BGC0000521 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000521 (Lactococcus lactis subsp. lactis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-ii	1	12,132	lacticin 481	ribosomal:RiPP:Lanthipeptide	100%

BGC0000521 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 12,132 nt. (total: 12,132 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 12,133
Label		BGC0000521

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000499	0.42	RiPP	butyrivibriocin OR79	Butyrivibrio fibrisolvens
BGC0000562	0.38	RiPP	variacin	Kocuria varians
BGC0000521	0.36	RiPP	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000626	0.36	RiPP	thuricin	Bacillus thuringiensis
BGC0000532	0.33	RiPP	mutacin II	Streptococcus mutans
BGC0000539	0.31	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0002630	0.31	RiPP	thatisin	Lysobacter antibioticus
BGC0001787	0.29	RiPP	suicin 3908	Streptococcus suis
BGC0000504	0.27	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500	0.27	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000499	0.74	RiPP	butyrivibriocin OR79	Butyrivibrio fibrisolvens
BGC0000562	0.70	RiPP	variacin	Kocuria varians
BGC0000521	0.69	RiPP	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000626	0.69	RiPP	thuricin	Bacillus thuringiensis
BGC0000532	0.66	RiPP	mutacin II	Streptococcus mutans
BGC0000539	0.65	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0002630	0.65	RiPP	thatisin	Lysobacter antibioticus
BGC0001787	0.63	RiPP	suicin 3908	Streptococcus suis
BGC0000504	0.61	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500	0.60	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum

Similar known gene clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for lctM

lctA

Leader:

MKEQNSFNLLQEVTESELDLILGA

Core:

KGGSGVIHTISHECNMNSWQFVFTCCS

Core with dehydrations:

KGGDhaGVIHDhbIDhaHECysNMNDhaWQFVFDhbCysCysDha

antiSMASH-DB 4.0 matches for lctA

100.0% NZ_CP069183.1: Lanthipeptides: LLNCDO700_RS13730_lanthipeptide

KGGSGVIHTISHECNMNSWQFVFTCCS

77.8% NZ_JAHBEV010000004.1and 3 others:

NZ_JAHBEX010000010.1 Lanthipeptides: KII86_RS06785_lanthipeptideNZ_JAHBFD010000039.1 Lanthipeptides: KIJ16_RS07340_lanthipeptideNZ_LN890331.1 Lanthipeptides: LEKG_RS02295_lanthipeptide

Lanthipeptides: KII98_RS01100_lanthipeptide

SGVIHTISHECNMNSWQFVFTCCS

SGVI+T+SHECNMNSWQFVFTCC+

SGVINTVSHECNMNSWQFVFTCCA

77.8% NZ_JH792236.1and 1 other:

NZ_JH792236.1 Lanthipeptides: IIM_RS26240_lanthipeptide

Lanthipeptides: IIM_RS26245_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCCS

GSGVI TISHEC+MNSWQ +FTCCS

GSGVIKTISHECHMNSWQAIFTCCS

with 71 more sequence matches

77.8% NZ_VDNV01000006.1: Lanthipeptides: FSV44_RS08765_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCCS

G GVI TISHEC MNSWQF+FTCCS

GGGVIQTISHECRMNSWQFLFTCCS

74.1% NC_012470.1and 2 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06490_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09840_lanthipeptide

Lanthipeptides: SZO_RS04065_lanthipeptide

GGSGVIHTISHECNMNSWQFVFTCCS

G +G I TISHEC+MNSWQF+FTCCS

GKNGAIKTISHECHMNSWQFLFTCCS

74.1% NC_012470.1and 11 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06485_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05185_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05180_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09835_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09830_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05350_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05345_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05065_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05060_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05580_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05575_lanthipeptide

Lanthipeptides: SZO_RS04070_lanthipeptide

GGSGVIHTISHECNMNSWQFVFTCCS

G +GV TISHEC+MNSWQF+FTCCS

GKNGVFKTISHECHMNSWQFLFTCCS

74.1% NZ_CP026729.1: Lanthipeptides: BKKJ1_RS07010_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCC

G+GV+ TISHECNMNSWQF+FTCC

GNGVVTTISHECNMNSWQFLFTCC

74.1% NZ_CP046629.1and 3 others:

NZ_FNJX01000002.1 Lanthipeptides: BLR40_RS05025_lanthipeptideNZ_FNZS01000001.1 Lanthipeptides: BMX70_RS03125_lanthipeptideNZ_FOLK01000002.1 Lanthipeptides: BM262_RS05670_lanthipeptide

Lanthipeptides: GPA00_RS05740_lanthipeptide

KGGSGVIHTISHECNMNSWQFVFTCCS

K GSGV+ T+SH+C+MNSWQF+FTCCS

KKGSGVVPTVSHDCHMNSWQFLFTCCS

74.1% NZ_CP051645.1and 2 others:

NZ_JAKVFF010000018.1 Lanthipeptides: MKR34_RS11425_lanthipeptideNZ_VDOJ01000018.1 Lanthipeptides: FSV48_RS11975_lanthipeptide

Lanthipeptides: HHJ99_RS13350_lanthipeptide

KGGSGVIHTISHECNMNSWQFVFTCCS

K SGVI T+SH+C+MNS+QFVFTCCS

KKKSGVIPTVSHDCHMNSFQFVFTCCS

74.1% NZ_JAEEGA010000010.1: Lanthipeptides: I6N95_RS15660_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCCS

G+GVI TISHEC+MNSWQ++FTCCS

GNGVIKTISHECHMNSWQWIFTCCS

74.1% NZ_LT732526.1and 1 other:

NZ_LT732526.1 Lanthipeptides: BQ9856_RS23075_lanthipeptide

Lanthipeptides: BQ9856_RS23080_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCCS

G+GVI TISHEC MN+WQF+FTCCS

GNGVIKTISHECAMNTWQFIFTCCS

74.1% NZ_MSRJ01000005.1: Lanthipeptides: BKH06_RS03755_lanthipeptide

GVIHTISHECNMNSWQFVFTCCS

GV+ TISHECNMNSWQF+FTCCS

GVVTTISHECNMNSWQFIFTCCS

70.4% NZ_CP023483.1: Lanthipeptides: CNY62_RS11970_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCCS

G+G I TISHEC+MN+WQF+FTCCS

GNGAIRTISHECHMNTWQFLFTCCS

70.4% NZ_CP084014.1and 6 others:

NZ_CP084014.1 Lanthipeptides: LCQ72_RS00100_lanthipeptideNZ_CP084014.1 Lanthipeptides: LCQ72_RS00095_lanthipeptideNZ_CP094679.1 Lanthipeptides: K5I24_RS13105_lanthipeptideNZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12415_lanthipeptideNZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12410_lanthipeptideNZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12405_lanthipeptide

Lanthipeptides: LCQ72_RS00105_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCC

G+GV+ TISHECNMN+WQF+FTCC

GNGVLKTISHECNMNTWQFLFTCC

70.4% NZ_GL882519.1: Lanthipeptides: HMPREF9056_RS03330_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCCS

G+GV +T+SHEC+MNSWQF+FTCCS

GNGVYYTLSHECHMNSWQFIFTCCS

70.4% NZ_NWMU01000024.1and 3 others:

NZ_NWMU01000024.1 Lanthipeptides: CO197_RS09145_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01575_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01570_lanthipeptide

Lanthipeptides: CO197_RS09150_lanthipeptide

GGSGVIHTISHECNMNSWQFVFTCCS

G +GV TISHEC+MNS+QF FTCCS

GKNGVFKTISHECHMNSFQFFFTCCS

70.4% NZ_QTVL01000002.1and 5 others:

NZ_QTVL01000002.1 Lanthipeptides: DWZ44_RS04150_lanthipeptideNZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14340_lanthipeptideNZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14335_lanthipeptideNZ_QUKU01000003.1 Lanthipeptides: DXC27_RS02940_lanthipeptideNZ_QUKU01000003.1 Lanthipeptides: DXC27_RS02935_lanthipeptide

Lanthipeptides: DWZ44_RS04155_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCC

G GV TISHECNMN+WQF+FTCC

GDGVFRTISHECNMNTWQFIFTCC

66.7% NZ_CP046304.1: Lanthipeptides: FOC54_RS00030_lanthipeptide

KGGSGVIHTISHECNMNSWQFVFTCCS

K SGVI T+SH+C+MN++QF+FTCCS

KKKSGVIPTVSHDCHMNTFQFMFTCCS

66.7% NZ_FOZB01000002.1: Lanthipeptides: BM306_RS07850_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCCS

G GV TISHEC+MN+W F+FTCCS

GDGVFRTISHECHMNTWMFIFTCCS

66.7% NZ_GL985606.1: Lanthipeptides: HMPREF9062_RS00700_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCC

G+GV HTISHEC NSW F+FTCC

GNGVFHTISHECYYNSWAFIFTCC

63.0% NZ_AP025017.1: Lanthipeptides: MANAM107_RS05920_lanthipeptide

SGVIHTISHECNMNSWQFVFTCCS

+GVI TISHEC++N+W F FTCCS

NGVITTISHECHLNTWAFAFTCCS

59.3% NC_013928.1and 8 others:

NC_013928.1 Lanthipeptides: SMUNN2025_RS01700_lanthipeptideNZ_CP023477.1 Lanthipeptides: CO204_RS01885_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01090_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01080_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01745_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01735_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07575_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07565_lanthipeptide

Lanthipeptides: SMUNN2025_RS01710_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCCS

G G + TISHEC NSW F+ TCCS

GKGAVGTISHECRYNSWAFLATCCS

59.3% NZ_ALSD01000046.1and 49 others:

NZ_CAAHGW010000010.1 Lanthipeptides: E9435_RS08890_lanthipeptideNZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS02935_lanthipeptideNZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08685_lanthipeptideNZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08680_lanthipeptideNZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05700_lanthipeptideNZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08730_lanthipeptideNZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08725_lanthipeptideNZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08980_lanthipeptideNZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08975_lanthipeptideNZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01070_lanthipeptideNZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09265_lanthipeptideNZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09260_lanthipeptideNZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08765_lanthipeptideNZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08760_lanthipeptideNZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08915_lanthipeptideNZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08910_lanthipeptideNZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02170_lanthipeptideNZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09655_lanthipeptideNZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03455_lanthipeptideNZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03450_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08825_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08820_lanthipeptideNZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03170_lanthipeptideNZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02470_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08470_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08465_lanthipeptideNZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09580_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09035_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09030_lanthipeptideNZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08495_lanthipeptideNZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08490_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08505_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08500_lanthipeptideNZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06790_lanthipeptideNZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06785_lanthipeptideNZ_CM001076.1 Lanthipeptides: SDD27957_RS04310_lanthipeptideNZ_CM001076.1 Lanthipeptides: SDD27957_RS04305_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02595_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02590_lanthipeptideNZ_CP035428.1 Lanthipeptides: ETT71_RS02815_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06680_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06675_lanthipeptideNZ_CP035443.1 Lanthipeptides: ETT56_RS07265_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS105315_lanthipeptideNZ_LR793258.1 Lanthipeptides: HV369_RS03145_lanthipeptideNZ_LR793258.1 Lanthipeptides: HV369_RS03140_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06755_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06750_lanthipeptideNZ_LT545678.1 Lanthipeptides: BJR96_RS07040_lanthipeptide

