BGC0000532 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000532 (Streptococcus mutans)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-ii	1	3,480	mutacin II	ribosomal:RiPP:Lanthipeptide	100%

BGC0000532 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 3,480 nt. (total: 3,480 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 3,481
Label		BGC0000532

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000532	1.00	RiPP	mutacin II	Streptococcus mutans
BGC0000562	0.34	RiPP	variacin	Kocuria varians
BGC0000539	0.25	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000521	0.21	RiPP	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000547	0.18	RiPP	salivaricin 9	Streptococcus salivarius
BGC0000557	0.14	RiPP	streptococcin A-FF22	Streptococcus pyogenes
BGC0001407	0.12	RiPP	bicereucin	Bacillus cereus SJ1
BGC0001788	0.12	RiPP	suicin 65	Streptococcus suis
BGC0000526	0.12	RiPP	macedocin	Streptococcus macedonicus
BGC0000550	0.12	RiPP	salivaricin G32	Streptococcus salivarius

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000532	1.00	RiPP	mutacin II	Streptococcus mutans
BGC0000562	0.67	RiPP	variacin	Kocuria varians
BGC0000539	0.59	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000521	0.54	RiPP	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000547	0.49	RiPP	salivaricin 9	Streptococcus salivarius
BGC0000557	0.43	RiPP	streptococcin A-FF22	Streptococcus pyogenes
BGC0001407	0.41	RiPP	bicereucin	Bacillus cereus SJ1
BGC0001788	0.40	RiPP	suicin 65	Streptococcus suis
BGC0000526	0.40	RiPP	macedocin	Streptococcus macedonicus
BGC0000550	0.39	RiPP	salivaricin G32	Streptococcus salivarius

Similar known gene clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for mutM

mutA

Leader:

MNKLNSNAVVSLNEVSDSELDTILGG

Core:

NRWWQGVVPTVSYECRMNSWQHVFTCC

Core with dehydrations:

NRWWQGVVPDhbVDhaYECysRMNDhaWQHVFDhbCysCys

antiSMASH-DB 4.0 matches for mutA

100.0% NZ_CP044492.1and 1 other:

NZ_CP066294.2 Lanthipeptides: IGS65_RS08185_lanthipeptide

Lanthipeptides: FSA31_RS00605_lanthipeptide

NRWWQGVVPTVSYECRMNSWQHVFTCC

85.2% NZ_FNUH01000004.1and 1 other:

NZ_FOGM01000011.1 Lanthipeptides: BMX20_RS07220_lanthipeptide

Lanthipeptides: BLU50_RS05815_lanthipeptide

NRWWQGVVPTVSYECRMNSWQHVFTCC

+R+WQGVVPTVSYECRMNSWQ +FTCC

SRFWQGVVPTVSYECRMNSWQSIFTCC

81.5% NZ_CP049223.1and 4 others:

NZ_CP049225.1 Lanthipeptides: G6Z85_RS06555_lanthipeptideNZ_CP049228.1 Lanthipeptides: G6Z83_RS06555_lanthipeptideNZ_JAKWZB010000003.1 Lanthipeptides: MMO78_RS01405_lanthipeptideNZ_PNGO01000002.1 Lanthipeptides: CJ224_RS02730_lanthipeptide

Lanthipeptides: G6Z86_RS06445_lanthipeptide

NRWWQGVVPTVSYECRMNSWQHVFTCC

+RWWQGV+PTVS+ECRMNS+QH+FTCC

SRWWQGVLPTVSHECRMNSFQHIFTCC

with 62 more sequence matches

63.0% NZ_CP046629.1and 3 others:

NZ_FNJX01000002.1 Lanthipeptides: BLR40_RS05025_lanthipeptideNZ_FNZS01000001.1 Lanthipeptides: BMX70_RS03125_lanthipeptideNZ_FOLK01000002.1 Lanthipeptides: BM262_RS05670_lanthipeptide

Lanthipeptides: GPA00_RS05740_lanthipeptide

RWWQGVVPTVSYECRMNSWQHVFTCC

+ GVVPTVS++C MNSWQ +FTCC

KKGSGVVPTVSHDCHMNSWQFLFTCC

63.0% NZ_JAHBEV010000004.1and 3 others:

NZ_JAHBEX010000010.1 Lanthipeptides: KII86_RS06785_lanthipeptideNZ_JAHBFD010000039.1 Lanthipeptides: KIJ16_RS07340_lanthipeptideNZ_LN890331.1 Lanthipeptides: LEKG_RS02295_lanthipeptide

Lanthipeptides: KII98_RS01100_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GV+ TVS+EC MNSWQ VFTCC

SGVINTVSHECNMNSWQFVFTCC

59.3% NZ_CP026729.1: Lanthipeptides: BKKJ1_RS07010_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GVV T+S+EC MNSWQ +FTCC

NGVVTTISHECNMNSWQFLFTCC

59.3% NZ_CP051645.1and 2 others:

NZ_JAKVFF010000018.1 Lanthipeptides: MKR34_RS11425_lanthipeptideNZ_VDOJ01000018.1 Lanthipeptides: FSV48_RS11975_lanthipeptide

Lanthipeptides: HHJ99_RS13350_lanthipeptide

RWWQGVVPTVSYECRMNSWQHVFTCC

+ GV+PTVS++C MNS+Q VFTCC

KKKSGVIPTVSHDCHMNSFQFVFTCC

59.3% NZ_CP069183.1: Lanthipeptides: LLNCDO700_RS13730_lanthipeptide

RWWQGVVPTVSYECRMNSWQHVFTCC

+ GV+ T+S+EC MNSWQ VFTCC

KGGSGVIHTISHECNMNSWQFVFTCC

59.3% NZ_CP072384.1: Lanthipeptides: J5A65_RS01395_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

+GVVPTV++EC MNSWQ F CC

RGVVPTVTHECHMNSWQWFFGCC

59.3% NZ_MSRJ01000005.1: Lanthipeptides: BKH06_RS03755_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

+GVV T+S+EC MNSWQ +FTCC

EGVVTTISHECNMNSWQFIFTCC

59.3% NZ_VDNV01000006.1: Lanthipeptides: FSV44_RS08765_lanthipeptide

GVVPTVSYECRMNSWQHVFTCC

GV+ T+S+ECRMNSWQ +FTCC

GVIQTISHECRMNSWQFLFTCC

55.6% NC_012470.1and 11 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06485_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05185_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05180_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09835_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09830_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05350_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05345_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05065_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05060_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05580_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05575_lanthipeptide

Lanthipeptides: SZO_RS04070_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GV T+S+EC MNSWQ +FTCC

NGVFKTISHECHMNSWQFLFTCC

55.6% NZ_GL882519.1: Lanthipeptides: HMPREF9056_RS03330_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GV T+S+EC MNSWQ +FTCC

NGVYYTLSHECHMNSWQFIFTCC

55.6% NZ_JAEEGA010000010.1: Lanthipeptides: I6N95_RS15660_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GV+ T+S+EC MNSWQ +FTCC

NGVIKTISHECHMNSWQWIFTCC

55.6% NZ_JH792236.1and 1 other:

NZ_JH792236.1 Lanthipeptides: IIM_RS26240_lanthipeptide

Lanthipeptides: IIM_RS26245_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GV+ T+S+EC MNSWQ +FTCC

SGVIKTISHECHMNSWQAIFTCC

51.9% NC_012470.1and 2 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06490_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09840_lanthipeptide

Lanthipeptides: SZO_RS04065_lanthipeptide

GVVPTVSYECRMNSWQHVFTCC

G + T+S+EC MNSWQ +FTCC

GAIKTISHECHMNSWQFLFTCC

51.9% NZ_CP046304.1: Lanthipeptides: FOC54_RS00030_lanthipeptide

RWWQGVVPTVSYECRMNSWQHVFTCC

+ GV+PTVS++C MN++Q +FTCC

KKKSGVIPTVSHDCHMNTFQFMFTCC

51.9% NZ_CP046956.1: Lanthipeptides: ERJ70_RS03695_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

G + TVS+EC MN+WQ +FTCC

DGAISTVSHECHMNTWQFIFTCC

51.9% NZ_CP084014.1and 6 others:

NZ_CP084014.1 Lanthipeptides: LCQ72_RS00100_lanthipeptideNZ_CP084014.1 Lanthipeptides: LCQ72_RS00095_lanthipeptideNZ_CP094679.1 Lanthipeptides: K5I24_RS13105_lanthipeptideNZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12415_lanthipeptideNZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12410_lanthipeptideNZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12405_lanthipeptide

Lanthipeptides: LCQ72_RS00105_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GV+ T+S+EC MN+WQ +FTCC

NGVLKTISHECNMNTWQFLFTCC

51.9% NZ_LT732526.1and 1 other:

NZ_LT732526.1 Lanthipeptides: BQ9856_RS23075_lanthipeptide

Lanthipeptides: BQ9856_RS23080_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GV+ T+S+EC MN+WQ +FTCC

NGVIKTISHECAMNTWQFIFTCC

51.9% NZ_NWMU01000024.1and 3 others:

NZ_NWMU01000024.1 Lanthipeptides: CO197_RS09145_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01575_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01570_lanthipeptide

Lanthipeptides: CO197_RS09150_lanthipeptide

GVVPTVSYECRMNSWQHVFTCC

GV T+S+EC MNS+Q FTCC

GVFKTISHECHMNSFQFFFTCC

51.9% NZ_QTVL01000002.1and 5 others:

NZ_QTVL01000002.1 Lanthipeptides: DWZ44_RS04150_lanthipeptideNZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14340_lanthipeptideNZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14335_lanthipeptideNZ_QUKU01000003.1 Lanthipeptides: DXC27_RS02940_lanthipeptideNZ_QUKU01000003.1 Lanthipeptides: DXC27_RS02935_lanthipeptide

Lanthipeptides: DWZ44_RS04155_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GV T+S+EC MN+WQ +FTCC

DGVFRTISHECNMNTWQFIFTCC

48.1% NC_012470.1and 42 others:

NZ_CAAHGW010000010.1 Lanthipeptides: E9435_RS08895_lanthipeptideNZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS02930_lanthipeptideNZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08675_lanthipeptideNZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05705_lanthipeptideNZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08735_lanthipeptideNZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08985_lanthipeptideNZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01075_lanthipeptideNZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09255_lanthipeptideNZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08770_lanthipeptideNZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08920_lanthipeptideNZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02160_lanthipeptideNZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09650_lanthipeptideNZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03445_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08815_lanthipeptideNZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03175_lanthipeptideNZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02475_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08475_lanthipeptideNZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09585_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09025_lanthipeptideNZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08485_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08495_lanthipeptideNZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS10120_lanthipeptideNZ_CP018188.1 Lanthipeptides: BSR19_RS11185_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05190_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02600_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06670_lanthipeptideNZ_CP035443.1 Lanthipeptides: ETT56_RS07260_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07305_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09825_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05340_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09695_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS10860_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05070_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06745_lanthipeptideNZ_NWMU01000024.1 Lanthipeptides: CO197_RS09155_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04325_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01580_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05570_lanthipeptide

Lanthipeptides: SZO_RS10260_lanthipeptide

VPTVSYECRMNSWQHVFTCC

V T+S ECR NS Q +FTCC

VNTISAECRWNSLQAIFTCC

48.1% NC_013928.1and 8 others:

NC_013928.1 Lanthipeptides: SMUNN2025_RS01700_lanthipeptideNZ_CP023477.1 Lanthipeptides: CO204_RS01885_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01090_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01080_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01745_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01735_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07575_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07565_lanthipeptide

