVAVTGIS

20

+TPAC G + IT+ V ++

7

TTPACIYGGIAITIGVVSVA

26

25.6%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide

Lanthipeptides: P40081_RS37160_lanthipeptide

5

CAIGVVGITVAVTGISTACTSRC

27

C IG V I+ + +T CTS+C

18

CVIGAVDISANLCP-TTKCTSKC

39

MIBiG 4.0 matches for bhtA_beta

16.7%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

20

STACTSRC

27

+T CTS+C

19

TTKCTSKC

26

16.2%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

20

STACTSRC

27

+T CTSRC

30

TTKCTSRC

37

bhtA_alpha

Leader:

MKEIQKAGLQEELSILMDDANNLEQLTAG

Core:

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCQ

Core with dehydrations:

IGDhbDhbVVNDhaDhbFDhaIVLGNKGYICysDhbVDhbVECysMRNCysQ

antiSMASH-DB 4.0 matches for bhtA_alpha

100.0%

NZ_CP043405.1and 1 other:

NZ_CP043405.1 Lanthipeptides: FY406_RS04355_lanthipeptide

Lanthipeptides: FY406_RS04355_lanthipeptide

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCQ

32

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCQ

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCQ

32

93.9%

NC_018089.1and 11 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08725_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptide

Lanthipeptides: SMUGS5_RS08725_lanthipeptide

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCQ

32

IGTTVVNSTFSIVLGNKGYICTVTVECMRNC

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCS

32

52.9%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide

Lanthipeptides: IE257_RS28650_lanthipeptide

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCQ

32

I TV + S LGN G++CTVTVEC +NCQ

2

IFETVTYTVASWALGNNGHLCTVTVECQKNCQ

33

with 100 more sequence matches

Only the first 10 are displayed here.

50.0%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNCQ

32

+TFS+ VLGN G CT+TVEC NC

4

NTFSLSDVLGNTGGWCTLTVECQPNCN

30

50.0%

NZ_KV795763.1and 2 others:

NZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptideNZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptide

Lanthipeptides: allorf_248182_248337_lanthipeptide

4

TVVNSTFSIVLGNKGYICTVTVECMRNCQ

32

T +S V+GN+G +CTVTVECM CQ

1

TAFPGWYSKVIGNRGRVCTVTVECMSVCQ

29

48.6%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

1

IGTTVVNST---FSIVLGNKGYICTVTVECMRNCQ

32

IGTTV + S LGN G CT TVEC NC+

3

IGTTVTTLSCYGVSWALGNDGNFCTATVECQSNCK

37

46.9%

NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide

Lanthipeptides: GTU71_RS12805_lanthipeptide

9

TFSIVLGNKGYICTVTVECMRNCQ

32

T S VLGN+G CT+TVEC NC+

7

TLSNVLGNQGGWCTLTVECQPNCK

30

43.8%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

11

SIVLGNKGYICTVTVECMRNCQ

32

S LGNKG CT+TVECM +C

11

SCRLGNKGAYCTLTVECMPSCN

32

43.8%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20295_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptide

Lanthipeptides: BLI_RS20295_lanthipeptide

10

FSIVLGNKGYICTVTVECMRNCQ

32

S LGN GY+CTVT ECM +C

10

LSKPLGNNGYLCTVTKECMPSCN

32

43.8%

NC_018499.1and 10 others:

NC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27860_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25275_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25270_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27570_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27565_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27560_lanthipeptide

Lanthipeptides: BCK_RS27860_lanthipeptide

5

VVNSTFSIVLGNKGYICTVTVECMRNC

31

V S LGNKG CT+T ECM +C

5

VTPEGLSSWLGNKGGYCTLTKECMPSC

31

43.8%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06515_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide

Lanthipeptides: PO853_RS06515_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNCQ

32

+TFS+ GNKG CT T ECM C+

4

NTFSLSDYWGNKGNWCTATHECMGWCK

30

43.8%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNC

31

+TFS+ LGN G CT+T EC NC

4

NTFSLSDALGNHGGWCTLTKECQANC

29

43.8%

NZ_BLIS01000009.1and 7 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide

Lanthipeptides: GVO03_RS04820_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNCQ

32

+TFS+ GNKG CT+T ECM C+

4

NTFSLSDYWGNKGNWCTLTHECMNWCK

30

MIBiG 4.0 matches for bhtA_alpha

43.8%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

11

SIVLGNKGYICTVTVECMRNCQ

32

S LGNKG CT+TVECM +C

7

SCRLGNKGAYCTLTVECMPSCN

28

43.8%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

8

STFSI--VLGNKGYICTVTVECMRNCQ

32

+TFS+ LGN G CT+T EC NC

4

NTFSLSNALGNNGGWCTLTKECQPNCN

30

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

21

CTVTVECMRNC

31

CT++ EC NC

28

CTLSKECQPNC

38

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Identified secondary metabolite regions using strictness 'relaxed'

Legend:

Lanthipeptide(s) for bhtM1

antiSMASH-DB 4.0 matches for bhtA_beta

MIBiG 4.0 matches for bhtA_beta

antiSMASH-DB 4.0 matches for bhtA_alpha

MIBiG 4.0 matches for bhtA_alpha

Lanthipeptide(s) for bhtM2

antiSMASH-DB 4.0 matches for bhtA_beta

MIBiG 4.0 matches for bhtA_beta

antiSMASH-DB 4.0 matches for bhtA_alpha

MIBiG 4.0 matches for bhtA_alpha

Legend: