BGC0000501 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000501 (Catenulispora acidiphila DSM 44928)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-iii	1	22,613	High	catenulipeptin	ribosomal:RiPP:Lanthipeptide

BGC0000501 - Region 1 - lanthipeptide-class-iii

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Location: 1 - 22,613 nt. (total: 22,613 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 22,614
Label		BGC0000501

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000501.3	1.00	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000496.5	0.66	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000551.5	0.65	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.61	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000519.4	0.60	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000553.3	0.54	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0002698.2	0.52	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000518.3	0.49	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000546.3	0.48	ribosomal	SAL-2242	Streptomyces albidoflavus
BGC0002111.3	0.47	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000501.3	1.00	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000496.5	0.66	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000551.5	0.65	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.61	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000519.4	0.60	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000553.3	0.54	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0002698.2	0.52	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000518.3	0.49	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000546.3	0.48	ribosomal	SAL-2242	Streptomyces albidoflavus
BGC0002111.3	0.47	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for Caci_4239

Caci_4240

Leader:

MTEEMTLLDLQGMEQTETDSWGGSGH

Core:

GGGGDSGLSVTGCNGHSGISLLCDL

Core with dehydrations:

GGGGDDhaGLDhaVDhbGCysNGHDhaGIDhaLLCysDL

antiSMASH-DB 4.0 matches for Caci_4240

100.0%

NC_013131.1:

Lanthipeptides: CACI_RS49205_lanthipeptide

GGGGDSGLSVTGCNGHSGISLLCDL

52.0%

NZ_CP007155.1:

Lanthipeptides: KALB_RS46315_lanthipeptide

GDSGLSVTGCNGHSGISLL

G S LSV+GC G SG+SLL

GGSHLSVSGCGGASGLSLL

48.1%

NZ_JACDUR010000003.1and 1 other:

NZ_JACDUR010000003.1 Lanthipeptides: HNR30_RS17930_lanthipeptide

Lanthipeptides: HNR30_RS17930_lanthipeptide

GGGGDSGLSVTGCNGH--SGISLL

G GG S L+V GCN + S +SLL

GHGGGSTLTVLGCNSYTPSNLSLL

with 57 more sequence matches

Only the first 10 are displayed here.

48.0%

NZ_CP022753.1and 1 other:

NZ_CP022753.1 Lanthipeptides: CDO52_RS14300_lanthipeptide

Lanthipeptides: CDO52_RS14300_lanthipeptide

DSGLSVTGCNGHSGIS-LLCD

+S LSV C G S +S LLCD

ESRLSVITCGGLSQLSALLCD

48.0%

NZ_JABBWU010000019.1and 1 other:

NZ_JABBWU010000019.1 Lanthipeptides: HHX30_RS29850_lanthipeptide

Lanthipeptides: HHX30_RS29860_lanthipeptide

GGDSGLSVTGCNGH--SGISLLC

GG S LS+ GC H S +SL+C

GGGSNLSLLGCTPHENSSLSLIC

48.0%

NZ_PGGV01000004.1:

Lanthipeptides: CUT39_RS01870_lanthipeptide

SGLSVTGCNGHSGIS-LLCD

S LSVT C+G S +S LLC+

SNLSVTLCDGTSRLSVLLCE

46.2%

NC_013595.1:

Lanthipeptides: SROS_RS48825_lanthipeptide

GGGDSGLSVTGCNGH--SGISLL

GGG S L+V GC + S +SLL

GGGGSTLTVLGCESYKPSNLSLL

46.2%

NZ_CP043661.1and 1 other:

NZ_SOCE01000001.1 Lanthipeptides: EV138_RS20105_lanthipeptide

Lanthipeptides: F1D05_RS17325_lanthipeptide

GGDSGLSVTGCNGH--SGISLL

GG S L+V GC H S +SLL

GGGSTLTVLGCASHTPSNLSLL

46.2%

NZ_CP114065.1:

Lanthipeptides: OX958_RS15815_lanthipeptide

GGGDSGLSVTGCNGH--SGISLL

GGG S L+V GC S ISL+

GGGGSTLTVLGCESKTPSNISLV

44.0%

NC_016582.1:

Lanthipeptides: SBI_RS53340_lanthipeptide

GGDSGLSVTGCNGHSGIS-LLC

GG+S +S+ C+ HS S LLC

GGESSVSLLLCDKHSSHSNLLC

44.0%

NZ_BCBX01000043.1:

Lanthipeptides: AP234_RS36585_lanthipeptide

GDSGLSVTGCNGH--SGISLLC

G S LS+ C H S +SLLC

GGSNLSLLACVPHENSSLSLLC

44.0%

NZ_BMRB01000005.1and 1 other:

NZ_CP031087.1 Lanthipeptides: Actkin_RS09240_lanthipeptide

Lanthipeptides: IEY98_RS25135_lanthipeptide

GGGDSGLSVTGCNGHSGISLL

GGG S LS+ +S ISLL

GGGASNLSLIASCANSTISLL

44.0%

NZ_FOQY01000005.1:

Lanthipeptides: BM085_RS08660_lanthipeptide

GGDSGLSVTGCNGH--SGISLL

GG S L+V GC + S +SLL

GGGSTLTVLGCESYKPSNLSLL

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

Caci_4240 - Class III

Cleavage pHMM score: 3.50

RODEO score: 0

Monoisotopic mass: 2185.0 Da

Molecular weight: 2186.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2204.4 Da N = 1; 2222.4 Da N = 2; 2240.4 Da N = 3