Lanthipeptides: SMUNN2025_RS01710_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

+G V T+S+ECR NSW + TCC

KGAVGTISHECRYNSWAFLATCC

48.1% NZ_CP023477.1: Lanthipeptides: CO204_RS01875_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

+G V T+S+ECR NSW + TCC

KGTVGTISHECRYNSWAFLATCC

48.1% NZ_CP023483.1: Lanthipeptides: CNY62_RS11970_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

G + T+S+EC MN+WQ +FTCC

NGAIRTISHECHMNTWQFLFTCC

48.1% NZ_CP031746.1: Lanthipeptides: DCC27_RS08165_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GV+ T+++EC MNSWQ + TCC

DGVISTLTHECHMNSWQGLLTCC

48.1% NZ_FOZB01000002.1: Lanthipeptides: BM306_RS07850_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GV T+S+EC MN+W +FTCC

DGVFRTISHECHMNTWMFIFTCC

48.1% NZ_GL985606.1: Lanthipeptides: HMPREF9062_RS00700_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GV T+S+EC NSW +FTCC

NGVFHTISHECYYNSWAFIFTCC

44.4% NZ_ALSD01000046.1and 5 others:

NZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06795_lanthipeptideNZ_CM001076.1 Lanthipeptides: SDD27957_RS10995_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS1000000113590_lanthipeptideNZ_LR793258.1 Lanthipeptides: HV369_RS03150_lanthipeptideNZ_LT545678.1 Lanthipeptides: BJR96_RS11590_lanthipeptide

Lanthipeptides: SAG0161_RS1000000124770_lanthipeptide

VPTVSYECRMNSWQHVFTCC

V T+S ECR NS Q +F+CC

VNTISAECRWNSLQAIFSCC

44.4% NZ_AP025017.1: Lanthipeptides: MANAM107_RS05920_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GV+ T+S+EC +N+W FTCC

NGVITTISHECHLNTWAFAFTCC

44.4% NZ_CP083176.1and 4 others:

NZ_JABUHD010000002.1 Lanthipeptides: HRR08_RS05415_lanthipeptideNZ_LSLF01000001.1 Lanthipeptides: AXE72_RS04025_lanthipeptideNZ_PNHB01000001.1 Lanthipeptides: CJ210_RS02800_lanthipeptideNZ_QJVA01000001.1 Lanthipeptides: D0T19_RS02755_lanthipeptide

Lanthipeptides: K9E37_RS06280_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GV+ T+++EC MN+WQ + TCC

DGVMHTLTHECHMNTWQFLLTCC

44.4% NZ_WBPF01000002.1: Lanthipeptides: F8162_RS00195_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

+G T+S+EC N+WQ +FTCC

KGQFDTISHECHWNTWQFLFTCC

40.7% NC_013928.1and 4 others:

NZ_CP023477.1 Lanthipeptides: CO204_RS01880_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01085_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01740_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07570_lanthipeptide

Lanthipeptides: SMUNN2025_RS01705_lanthipeptide

GVVPTVSYECRM-NSWQHVFTC

GV+ T++ CRM N+ Q +FTC

GVIRTITQGCRMPNNMQVLFTC

40.7% NZ_ALSD01000046.1and 67 others:

NZ_CAAHGW010000010.1 Lanthipeptides: E9435_RS08890_lanthipeptideNZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS02935_lanthipeptideNZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08685_lanthipeptideNZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08680_lanthipeptideNZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05700_lanthipeptideNZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08730_lanthipeptideNZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08725_lanthipeptideNZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08980_lanthipeptideNZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08975_lanthipeptideNZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01070_lanthipeptideNZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09265_lanthipeptideNZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09260_lanthipeptideNZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08765_lanthipeptideNZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08760_lanthipeptideNZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08915_lanthipeptideNZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08910_lanthipeptideNZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02170_lanthipeptideNZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09655_lanthipeptideNZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03455_lanthipeptideNZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03450_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08825_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08820_lanthipeptideNZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03170_lanthipeptideNZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02470_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08470_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08465_lanthipeptideNZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09580_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09035_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09030_lanthipeptideNZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08495_lanthipeptideNZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08490_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08505_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08500_lanthipeptideNZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06790_lanthipeptideNZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06785_lanthipeptideNZ_CM001076.1 Lanthipeptides: SDD27957_RS04310_lanthipeptideNZ_CM001076.1 Lanthipeptides: SDD27957_RS04305_lanthipeptideNZ_CP018188.1 Lanthipeptides: BSR19_RS11180_lanthipeptideNZ_CP018188.1 Lanthipeptides: BSR19_RS11175_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02595_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02590_lanthipeptideNZ_CP035428.1 Lanthipeptides: ETT71_RS02815_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06680_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06675_lanthipeptideNZ_CP035443.1 Lanthipeptides: ETT56_RS07265_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07300_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07295_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS105315_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09705_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09700_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09300_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09295_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09300_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09295_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06585_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06580_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06585_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06580_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05120_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05115_lanthipeptideNZ_LR793258.1 Lanthipeptides: HV369_RS03145_lanthipeptideNZ_LR793258.1 Lanthipeptides: HV369_RS03140_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06755_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06750_lanthipeptideNZ_LT545678.1 Lanthipeptides: BJR96_RS07040_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04335_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04330_lanthipeptide

Lanthipeptides: SAG0161_RS120605_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GV T+S+EC +N+W + TCC

NGVFKTISHECHLNTWAFLATCC

40.7% NZ_CP037940.1: Lanthipeptides: EQG49_RS07315_lanthipeptide

GVVPTVSYECRMNSWQHVFTCC

GV+ T+++EC+MN++Q + TCC

GVIKTLTHECKMNTYQAILTCC

40.7% NZ_CP060646.1: Lanthipeptides: H7789_RS06845_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GV T+S+EC +N+W + TCC

NGVFKTISHECHLNTWASLATCC

40.7% NZ_MSRJ01000005.1: Lanthipeptides: BKH06_RS03750_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GV T ++EC NS+ FTCC

NGVFYTFTHECNTNSFYVAFTCC

40.7% NZ_MSRU01000008.1: Lanthipeptides: BKH03_RS04355_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GV ++++EC MNS Q + TCC

DGVKWSITHECYMNSLQVLLTCC

37.0% NC_013928.1and 4 others:

NZ_CP023477.1 Lanthipeptides: CO204_RS01890_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01095_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01750_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07560_lanthipeptide

Lanthipeptides: SMUNN2025_RS09965_lanthipeptide

TVSYECRMNSWQHVFTCC

T+S +CR NS Q +F+CC

TISSDCRWNSLQAIFSCC

37.0% NZ_CAAHKQ010000003.1: Lanthipeptides: E9664_RS02165_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GV T+S+EC +N+W + CC

NGVFKTISHECHLNTWAFLAICC

35.3% NZ_CAKMMP010000011.1: Lanthipeptides: L6H98_RS19925_lanthipeptide

GVVPTVSYECRMNSWQHV--FTCC

GV TVS+EC NS TCC

GVFCTVSHECHYNSVSPSSWLTCC

35.3% NZ_FMVM01000006.1and 2 others:

NZ_RIAS01000010.1 Lanthipeptides: EC604_RS18225_lanthipeptideNZ_VEJI01000010.1 Lanthipeptides: FS576_RS22075_lanthipeptide

Lanthipeptides: BLQ13_RS10365_lanthipeptide

NRWWQGVVPTVSYECRMNSWQHV--FTCC

++ GV TVS+EC NS TCC

DKKSGGVFCTVSHECHYNSVSPSSWLTCC

33.3% NC_015760.1and 5 others:

