BGC0000534 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000534 (Streptococcus mutans)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-ii	1	6,359	mutacin K8	ribosomal:RiPP:Lanthipeptide	100%

BGC0000534 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 6,359 nt. (total: 6,359 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 6,360
Label		BGC0000534

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000534	1.00	RiPP	mutacin K8	Streptococcus mutans
BGC0000532	0.32	RiPP	mutacin II	Streptococcus mutans
BGC0000550	0.31	RiPP	salivaricin G32	Streptococcus salivarius
BGC0000526	0.30	RiPP	macedocin	Streptococcus macedonicus
BGC0001788	0.29	RiPP	suicin 65	Streptococcus suis
BGC0000557	0.26	RiPP	streptococcin A-FF22	Streptococcus pyogenes
BGC0000545	0.25	RiPP	ruminococcin A	[Ruminococcus] gnavus E1
BGC0000521	0.23	RiPP	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000539	0.23	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000623	0.22	RiPP	plantaricin W α, plantaricin W β	Lactobacillus plantarum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000534	1.00	RiPP	mutacin K8	Streptococcus mutans
BGC0000532	0.66	RiPP	mutacin II	Streptococcus mutans
BGC0000550	0.65	RiPP	salivaricin G32	Streptococcus salivarius
BGC0000526	0.64	RiPP	macedocin	Streptococcus macedonicus
BGC0001788	0.63	RiPP	suicin 65	Streptococcus suis
BGC0000557	0.60	RiPP	streptococcin A-FF22	Streptococcus pyogenes
BGC0000545	0.59	RiPP	ruminococcin A	[Ruminococcus] gnavus E1
BGC0000521	0.56	RiPP	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000539	0.56	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000623	0.55	RiPP	plantaricin W α, plantaricin W β	Lactobacillus plantarum

Similar known gene clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for mukM

mukA1

Leader:

MKNTTNEMLELIQEVSLDELDQVIGG

mukA3

Leader:

MKQSNEMLELIQEVSLDELDQVIGG

Shared core:

MGKGAVGTISHECRYNSWAFLATCCS

Core with dehydrations:

MGKGAVGDhbIDhaHECysRYNDhaWAFLADhbCysCysDha

antiSMASH-DB 4.0 matches for mukA1

100.0% NC_013928.1and 8 others:

NC_013928.1 Lanthipeptides: SMUNN2025_RS01700_lanthipeptideNZ_CP023477.1 Lanthipeptides: CO204_RS01885_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01090_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01080_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01745_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01735_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07575_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07565_lanthipeptide

Lanthipeptides: SMUNN2025_RS01710_lanthipeptide

MGKGAVGTISHECRYNSWAFLATCCS

96.2% NZ_CP023477.1: Lanthipeptides: CO204_RS01875_lanthipeptide

MGKGAVGTISHECRYNSWAFLATCCS

MGKG VGTISHECRYNSWAFLATCCS

MGKGTVGTISHECRYNSWAFLATCCS

69.2% NZ_CP018188.1and 17 others:

NZ_CP018188.1 Lanthipeptides: BSR19_RS11175_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07300_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07295_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09705_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09700_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09300_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09295_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09300_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09295_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06585_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06580_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06585_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06580_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05120_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05115_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04335_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04330_lanthipeptide

Lanthipeptides: BSR19_RS11180_lanthipeptide

GKGAVGTISHECRYNSWAFLATCCS

G G TISHEC N+WAFLATCCS

GNGVFKTISHECHLNTWAFLATCCS

with 67 more sequence matches

69.2% NZ_VDNV01000006.1: Lanthipeptides: FSV44_RS08765_lanthipeptide

GKGAVGTISHECRYNSWAFLATCCS

G G + TISHECR NSW FL TCCS

GGGVIQTISHECRMNSWQFLFTCCS

65.4% NC_012470.1and 2 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06490_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09840_lanthipeptide

Lanthipeptides: SZO_RS04065_lanthipeptide

GAVGTISHECRYNSWAFLATCCS

GA+ TISHEC NSW FL TCCS

GAIKTISHECHMNSWQFLFTCCS

65.4% NZ_ALSD01000046.1and 49 others:

NZ_CAAHGW010000010.1 Lanthipeptides: E9435_RS08890_lanthipeptideNZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS02935_lanthipeptideNZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08685_lanthipeptideNZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08680_lanthipeptideNZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05700_lanthipeptideNZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08730_lanthipeptideNZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08725_lanthipeptideNZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08980_lanthipeptideNZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08975_lanthipeptideNZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01070_lanthipeptideNZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09265_lanthipeptideNZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09260_lanthipeptideNZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08765_lanthipeptideNZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08760_lanthipeptideNZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08915_lanthipeptideNZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08910_lanthipeptideNZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02170_lanthipeptideNZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09655_lanthipeptideNZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03455_lanthipeptideNZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03450_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08825_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08820_lanthipeptideNZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03170_lanthipeptideNZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02470_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08470_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08465_lanthipeptideNZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09580_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09035_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09030_lanthipeptideNZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08495_lanthipeptideNZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08490_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08505_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08500_lanthipeptideNZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06790_lanthipeptideNZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06785_lanthipeptideNZ_CM001076.1 Lanthipeptides: SDD27957_RS04310_lanthipeptideNZ_CM001076.1 Lanthipeptides: SDD27957_RS04305_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02595_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02590_lanthipeptideNZ_CP035428.1 Lanthipeptides: ETT71_RS02815_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06680_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06675_lanthipeptideNZ_CP035443.1 Lanthipeptides: ETT56_RS07265_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS105315_lanthipeptideNZ_LR793258.1 Lanthipeptides: HV369_RS03145_lanthipeptideNZ_LR793258.1 Lanthipeptides: HV369_RS03140_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06755_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06750_lanthipeptideNZ_LT545678.1 Lanthipeptides: BJR96_RS07040_lanthipeptide

Lanthipeptides: SAG0161_RS120605_lanthipeptide

KGAVGTISHECRYNSWAFLATCCS

G TISHEC N+WAFLATCCS

NGVFKTISHECHLNTWAFLATCCS

65.4% NZ_CP023483.1: Lanthipeptides: CNY62_RS11970_lanthipeptide

GKGAVGTISHECRYNSWAFLATCCS

G GA+ TISHEC N+W FL TCCS

GNGAIRTISHECHMNTWQFLFTCCS

65.4% NZ_CP026729.1: Lanthipeptides: BKKJ1_RS07010_lanthipeptide

GKGAVGTISHECRYNSWAFLATCC

G G V TISHEC NSW FL TCC

GNGVVTTISHECNMNSWQFLFTCC

65.4% NZ_GL985606.1: Lanthipeptides: HMPREF9062_RS00700_lanthipeptide

GKGAVGTISHECRYNSWAFLATCC

G G TISHEC YNSWAF+ TCC

GNGVFHTISHECYYNSWAFIFTCC

61.5% NC_012470.1and 11 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06485_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05185_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05180_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09835_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09830_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05350_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05345_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05065_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05060_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05580_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05575_lanthipeptide

Lanthipeptides: SZO_RS04070_lanthipeptide

GAVGTISHECRYNSWAFLATCCS

G TISHEC NSW FL TCCS

GVFKTISHECHMNSWQFLFTCCS

61.5% NZ_CAAHKQ010000003.1: Lanthipeptides: E9664_RS02165_lanthipeptide

KGAVGTISHECRYNSWAFLATCCS

G TISHEC N+WAFLA CCS

NGVFKTISHECHLNTWAFLAICCS

61.5% NZ_CP060646.1: Lanthipeptides: H7789_RS06845_lanthipeptide

KGAVGTISHECRYNSWAFLATCCS

G TISHEC N+WA LATCCS

NGVFKTISHECHLNTWASLATCCS

61.5% NZ_MSRJ01000005.1: Lanthipeptides: BKH06_RS03755_lanthipeptide

KGAVGTISHECRYNSWAFLATCCS

+G V TISHEC NSW F+ TCCS

EGVVTTISHECNMNSWQFIFTCCS

61.5% NZ_WBPF01000002.1: Lanthipeptides: F8162_RS00195_lanthipeptide

GKGAVGTISHECRYNSWAFLATCCS

KG TISHEC +N+W FL TCCS

DKGQFDTISHECHWNTWQFLFTCCS

59.3% NZ_CP046629.1and 3 others:

NZ_FNJX01000002.1 Lanthipeptides: BLR40_RS05025_lanthipeptideNZ_FNZS01000001.1 Lanthipeptides: BMX70_RS03125_lanthipeptideNZ_FOLK01000002.1 Lanthipeptides: BM262_RS05670_lanthipeptide

Lanthipeptides: GPA00_RS05740_lanthipeptide

GKGAVGTISHECRYNSWAFLATCCS

G G V T+SH+C NSW FL TCCS

GSGVVPTVSHDCHMNSWQFLFTCCS

59.3% NZ_CP069183.1: Lanthipeptides: LLNCDO700_RS13730_lanthipeptide

GKGAVGTISHECRYNSWAFLATCCS

G G + TISHEC NSW F+ TCCS

GSGVIHTISHECNMNSWQFVFTCCS

57.7% NZ_AP025017.1: Lanthipeptides: MANAM107_RS05920_lanthipeptide

KGAVGTISHECRYNSWAFLATCCS

G + TISHEC N+WAF TCCS

NGVITTISHECHLNTWAFAFTCCS

57.7% NZ_CP084014.1and 6 others:

NZ_CP084014.1 Lanthipeptides: LCQ72_RS00100_lanthipeptideNZ_CP084014.1 Lanthipeptides: LCQ72_RS00095_lanthipeptideNZ_CP094679.1 Lanthipeptides: K5I24_RS13105_lanthipeptideNZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12415_lanthipeptideNZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12410_lanthipeptideNZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12405_lanthipeptide

Lanthipeptides: LCQ72_RS00105_lanthipeptide

GKGAVGTISHECRYNSWAFLATCC

G G + TISHEC N+W FL TCC

GNGVLKTISHECNMNTWQFLFTCC

57.7% NZ_FOZB01000002.1: Lanthipeptides: BM306_RS07850_lanthipeptide

GKGAVGTISHECRYNSWAFLATCCS

G G TISHEC N+W F+ TCCS

GDGVFRTISHECHMNTWMFIFTCCS

57.7% NZ_GL882519.1: Lanthipeptides: HMPREF9056_RS03330_lanthipeptide

GKGAVGTISHECRYNSWAFLATCCS

G G T+SHEC NSW F+ TCCS

GNGVYYTLSHECHMNSWQFIFTCCS

57.7% NZ_JAEEGA010000010.1: Lanthipeptides: I6N95_RS15660_lanthipeptide

GKGAVGTISHECRYNSWAFLATCCS

G G + TISHEC NSW ++ TCCS

GNGVIKTISHECHMNSWQWIFTCCS

57.7% NZ_JH792236.1and 1 other:

NZ_JH792236.1 Lanthipeptides: IIM_RS26240_lanthipeptide

Lanthipeptides: IIM_RS26245_lanthipeptide

GKGAVGTISHECRYNSWAFLATCCS

G G + TISHEC NSW + TCCS

GSGVIKTISHECHMNSWQAIFTCCS

57.7% NZ_LT732526.1and 1 other:

NZ_LT732526.1 Lanthipeptides: BQ9856_RS23075_lanthipeptide

Lanthipeptides: BQ9856_RS23080_lanthipeptide

GKGAVGTISHECRYNSWAFLATCCS

G G + TISHEC N+W F+ TCCS

GNGVIKTISHECAMNTWQFIFTCCS

57.7% NZ_VMMF01000004.1: Lanthipeptides: HT717_RS01580_lanthipeptide

GKG-AVGTISHECRYNSWAFLATCC

GKG V TIS ECR+NS + TCC

GKGHGVNTISAECRWNSLQAIFTCC

53.8% NZ_NWMU01000024.1: Lanthipeptides: CO197_RS09155_lanthipeptide

GKG-AVGTISHECRYNSWAFLATCC

G+G V TIS ECR+NS + TCC

GRGHGVNTISAECRWNSLQAIFTCC

53.8% NZ_NWMU01000024.1and 3 others:

NZ_NWMU01000024.1 Lanthipeptides: CO197_RS09145_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01575_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01570_lanthipeptide

Lanthipeptides: CO197_RS09150_lanthipeptide

GAVGTISHECRYNSWAFLATCCS

G TISHEC NS+ F TCCS

GVFKTISHECHMNSFQFFFTCCS

53.8% NZ_QTVL01000002.1and 5 others:

NZ_QTVL01000002.1 Lanthipeptides: DWZ44_RS04150_lanthipeptideNZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14340_lanthipeptideNZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14335_lanthipeptideNZ_QUKU01000003.1 Lanthipeptides: DXC27_RS02940_lanthipeptideNZ_QUKU01000003.1 Lanthipeptides: DXC27_RS02935_lanthipeptide

Lanthipeptides: DWZ44_RS04155_lanthipeptide

GKGAVGTISHECRYNSWAFLATCC

G G TISHEC N+W F+ TCC

GDGVFRTISHECNMNTWQFIFTCC

50.0% NZ_CAAHHE010000002.1and 13 others:

NZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08675_lanthipeptideNZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05705_lanthipeptideNZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08735_lanthipeptideNZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08985_lanthipeptideNZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01075_lanthipeptideNZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09255_lanthipeptideNZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08920_lanthipeptideNZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09650_lanthipeptideNZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03445_lanthipeptideNZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03175_lanthipeptideNZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02475_lanthipeptideNZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09585_lanthipeptideNZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08485_lanthipeptide

Lanthipeptides: E9499_RS02930_lanthipeptide

GKGAVGTISHECRYNSWAFLATCC

G V TIS ECR+NS + TCC

GGHGVNTISAECRWNSLQAIFTCC

50.0% NZ_CP031746.1: Lanthipeptides: DCC27_RS08165_lanthipeptide

KGAVGTISHECRYNSWAFLATCCS

G + T++HEC NSW L TCCS

DGVISTLTHECHMNSWQGLLTCCS

50.0% NZ_CP046956.1: Lanthipeptides: ERJ70_RS03695_lanthipeptide

KGAVGTISHECRYNSWAFLATCC

GA+ T+SHEC N+W F+ TCC

DGAISTVSHECHMNTWQFIFTCC

50.0% NZ_CP083176.1and 4 others:

NZ_JABUHD010000002.1 Lanthipeptides: HRR08_RS05415_lanthipeptideNZ_LSLF01000001.1 Lanthipeptides: AXE72_RS04025_lanthipeptideNZ_PNHB01000001.1 Lanthipeptides: CJ210_RS02800_lanthipeptideNZ_QJVA01000001.1 Lanthipeptides: D0T19_RS02755_lanthipeptide

Lanthipeptides: K9E37_RS06280_lanthipeptide

GKGAVGTISHECRYNSWAFLATCC

G G + T++HEC N+W FL TCC

GDGVMHTLTHECHMNTWQFLLTCC

50.0% NZ_JAHBEV010000004.1and 3 others:

NZ_JAHBEX010000010.1 Lanthipeptides: KII86_RS06785_lanthipeptideNZ_JAHBFD010000039.1 Lanthipeptides: KIJ16_RS07340_lanthipeptideNZ_LN890331.1 Lanthipeptides: LEKG_RS02295_lanthipeptide

Lanthipeptides: KII98_RS01100_lanthipeptide

GAVGTISHECRYNSWAFLATCCS

G + T+SHEC NSW F+ TCC+

GVINTVSHECNMNSWQFVFTCCA

50.0% NZ_MSRU01000008.1: Lanthipeptides: BKH03_RS04355_lanthipeptide

GKGAVGTISHECRYNSWAFLATCCS

G G +I+HEC NS L TCCS

GDGVKWSITHECYMNSLQVLLTCCS

48.4% NZ_CP034248.1: Lanthipeptides: EIM92_RS14995_lanthipeptide

GAVGTISHECRYNSW--AFLATCC

G + TISHEC YNS A ATCC

GVICTISHECHYNSVSPAAWATCC

48.1% NZ_CP044492.1and 1 other:

NZ_CP066294.2 Lanthipeptides: IGS65_RS08185_lanthipeptide

Lanthipeptides: FSA31_RS00605_lanthipeptide

KGAVGTISHECRYNSWAFLATCC

+G V T+S+ECR NSW + TCC

QGVVPTVSYECRMNSWQHVFTCC

48.1% NZ_FNUH01000004.1and 1 other:

NZ_FOGM01000011.1 Lanthipeptides: BMX20_RS07220_lanthipeptide

Lanthipeptides: BLU50_RS05815_lanthipeptide

KGAVGTISHECRYNSWAFLATCC

+G V T+S+ECR NSW + TCC

QGVVPTVSYECRMNSWQSIFTCC

46.2% NC_012470.1and 26 others:

NZ_CAAHGW010000010.1 Lanthipeptides: E9435_RS08895_lanthipeptideNZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08770_lanthipeptideNZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02160_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08815_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08475_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09025_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08495_lanthipeptideNZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS10120_lanthipeptideNZ_CP018188.1 Lanthipeptides: BSR19_RS11185_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05190_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02600_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06670_lanthipeptideNZ_CP035443.1 Lanthipeptides: ETT56_RS07260_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07305_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09825_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05340_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09695_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS10860_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05070_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06745_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04325_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05570_lanthipeptide

Lanthipeptides: SZO_RS10260_lanthipeptide

VGTISHECRYNSWAFLATCC

V TIS ECR+NS + TCC

VNTISAECRWNSLQAIFTCC

46.2% NZ_CP072384.1: Lanthipeptides: J5A65_RS01395_lanthipeptide

GKGAVGTISHECRYNSWAFLATCC

G+G V T++HEC NSW + CC

GRGVVPTVTHECHMNSWQWFFGCC

46.2% NZ_MSRJ01000005.1: Lanthipeptides: BKH06_RS03750_lanthipeptide

GKGAVGTISHECRYNSWAFLATCCS

G G T +HEC NS+ TCCS

GNGVFYTFTHECNTNSFYVAFTCCS

44.4% NZ_CP049223.1and 4 others:

NZ_CP049225.1 Lanthipeptides: G6Z85_RS06555_lanthipeptideNZ_CP049228.1 Lanthipeptides: G6Z83_RS06555_lanthipeptideNZ_JAKWZB010000003.1 Lanthipeptides: MMO78_RS01405_lanthipeptideNZ_PNGO01000002.1 Lanthipeptides: CJ224_RS02730_lanthipeptide

Lanthipeptides: G6Z86_RS06445_lanthipeptide

KGAVGTISHECRYNSWAFLATCC

+G + T+SHECR NS+ + TCC

QGVLPTVSHECRMNSFQHIFTCC

44.4% NZ_CP051645.1and 2 others:

NZ_JAKVFF010000018.1 Lanthipeptides: MKR34_RS11425_lanthipeptideNZ_VDOJ01000018.1 Lanthipeptides: FSV48_RS11975_lanthipeptide

Lanthipeptides: HHJ99_RS13350_lanthipeptide

GAVGTISHECRYNSWAFLATCCS

G + T+SH+C NS+ F+ TCCS

GVIPTVSHDCHMNSFQFVFTCCS

42.3% NC_013928.1and 4 others:

NZ_CP023477.1 Lanthipeptides: CO204_RS01890_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01095_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01750_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07560_lanthipeptide

Lanthipeptides: SMUNN2025_RS09965_lanthipeptide

GKGAVGTISHECRYNSWAFLATCC

G A TIS +CR+NS + +CC

GGRASNTISSDCRWNSLQAIFSCC

42.3% NZ_ALSD01000046.1and 5 others:

NZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06795_lanthipeptideNZ_CM001076.1 Lanthipeptides: SDD27957_RS10995_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS1000000113590_lanthipeptideNZ_LR793258.1 Lanthipeptides: HV369_RS03150_lanthipeptideNZ_LT545678.1 Lanthipeptides: BJR96_RS11590_lanthipeptide

Lanthipeptides: SAG0161_RS1000000124770_lanthipeptide

VGTISHECRYNSWAFLATCC

V TIS ECR+NS + +CC

VNTISAECRWNSLQAIFSCC

40.7% NZ_CP046304.1: Lanthipeptides: FOC54_RS00030_lanthipeptide

GAVGTISHECRYNSWAFLATCCS

G + T+SH+C N++ F+ TCCS

GVIPTVSHDCHMNTFQFMFTCCS

38.5% NC_013928.1and 4 others:

NZ_CP023477.1 Lanthipeptides: CO204_RS01880_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01085_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01740_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07570_lanthipeptide

Lanthipeptides: SMUNN2025_RS01705_lanthipeptide

GKGAVGTISHECRY-NSWAFLATC

G G + TI+ CR N+ L TC

GNGVIRTITQGCRMPNNMQVLFTC

38.5% NC_015760.1and 5 others:

NZ_CAJHJN010000010.1 Lanthipeptides: JMZ68_RS09030_lanthipeptideNZ_JACLQK010000036.1 Lanthipeptides: H7U04_RS11500_lanthipeptideNZ_JADPEB010000003.1 Lanthipeptides: I4U26_RS02800_lanthipeptideNZ_JAQCST010000021.1 Lanthipeptides: PGZ09_RS09470_lanthipeptideNZ_OU540596.1 Lanthipeptides: JQ838_RS05640_lanthipeptide

Lanthipeptides: SALIVB_RS03310_lanthipeptide

GKGAVGTISHECRYNSWAFLATCC

G G V T++HEC +W CC

GNGVVLTLTHECNLATWTKKLKCC

38.5% NZ_CP086242.1and 1 other:

NZ_CP086245.1 Lanthipeptides: LL037_RS25615_lanthipeptide

Lanthipeptides: LL038_RS25355_lanthipeptide

KGAVGTISHECRYNSWAFLATCC

GA+ T + EC Y F A CC

SGAICTATTECTY----FSAICC

38.5% NZ_CP117876.1: Lanthipeptides: PQ460_RS01735_lanthipeptide

GKGAVGTISHECRYNSWAFLATCC

G G V T + EC + AF+ CC

GDGVVKTATSECYLGTVAFI--CC

38.5% NZ_JAFCGV010000005.1: Lanthipeptides: JQI09_RS04275_lanthipeptide

GKGAVGTISHECRYNSWAFLATCC

G G V T + EC ++AF+ CC

GDGVVKTATSECYLGTFAFV--CC

38.5% NZ_LR134406.1: Lanthipeptides: EL272_RS00695_lanthipeptide

GKGAVGTISHECRYNSWAFLATCC

G G++ + +HEC N+ L TCC

GWGSIFSFTHECNTNTMTQLFTCC

37.0% NZ_CP037940.1: Lanthipeptides: EQG49_RS07315_lanthipeptide

GKGAVGTISHECRYNSWAFLATCC

G G + T++HEC+ N++ + TCC

GSGVIKTLTHECKMNTYQAILTCC

33.3% NZ_CP077726.1and 12 others:

NZ_CP077726.1 Lanthipeptides: KTC92_RS18420_lanthipeptideNZ_CP077726.1 Lanthipeptides: KTC92_RS18415_lanthipeptideNZ_CP077726.1 Lanthipeptides: KTC92_RS18410_lanthipeptideNZ_CP077726.1 Lanthipeptides: KTC92_RS18405_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19070_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19065_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19060_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19055_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19050_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19045_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19040_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19035_lanthipeptide

Lanthipeptides: KTC92_RS18425_lanthipeptide

GKGAVGTISHECRYNS

G G + T +HEC YNS

GNGVITTFTHECYYNS

33.3% NZ_CP086142.1and 3 others:

NZ_CP086142.1 Lanthipeptides: LL065_RS25460_lanthipeptideNZ_CP086142.1 Lanthipeptides: LL065_RS25455_lanthipeptideNZ_CP086142.1 Lanthipeptides: LL065_RS25450_lanthipeptide

Lanthipeptides: LL065_RS25465_lanthipeptide

GKGAVGTISHECRYNS

G G + T +HEC YNS

GGGVITTFTHECYYNS

30.8% NZ_CP045267.1and 1 other:

NZ_CP045267.1 Lanthipeptides: FDZ14_RS00155_lanthipeptide

Lanthipeptides: FDZ14_RS00155_lanthipeptide

GKGAVGTISHECRYNSWAF

G G V T + EC ++AF

GDGVVKTATSECYLGTFAF

30.8% NZ_CP060646.1: Lanthipeptides: H7789_RS06840_lanthipeptide

GKGAVGTISHECR

G V TIS ECR

GGHGVNTISAECR

26.7% NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide

Lanthipeptides: EI692_RS18440_lanthipeptide

KGAVGTISHEC

KG TISHEC

KGGWCTISHEC

26.5% NZ_CAKMMP010000011.1and 5 others:

NZ_CP018620.1 Lanthipeptides: BS614_RS05680_lanthipeptideNZ_CP062165.1 Lanthipeptides: JNUCC31_RS16755_lanthipeptideNZ_FMVM01000006.1 Lanthipeptides: BLQ13_RS10365_lanthipeptideNZ_RIAS01000010.1 Lanthipeptides: EC604_RS18225_lanthipeptideNZ_VEJI01000010.1 Lanthipeptides: FS576_RS22075_lanthipeptide

Lanthipeptides: L6H98_RS19925_lanthipeptide

GAVGTISHECRYNS

G T+SHEC YNS

GVFCTVSHECHYNS

25.9% NZ_CP071875.1: Lanthipeptides: J4I02_RS02880_lanthipeptide

GAVGTISHECRYNSW

GA+ T++HEC W

GAICTLTHECAGTHW

25.0% NZ_CP036016.1: Lanthipeptides: allorf_072682_072798_lanthipeptide

VGTISHECRYNSWAFLATC

V + H+ YN A+ TC

VVLLFHKVEYNRMAYFITC

24.1% NZ_CP036016.1: Lanthipeptides: allorf_075467_075682_lanthipeptide

GKGAVGTISHECRYNSW

G+ T+S ECR W

NDGSTCTLSVECRPACW

24.1% NZ_CP084541.1: Lanthipeptides: LC193_RS09330_lanthipeptide

GTISHECRYNSWAFLATC

+I + C++ S+A L+TC

NSIINGCQWQSFAILSTC

24.1% NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21835_lanthipeptide

Lanthipeptides: CN325_RS21835_lanthipeptide

GKGAVGTISHECRYNSW

G+V T++ ECR W

NDGSVCTLTKECRPACW

21.2% NZ_AP024169.1: Lanthipeptides: bsdtb5_RS06100_lanthipeptide

GAVGTISHEC

GAV T+S+EC

GAVPTLSYEC

21.2% NZ_AP024169.1: Lanthipeptides: bsdtb5_RS06110_lanthipeptide

GAVGTISHECRYNS

G TIS+EC N+

GGFPTISYECTSNN

21.2% NZ_AP024169.1: Lanthipeptides: bsdtb5_RS06105_lanthipeptide

GAVGTISHECRYNSWA

G + TIS+EC N+ +

GRMPTISYECTSNNVS

19.4% NZ_CP102975.1and 1 other:

NZ_FMOE01000002.1 Lanthipeptides: BJT27_RS07805_lanthipeptide

Lanthipeptides: NW953_RS00170_lanthipeptide

KGAVGTISHEC

G + T+SHEC

NGKLCTVSHEC

13.6% NZ_CP031058.1: Lanthipeptides: allorf_3313863_3314099_lanthipeptide

MGKGAVGTISHECR---YNSW

+GK VG ++ CR N W

LGKTRVGLLAQPCRAHAPNPW

10.0% NZ_CP015405.2and 1 other:

NZ_CP053228.1 Lanthipeptides: HL650_RS16700_lanthipeptide

Lanthipeptides: A4V09_RS22690_lanthipeptide

RYNSWAFLATC

+YN W ++ +C

QYNVWDYIYSC

10.0% NZ_JAAOYX010000001.1: Lanthipeptides: allorf_2623536_2623727_lanthipeptide

YNSWAFLATC

++ +AFLA C

HDGYAFLAPC

8.2% NZ_CP110813.1: Lanthipeptides: BV903_RS23420_lanthipeptide

HECRYNSWAFLATC

++CR +W +A C

YQCRGGAWRLIAVC

MIBiG 3.1 matches for mukA1

21.4% BGC0000517 (BAB04173.1): Lanthipeptide: haloduracin β or haloduracin α

GKGAVGTISHEC

KGA T++ EC

NKGAYCTLTVEC

12.8% BGC0001229 (SBI_06990): Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

TISHECRYN

T+S EC+ N

TLSKECQPN

mukA2

Leader:

MKQSDEMLELIQEVSLDELDQVIGG

Core:

AGNGVIRTITQGCRMPNNMQVLFTC

Core with dehydrations:

AGNGVIRDhbIDhbQGCysRMPNNMQVLFDhbCys

antiSMASH-DB 4.0 matches for mukA2

100.0% NC_013928.1and 4 others:

Lanthipeptides: SMUNN2025_RS01705_lanthipeptide

AGNGVIRTITQGCRMPNNMQVLFTC

60.0% NZ_CP023483.1: Lanthipeptides: CNY62_RS11970_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

GNG IRTI+ C M N Q LFTC

GNGAIRTISHECHM-NTWQFLFTC

60.0% NZ_VDNV01000006.1: Lanthipeptides: FSV44_RS08765_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

G GVI+TI+ CRM N+ Q LFTC

GGGVIQTISHECRM-NSWQFLFTC

with 45 more sequence matches

56.0% NZ_CP026729.1: Lanthipeptides: BKKJ1_RS07010_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

GNGV+ TI+ C M N+ Q LFTC

GNGVVTTISHECNM-NSWQFLFTC

56.0% NZ_CP084014.1and 6 others:

Lanthipeptides: LCQ72_RS00105_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

GNGV++TI+ C M N Q LFTC

GNGVLKTISHECNM-NTWQFLFTC

56.0% NZ_JAEEGA010000010.1: Lanthipeptides: I6N95_RS15660_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