Lanthipeptides: SAG0161_RS120605_lanthipeptide

GGSGVIHTISHECNMNSWQFVFTCCS

G +GV TISHEC++N+W F+ TCCS

GKNGVFKTISHECHLNTWAFLATCCS

59.3% NZ_CAAHHE010000002.1and 13 others:

NZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08675_lanthipeptideNZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05705_lanthipeptideNZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08735_lanthipeptideNZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08985_lanthipeptideNZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01075_lanthipeptideNZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09255_lanthipeptideNZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08920_lanthipeptideNZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09650_lanthipeptideNZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03445_lanthipeptideNZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03175_lanthipeptideNZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02475_lanthipeptideNZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09585_lanthipeptideNZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08485_lanthipeptide

Lanthipeptides: E9499_RS02930_lanthipeptide

GGSGVIHTISHECNMNSWQFVFTCC

GG GV +TIS EC NS Q +FTCC

GGHGV-NTISAECRWNSLQAIFTCC

59.3% NZ_CP018188.1and 17 others:

NZ_CP018188.1 Lanthipeptides: BSR19_RS11175_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07300_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07295_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09705_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09700_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09300_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09295_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09300_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09295_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06585_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06580_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06585_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06580_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05120_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05115_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04335_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04330_lanthipeptide

Lanthipeptides: BSR19_RS11180_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCCS

G+GV TISHEC++N+W F+ TCCS

GNGVFKTISHECHLNTWAFLATCCS

59.3% NZ_CP023477.1: Lanthipeptides: CO204_RS01875_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCCS

G G + TISHEC NSW F+ TCCS

GKGTVGTISHECRYNSWAFLATCCS

59.3% NZ_CP031746.1: Lanthipeptides: DCC27_RS08165_lanthipeptide

SGVIHTISHECNMNSWQFVFTCCS

GVI T++HEC+MNSWQ + TCCS

DGVISTLTHECHMNSWQGLLTCCS

59.3% NZ_CP044492.1and 1 other:

NZ_CP066294.2 Lanthipeptides: IGS65_RS08185_lanthipeptide

Lanthipeptides: FSA31_RS00605_lanthipeptide

KGGSGVIHTISHECNMNSWQFVFTCC

+ GV+ T+S+EC MNSWQ VFTCC

RWWQGVVPTVSYECRMNSWQHVFTCC

59.3% NZ_CP046956.1: Lanthipeptides: ERJ70_RS03695_lanthipeptide

SGVIHTISHECNMNSWQFVFTCC

G I T+SHEC+MN+WQF+FTCC

DGAISTVSHECHMNTWQFIFTCC

59.3% NZ_CP083176.1and 4 others:

NZ_JABUHD010000002.1 Lanthipeptides: HRR08_RS05415_lanthipeptideNZ_LSLF01000001.1 Lanthipeptides: AXE72_RS04025_lanthipeptideNZ_PNHB01000001.1 Lanthipeptides: CJ210_RS02800_lanthipeptideNZ_QJVA01000001.1 Lanthipeptides: D0T19_RS02755_lanthipeptide

Lanthipeptides: K9E37_RS06280_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCC

G GV+HT++HEC+MN+WQF+ TCC

GDGVMHTLTHECHMNTWQFLLTCC

59.3% NZ_MSRU01000008.1: Lanthipeptides: BKH03_RS04355_lanthipeptide

GGSGVIHTISHECNMNSWQFVFTCCS

GG GV +I+HEC MNS Q + TCCS

GGDGVKWSITHECYMNSLQVLLTCCS

59.3% NZ_WBPF01000002.1: Lanthipeptides: F8162_RS00195_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCCS

G TISHEC+ N+WQF+FTCCS

DKGQFDTISHECHWNTWQFLFTCCS

55.6% NZ_CAAHKQ010000003.1: Lanthipeptides: E9664_RS02165_lanthipeptide

GGSGVIHTISHECNMNSWQFVFTCCS

G +GV TISHEC++N+W F+ CCS

GKNGVFKTISHECHLNTWAFLAICCS

55.6% NZ_CP037940.1: Lanthipeptides: EQG49_RS07315_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCC

GSGVI T++HEC MN++Q + TCC

GSGVIKTLTHECKMNTYQAILTCC

55.6% NZ_CP049223.1and 4 others:

NZ_CP049225.1 Lanthipeptides: G6Z85_RS06555_lanthipeptideNZ_CP049228.1 Lanthipeptides: G6Z83_RS06555_lanthipeptideNZ_JAKWZB010000003.1 Lanthipeptides: MMO78_RS01405_lanthipeptideNZ_PNGO01000002.1 Lanthipeptides: CJ224_RS02730_lanthipeptide

Lanthipeptides: G6Z86_RS06445_lanthipeptide

KGGSGVIHTISHECNMNSWQFVFTCC

+ GV+ T+SHEC MNS+Q +FTCC

RWWQGVLPTVSHECRMNSFQHIFTCC

55.6% NZ_CP060646.1: Lanthipeptides: H7789_RS06845_lanthipeptide

GGSGVIHTISHECNMNSWQFVFTCCS

G +GV TISHEC++N+W + TCCS

GKNGVFKTISHECHLNTWASLATCCS

55.6% NZ_CP072384.1: Lanthipeptides: J5A65_RS01395_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCC

G GV+ T++HEC+MNSWQ+ F CC

GRGVVPTVTHECHMNSWQWFFGCC

55.6% NZ_FNUH01000004.1and 1 other:

NZ_FOGM01000011.1 Lanthipeptides: BMX20_RS07220_lanthipeptide

Lanthipeptides: BLU50_RS05815_lanthipeptide

GVIHTISHECNMNSWQFVFTCC

GV+ T+S+EC MNSWQ +FTCC

GVVPTVSYECRMNSWQSIFTCC

55.6% NZ_MSRJ01000005.1: Lanthipeptides: BKH06_RS03750_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCCS

G+GV +T +HECN NS+ FTCCS

GNGVFYTFTHECNTNSFYVAFTCCS

48.1% NC_013928.1and 4 others:

NZ_CP023477.1 Lanthipeptides: CO204_RS01880_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01085_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01740_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07570_lanthipeptide

Lanthipeptides: SMUNN2025_RS01705_lanthipeptide

GGSGVIHTISHECNM-NSWQFVFTC

G+GVI TI+ C M N+ Q +FTC

AGNGVIRTITQGCRMPNNMQVLFTC

44.4% NC_012470.1and 28 others:

NZ_CAAHGW010000010.1 Lanthipeptides: E9435_RS08895_lanthipeptideNZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08770_lanthipeptideNZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02160_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08815_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08475_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09025_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08495_lanthipeptideNZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS10120_lanthipeptideNZ_CP018188.1 Lanthipeptides: BSR19_RS11185_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05190_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02600_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06670_lanthipeptideNZ_CP035443.1 Lanthipeptides: ETT56_RS07260_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07305_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09825_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05340_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09695_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS10860_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05070_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06745_lanthipeptideNZ_NWMU01000024.1 Lanthipeptides: CO197_RS09155_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04325_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01580_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05570_lanthipeptide

Lanthipeptides: SZO_RS10260_lanthipeptide

IHTISHECNMNSWQFVFTCC

++TIS EC NS Q +FTCC

VNTISAECRWNSLQAIFTCC

44.4% NZ_LR134406.1: Lanthipeptides: EL272_RS00695_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCC

G G I + +HECN N+ +FTCC

GWGSIFSFTHECNTNTMTQLFTCC

40.7% NC_013928.1and 4 others:

NZ_CP023477.1 Lanthipeptides: CO204_RS01890_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01095_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01750_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07560_lanthipeptide

Lanthipeptides: SMUNN2025_RS09965_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCC

G +TIS +C NS Q +F+CC

GGRASNTISSDCRWNSLQAIFSCC

40.7% NC_015760.1and 5 others:

NZ_CAJHJN010000010.1 Lanthipeptides: JMZ68_RS09030_lanthipeptideNZ_JACLQK010000036.1 Lanthipeptides: H7U04_RS11500_lanthipeptideNZ_JADPEB010000003.1 Lanthipeptides: I4U26_RS02800_lanthipeptideNZ_JAQCST010000021.1 Lanthipeptides: PGZ09_RS09470_lanthipeptideNZ_OU540596.1 Lanthipeptides: JQ838_RS05640_lanthipeptide

Lanthipeptides: SALIVB_RS03310_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCC

G+GV+ T++HECN+ +W CC

GNGVVLTLTHECNLATWTKKLKCC

40.7% NZ_ALSD01000046.1and 5 others:

NZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06795_lanthipeptideNZ_CM001076.1 Lanthipeptides: SDD27957_RS10995_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS1000000113590_lanthipeptideNZ_LR793258.1 Lanthipeptides: HV369_RS03150_lanthipeptideNZ_LT545678.1 Lanthipeptides: BJR96_RS11590_lanthipeptide

Lanthipeptides: SAG0161_RS1000000124770_lanthipeptide

IHTISHECNMNSWQFVFTCC

++TIS EC NS Q +F+CC

VNTISAECRWNSLQAIFSCC

40.7% NZ_CP022413.2and 1 other:

NZ_JAQEYW010000009.1 Lanthipeptides: PG422_RS09400_lanthipeptide

Lanthipeptides: CGC63_RS01420_lanthipeptide

SGVIHTISHECNMNSWQFVFTCC

SGV+ TIS EC F CC

SGVVCTISVECG---SIFTLACC

37.0% NZ_CP045267.1and 1 other:

NZ_CP045267.1 Lanthipeptides: FDZ14_RS00155_lanthipeptide

Lanthipeptides: FDZ14_RS00155_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCC

G GV+ T + EC + + F F CC

GDGVVKTATSECYLGT--FAFACC

37.0% NZ_CP077726.1and 12 others:

NZ_CP077726.1 Lanthipeptides: KTC92_RS18420_lanthipeptideNZ_CP077726.1 Lanthipeptides: KTC92_RS18415_lanthipeptideNZ_CP077726.1 Lanthipeptides: KTC92_RS18410_lanthipeptideNZ_CP077726.1 Lanthipeptides: KTC92_RS18405_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19070_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19065_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19060_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19055_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19050_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19045_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19040_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19035_lanthipeptide

Lanthipeptides: KTC92_RS18425_lanthipeptide

GSGVIHTISHECNMNS

G+GVI T +HEC NS

GNGVITTFTHECYYNS

37.0% NZ_CP086142.1and 3 others:

NZ_CP086142.1 Lanthipeptides: LL065_RS25460_lanthipeptideNZ_CP086142.1 Lanthipeptides: LL065_RS25455_lanthipeptideNZ_CP086142.1 Lanthipeptides: LL065_RS25450_lanthipeptide

Lanthipeptides: LL065_RS25465_lanthipeptide

GSGVIHTISHECNMNS

G GVI T +HEC NS

GGGVITTFTHECYYNS

37.0% NZ_JAFCGV010000005.1: Lanthipeptides: JQI09_RS04275_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCC

G GV+ T + EC + ++ FV CC

GDGVVKTATSECYLGTFAFV--CC

35.5% NZ_CP034248.1: Lanthipeptides: EIM92_RS14995_lanthipeptide

GVIHTISHECNMNS

GVI TISHEC+ NS

GVICTISHECHYNS

34.4% NZ_JAQDBP010000004.1and 18 others:

NZ_JAQDBP010000004.1 Lanthipeptides: PGY07_RS07085_lanthipeptideNZ_JAQEAL010000002.1 Lanthipeptides: PGU65_RS02165_lanthipeptideNZ_JAQESL010000010.1 Lanthipeptides: PG840_RS09145_lanthipeptideNZ_JAQEUC010000007.1 Lanthipeptides: PG788_RS06860_lanthipeptideNZ_QRHW01000005.1 Lanthipeptides: DW641_RS05035_lanthipeptideNZ_QROS01000011.1 Lanthipeptides: DW021_RS13630_lanthipeptideNZ_QRPQ01000001.1 Lanthipeptides: DWZ74_RS02490_lanthipeptideNZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptideNZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptideNZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptideNZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptideNZ_QTZB01000014.1 Lanthipeptides: DXC15_RS13895_lanthipeptideNZ_QUCI01000011.1 Lanthipeptides: DW648_RS10830_lanthipeptideNZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptideNZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptideNZ_QUKU01000006.1 Lanthipeptides: DXC27_RS05470_lanthipeptide

Lanthipeptides: PGY07_RS07085_lanthipeptide

GGSGVIHTISHECNMNSWQFVFTCC

SGV+ TIS EC F CC

ASSGVVCTISVECG---SIFTLACC

33.3% NZ_CP071875.1: Lanthipeptides: J4I02_RS02880_lanthipeptide

GVIHTISHECNMNSWQFVFTCC

G I T++HEC W ++CC

GAICTLTHECAGTHW---YSCC

33.3% NZ_CP117876.1: Lanthipeptides: PQ460_RS01735_lanthipeptide

GSGVIHTISHECNMNSWQFVFTCC

G GV+ T + EC + + F+ CC

GDGVVKTATSECYLGTVAFI--CC

29.6% NC_016582.1and 1 other:

NC_016582.1 Lanthipeptides: SBI_RS34375_lanthipeptide

Lanthipeptides: SBI_RS34375_lanthipeptide

GGSGVIHTISHECNMN

GG G+ T+S EC N

GGFGLFCTLSKECQPN

29.4% NZ_FMVM01000006.1and 2 others:

NZ_RIAS01000010.1 Lanthipeptides: EC604_RS18225_lanthipeptideNZ_VEJI01000010.1 Lanthipeptides: FS576_RS22075_lanthipeptide

Lanthipeptides: BLQ13_RS10365_lanthipeptide

KGGSGVIHTISHECNMNS

K GV T+SHEC+ NS

KKSGGVFCTVSHECHYNS

29.0% NZ_FNDV01000004.1: Lanthipeptides: BLR56_RS33870_lanthipeptide

GGSGVIHTISHECNMNSWQFVFTCCS

G SG+ N+ SW TCC

GFSGIFD---DPANLASWPTSTTCCP

26.7% NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS02100_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06725_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06725_lanthipeptide

Lanthipeptides: BKP57_RS02100_lanthipeptide

GGSGVIHTISHEC

G G I T SHEC

GNDGKICTFSHEC

26.7% NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide

Lanthipeptides: EI692_RS18440_lanthipeptide

GGSGVIHTISHEC

G G TISHEC

GNKGGWCTISHEC

26.7% NZ_FNHR01000005.1and 1 other:

NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05590_lanthipeptide

Lanthipeptides: BLQ37_RS05590_lanthipeptide

GGSGVIHTISHEC

G +G TISHEC

GNNGNWCTISHEC

26.5% NZ_CAKMMP010000011.1: Lanthipeptides: L6H98_RS19925_lanthipeptide

GVIHTISHECNMNS

GV T+SHEC+ NS

GVFCTVSHECHYNS

26.5% NZ_CP018620.1and 1 other:

NZ_CP062165.1 Lanthipeptides: JNUCC31_RS16755_lanthipeptide

Lanthipeptides: BS614_RS05680_lanthipeptide

KGGSGVIHTISHECNMNS

+ GV T+SHEC+ NS

QASGGVFCTVSHECHYNS

25.8% NZ_CP095046.1: Lanthipeptides: MUN79_RS04140_lanthipeptide

GSGVIHTISHECN

G G+ TIS ECN

GPGMFLTISGECN

24.2% NZ_AP024169.1: Lanthipeptides: bsdtb5_RS06105_lanthipeptide

GGSGVIHTISHECNMN

G G + TIS+EC N

GKCGRMPTISYECTSN

23.3% NZ_CACZYW010000004.1and 1 other:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide

Lanthipeptides: HUF10_RS02825_lanthipeptide

GGSGVIHTISHEC

G +G T+SHEC

GNNGNWCTLSHEC

23.3% NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide

Lanthipeptides: HGK68_RS15125_lanthipeptide

GGSGVIHTISHEC

G +G + TI+HEC

GNNGWLCTITHEC

22.6% NZ_CP102975.1and 1 other:

NZ_FMOE01000002.1 Lanthipeptides: BJT27_RS07805_lanthipeptide

Lanthipeptides: NW953_RS00170_lanthipeptide

GGSGVIHTISHEC

G +G + T+SHEC

GNNGKLCTVSHEC

22.2% NZ_AP018365.1: Lanthipeptides: RVR_RS00125_lanthipeptide

SWQFVFTCC

SWQ F+CC

SWQGSFSCC

22.2% NZ_FONG01000023.1and 4 others:

NZ_FONG01000023.1 Lanthipeptides: BM076_RS29665_lanthipeptideNZ_FONG01000023.1 Lanthipeptides: BM076_RS29665_lanthipeptideNZ_FONG01000023.1 Lanthipeptides: BM076_RS29665_lanthipeptideNZ_FONG01000023.1 Lanthipeptides: BM076_RS29665_lanthipeptide

Lanthipeptides: BM076_RS29665_lanthipeptide

SWQFVFTCC

SWQ+ F+CC

SWQWSFSCC

18.5% NZ_AP018365.1: Lanthipeptides: RVR_RS00130_lanthipeptide

MNSWQFVFTCCS

+ SW+ F+CC

IGSWEGTFSCCD

18.2% NZ_AP024169.1: Lanthipeptides: bsdtb5_RS06100_lanthipeptide

GGSGVIHTISHECNMN

G G + T+S+EC+ +

GRCGAVPTLSYECSSD

15.7% NZ_CP040417.1and 2 others:

NZ_CP040938.1 Lanthipeptides: B5772_RS02450_lanthipeptideNZ_CP040938.1 Lanthipeptides: B5772_RS02450_lanthipeptide

Lanthipeptides: FE328_RS05345_lanthipeptide

GGSGVIHTISHEC

G G I T SHEC

GNDGKICTYSHEC

12.0% NZ_MIYS01000053.1: Lanthipeptides: allorf_00387_00584_lanthipeptide

KGGSGVIHTISH

+GG V+H I H

RGGISVVHQIQH

11.4% NZ_CP077658.1: Lanthipeptides: allorf_7489210_7489407_lanthipeptide

NSWQFVFTCC

SW FV++ C

RSWSFVYSAC

MIBiG 3.1 matches for lctA

12.8% BGC0001229 (SBI_06990): Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

TISHECNMN

T+S EC N

TLSKECQPN

AAC72262.1

Leader:

MKLENLFIEKLHGIYNYDVDFNEDITFLYG

Core:

SNGCG

Core with dehydrations:

DhaNGCysG

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

lctA - Class II

Cleavage pHMM score: 1.80

RODEO score: 0

Monoisotopic mass: 2863.3 Da

Molecular weight: 2865.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2883.2 Da N = 1; 2901.3 Da N = 2; 2919.3 Da N = 3

AAC72262.1 - Class II

Cleavage pHMM score: -4.60

RODEO score: 0

Monoisotopic mass: 418.1 Da

Molecular weight: 418.4 Da

Number of bridges: 1