NZ_CAJHJN010000010.1 Lanthipeptides: JMZ68_RS09030_lanthipeptideNZ_JACLQK010000036.1 Lanthipeptides: H7U04_RS11500_lanthipeptideNZ_JADPEB010000003.1 Lanthipeptides: I4U26_RS02800_lanthipeptideNZ_JAQCST010000021.1 Lanthipeptides: PGZ09_RS09470_lanthipeptideNZ_OU540596.1 Lanthipeptides: JQ838_RS05640_lanthipeptide

Lanthipeptides: SALIVB_RS03310_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GVV T+++EC + +W CC

NGVVLTLTHECNLATWTKKLKCC

33.3% NZ_CP045267.1and 1 other:

NZ_CP045267.1 Lanthipeptides: FDZ14_RS00155_lanthipeptide

Lanthipeptides: FDZ14_RS00155_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GVV T + EC + ++ F CC

DGVVKTATSECYLGTF--AFACC

33.3% NZ_CP117876.1: Lanthipeptides: PQ460_RS01735_lanthipeptide

WQGVVPTVSYECRMNSWQHVFTCC

GVV T + EC + + F CC

GDGVVKTATSECYLGTVA--FICC

33.3% NZ_JAFCGV010000005.1: Lanthipeptides: JQI09_RS04275_lanthipeptide

QGVVPTVSYECRMNSWQHVFTCC

GVV T + EC + ++ F CC

DGVVKTATSECYLGTFA--FVCC

29.6% NZ_LR134406.1: Lanthipeptides: EL272_RS00695_lanthipeptide

GVVPTVSYECRMNSWQHVFTCC

G + + ++EC N+ +FTCC

GSIFSFTHECNTNTMTQLFTCC

26.5% NZ_CP018620.1and 1 other:

NZ_CP062165.1 Lanthipeptides: JNUCC31_RS16755_lanthipeptide

Lanthipeptides: BS614_RS05680_lanthipeptide

GVVPTVSYECRMNS

GV TVS+EC NS

GVFCTVSHECHYNS

25.9% NZ_CP022413.2and 20 others:

NZ_JAQDBP010000004.1 Lanthipeptides: PGY07_RS07085_lanthipeptideNZ_JAQDBP010000004.1 Lanthipeptides: PGY07_RS07085_lanthipeptideNZ_JAQEAL010000002.1 Lanthipeptides: PGU65_RS02165_lanthipeptideNZ_JAQESL010000010.1 Lanthipeptides: PG840_RS09145_lanthipeptideNZ_JAQEUC010000007.1 Lanthipeptides: PG788_RS06860_lanthipeptideNZ_JAQEYW010000009.1 Lanthipeptides: PG422_RS09400_lanthipeptideNZ_QRHW01000005.1 Lanthipeptides: DW641_RS05035_lanthipeptideNZ_QROS01000011.1 Lanthipeptides: DW021_RS13630_lanthipeptideNZ_QRPQ01000001.1 Lanthipeptides: DWZ74_RS02490_lanthipeptideNZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptideNZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptideNZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptideNZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptideNZ_QTZB01000014.1 Lanthipeptides: DXC15_RS13895_lanthipeptideNZ_QUCI01000011.1 Lanthipeptides: DW648_RS10830_lanthipeptideNZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptideNZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptideNZ_QUKU01000006.1 Lanthipeptides: DXC27_RS05470_lanthipeptide

Lanthipeptides: CGC63_RS01420_lanthipeptide

QGVVPTVSYEC

GVV T+S EC

SGVVCTISVEC

25.9% NZ_CP077726.1and 12 others:

NZ_CP077726.1 Lanthipeptides: KTC92_RS18420_lanthipeptideNZ_CP077726.1 Lanthipeptides: KTC92_RS18415_lanthipeptideNZ_CP077726.1 Lanthipeptides: KTC92_RS18410_lanthipeptideNZ_CP077726.1 Lanthipeptides: KTC92_RS18405_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19070_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19065_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19060_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19055_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19050_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19045_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19040_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19035_lanthipeptide

