Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000526.1:
Cluster 1RiPP115171

BGC0000526, macedocin biosynthetic gene cluster from Streptococcus macedonicus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: macedocin
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Lantipeptide (linear)

Gene cluster description

macedocin (BGC0000526). Gene Cluster 1. Biosynthetic class = RiPP. GenBank DQ835394. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Detailed annotation

mcdA leader / core peptide, putative Class II
MEKETTIIESIQEVSLEELDQIIGA - GKNGVFKDhbIDhaHECHLNDhbWAFLADhbCCDha
mcdA_ leader / core peptide, putative Class II
MEKETTIIESIQEVSLEELDQIIGA - GKNGVFKDhbIDhaHECHLNDhbWAFLADhbCCDha
mcdA1 leader / core peptide, putative Class II
MKNNNKICQDALESLQELKLEEVDELLGG - AGHGVNDhbIDhaAECRWNDhaLQAIFDhaCC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Enzymatic assays, Gene expression correlated with compound production, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Konstantinos Papadimitriou (Agricultural University of Athens)

Literature references

1. Georgalaki MD et al. (2002) Macedocin, a food-grade lantibiotic produced by Streptococcus macedonicus ACA-DC 198. Appl Environ Microbiol 68(12):5891-903.
2. Papadelli M et al. (2007) Characterization of the gene cluster involved in the biosynthesis of macedocin, the lantibiotic produced by Streptococcus macedonicus. FEMS Microbiol Lett 272(1):75-82. doi:
3. Georgalaki M et al. (2010) Milk protein fragments induce the biosynthesis of macedocin, the lantibiotic produced by Streptococcus macedonicus ACA-DC 198. Appl Environ Microbiol 76(4):1143-51. doi: 10.1128/AEM.00151-09. Epub