Lanthipeptides: KTC92_RS18425_lanthipeptide

QGVVPTVSYECRMNS

GV+ T ++EC NS

NGVITTFTHECYYNS

25.9% NZ_CP086142.1and 3 others:

NZ_CP086142.1 Lanthipeptides: LL065_RS25460_lanthipeptideNZ_CP086142.1 Lanthipeptides: LL065_RS25455_lanthipeptideNZ_CP086142.1 Lanthipeptides: LL065_RS25450_lanthipeptide

Lanthipeptides: LL065_RS25465_lanthipeptide

GVVPTVSYECRMNS

GV+ T ++EC NS

GVITTFTHECYYNS

25.8% NZ_CP034248.1: Lanthipeptides: EIM92_RS14995_lanthipeptide

GVVPTVSYECRMNS

GV+ T+S+EC NS

GVICTISHECHYNS

24.2% NZ_AP024169.1: Lanthipeptides: bsdtb5_RS06100_lanthipeptide

GVVPTVSYEC

G VPT+SYEC

GAVPTLSYEC

24.2% NZ_AP024169.1: Lanthipeptides: bsdtb5_RS06110_lanthipeptide

GVVPTVSYECRMN

G PT+SYEC N

GGFPTISYECTSN

24.2% NZ_AP024169.1: Lanthipeptides: bsdtb5_RS06105_lanthipeptide

GVVPTVSYECRMN

G +PT+SYEC N

GRMPTISYECTSN

22.2% NC_011071.1and 41 others:

NZ_AP021867.1 Lassopeptides: GJU96_RS20605_lassopeptideNZ_CP011010.1 Lassopeptides: VN11_RS22530_lassopeptideNZ_CP011305.1 Lassopeptides: YH67_RS21020_lassopeptideNZ_CP015612.1 Lassopeptides: A7326_RS21600_lassopeptideNZ_CP027562.1 Lassopeptides: C6Y55_RS23185_lassopeptideNZ_CP029773.1 Lassopeptides: DM611_RS22725_lassopeptideNZ_CP031058.1 Lassopeptides: DUW70_RS11975_lassopeptideNZ_CP031167.1 Lassopeptides: MG068_RS21080_lassopeptideNZ_CP037858.1 Lassopeptides: EZ304_RS20935_lassopeptideNZ_CP040432.1 Lassopeptides: FEO95_RS22840_lassopeptideNZ_CP040438.1 Lassopeptides: FEO89_RS21625_lassopeptideNZ_CP040439.1 Lassopeptides: FEO88_RS23220_lassopeptideNZ_CP043578.1 Lassopeptides: F0Q13_RS11365_lassopeptideNZ_CP046588.1 Lassopeptides: GOC52_RS10870_lassopeptideNZ_CP047310.1 Lassopeptides: GS396_RS20180_lassopeptideNZ_CP060259.1 Lassopeptides: H7F32_RS11180_lassopeptideNZ_CP067993.1 Lassopeptides: JJL50_RS10815_lassopeptideNZ_CP077679.1 Lassopeptides: KS456_RS10490_lassopeptideNZ_CP080573.1 Lassopeptides: K1516_RS11235_lassopeptideNZ_CP090418.1 Lassopeptides: LYZ64_RS11980_lassopeptideNZ_CP096975.1 Lassopeptides: M1L61_RS12085_lassopeptideNZ_CP104169.1 Lassopeptides: NDR96_RS09175_lassopeptideNZ_CP106759.1 Lassopeptides: N8888_RS09665_lassopeptideNZ_CP120400.1 Lassopeptides: PVE91_RS09960_lassopeptideNZ_JABDRV010000002.1 Lassopeptides: HRL60_RS08285_lassopeptideNZ_JADCQA010000003.1 Lassopeptides: IMX13_RS03920_lassopeptideNZ_JAEDVS010000016.1 Lassopeptides: JAK50_RS09365_lassopeptideNZ_JAEDVW010000040.1 Lassopeptides: JAK53_RS10000_lassopeptideNZ_JAEDWA010000005.1 Lassopeptides: JAK63_RS01795_lassopeptideNZ_JAEDWK010000019.1 Lassopeptides: JAK51_RS11395_lassopeptideNZ_JAEDWU010000002.1 Lassopeptides: JAK37_RS06750_lassopeptideNZ_JAKJQX010000001.1 Lassopeptides: MT466_RS00850_lassopeptideNZ_JAQQGI010000001.1 Lassopeptides: PQS91_RS01155_lassopeptideNZ_JVHP01000037.1 Lassopeptides: ADI44_RS25485_lassopeptideNZ_JVPM01000019.1 Lassopeptides: ADH50_RS20965_lassopeptideNZ_JVUI01000038.1 Lassopeptides: ADG58_RS23065_lassopeptideNZ_OBEE01000001.1 Lassopeptides: CRO53_RS21815_lassopeptideNZ_OU943334.1 Lassopeptides: LNN95_RS11880_lassopeptideNZ_RHPZ01000001.1 Lassopeptides: EGJ03_RS21120_lassopeptideNZ_RHQE01000001.1 Lassopeptides: EGJ89_RS22430_lassopeptideNZ_SOCO01000001.1 Lassopeptides: N440_RS20340_lassopeptide

Lassopeptides: SMAL_RS21110_lassopeptide

WQGVVPTVS

W GV PT S

WDGVFPTTS

22.2% NZ_AP018365.1: Lanthipeptides: RVR_RS00125_lanthipeptide

SWQHVFTCC

SWQ F+CC

SWQGSFSCC

20.0% NZ_CP020040.1: Lanthipeptides: allorf_284766_284966_lanthipeptide

VPTVSYECRMNSWQHVFTCC

VP+V E R ++W+ C

VPSVDAEFRGDTWETCAPTC

18.5% NZ_AP018365.1: Lanthipeptides: RVR_RS00130_lanthipeptide

MNSWQHVFTCC

+ SW+ F+CC

IGSWEGTFSCC

14.3% NZ_NTWJ01000043.1and 5 others:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29365_lanthipeptideNZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29360_lanthipeptideNZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29370_lanthipeptideNZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29365_lanthipeptideNZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29360_lanthipeptide

Lanthipeptides: CN427_RS29370_lanthipeptide

QGVVPTVSYECR

G++ T SYEC+

DGIMCTTSYECQ

12.8% NZ_CM001558.1: Lanthipeptides: PFLQ2_RS30505_lanthipeptide

SYECRMNSWQHV

++EC S+QH

NFECDFKSYQHA

9.8% NZ_CP110813.1: Lanthipeptides: BV903_RS23420_lanthipeptide

PTVSYECRMNSWQHVFTC

P Y+CR +W+ + C

PGYYYQCRGGAWRLIAVC

7.1% NZ_BMUU01000006.1and 1 other:

NZ_NNBJ01000008.1 Lanthipeptides: CG740_RS17870_lanthipeptide

Lanthipeptides: IE233_RS19455_lanthipeptide

WQGVVPTVSYECRMNSW

W+G+ P + R+N +

WEGMYPGRGFHHRLNGF

7.1% NZ_BMUZ01000004.1and 1 other:

NZ_CP070373.1 Lanthipeptides: GWQ54_RS15650_lanthipeptide

Lanthipeptides: IE267_RS12160_lanthipeptide

WQGVVPTVSYECRMNSW

W+G P + R+N +

WEGRYPGRGFHHRLNGF

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

mutA - Class II

Cleavage pHMM score: 5.10

RODEO score: 0

Monoisotopic mass: 3243.5 Da

Molecular weight: 3245.7 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3263.7 Da N = 1