GNGVI+TI+ C M N+ Q +FTC

GNGVIKTISHECHM-NSWQWIFTC

56.0% NZ_LT732526.1and 1 other:

NZ_LT732526.1 Lanthipeptides: BQ9856_RS23075_lanthipeptide

Lanthipeptides: BQ9856_RS23080_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

GNGVI+TI+ C M N Q +FTC

GNGVIKTISHECAM-NTWQFIFTC

52.0% NZ_JH792236.1and 1 other:

NZ_JH792236.1 Lanthipeptides: IIM_RS26240_lanthipeptide

Lanthipeptides: IIM_RS26245_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

G+GVI+TI+ C M N+ Q +FTC

GSGVIKTISHECHM-NSWQAIFTC

52.0% NZ_QTVL01000002.1and 5 others:

Lanthipeptides: DWZ44_RS04155_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

G+GV RTI+ C M N Q +FTC

GDGVFRTISHECNM-NTWQFIFTC

50.0% NC_012470.1and 2 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06490_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09840_lanthipeptide

Lanthipeptides: SZO_RS04065_lanthipeptide

NGVIRTITQGCRMPNNMQVLFTC

NG I+TI+ C M N+ Q LFTC

NGAIKTISHECHM-NSWQFLFTC

50.0% NC_012470.1and 11 others:

Lanthipeptides: SZO_RS04070_lanthipeptide

NGVIRTITQGCRMPNNMQVLFTC

NGV +TI+ C M N+ Q LFTC

NGVFKTISHECHM-NSWQFLFTC

50.0% NZ_MSRU01000008.1: Lanthipeptides: BKH03_RS04355_lanthipeptide

AGNGVIRTITQGCRMPNNMQVLFTC

G+GV +IT C M N++QVL TC

GGDGVKWSITHECYM-NSLQVLLTC

48.1% NZ_CP069183.1: Lanthipeptides: LLNCDO700_RS13730_lanthipeptide

AGNGVIRTITQGCRMPNNMQVLFTC

G+GVI TI+ C M N+ Q +FTC

GGSGVIHTISHECNM-NSWQFVFTC

48.0% NZ_CP031746.1: Lanthipeptides: DCC27_RS08165_lanthipeptide

NGVIRTITQGCRMPNNMQVLFTC

+GVI T+T C M N+ Q L TC

DGVISTLTHECHM-NSWQGLLTC

48.0% NZ_CP083176.1and 4 others:

Lanthipeptides: K9E37_RS06280_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

G+GV+ T+T C M N Q L TC

GDGVMHTLTHECHM-NTWQFLLTC

48.0% NZ_FOZB01000002.1: Lanthipeptides: BM306_RS07850_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

G+GV RTI+ C M N +FTC

GDGVFRTISHECHM-NTWMFIFTC

48.0% NZ_GL882519.1: Lanthipeptides: HMPREF9056_RS03330_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

GNGV T++ C M N+ Q +FTC

GNGVYYTLSHECHM-NSWQFIFTC

48.0% NZ_NWMU01000024.1and 1 other:

NZ_VMMF01000004.1 Lanthipeptides: HT717_RS01580_lanthipeptide

Lanthipeptides: CO197_RS09155_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

G+GV TI+ CR N++Q +FTC

GHGV-NTISAECRW-NSLQAIFTC

46.2% NZ_NWMU01000024.1and 3 others:

NZ_NWMU01000024.1 Lanthipeptides: CO197_RS09145_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01575_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01570_lanthipeptide

Lanthipeptides: CO197_RS09150_lanthipeptide

NGVIRTITQGCRMPNNMQVLFTC

NGV +TI+ C M N+ Q FTC

NGVFKTISHECHM-NSFQFFFTC

44.4% NZ_CP037940.1: Lanthipeptides: EQG49_RS07315_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

G+GVI+T+T C+M N Q + TC

GSGVIKTLTHECKM-NTYQAILTC

44.4% NZ_CP046629.1and 3 others:

NZ_FNJX01000002.1 Lanthipeptides: BLR40_RS05025_lanthipeptideNZ_FNZS01000001.1 Lanthipeptides: BMX70_RS03125_lanthipeptideNZ_FOLK01000002.1 Lanthipeptides: BM262_RS05670_lanthipeptide

Lanthipeptides: GPA00_RS05740_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

G+GV+ T++ C M N+ Q LFTC

GSGVVPTVSHDCHM-NSWQFLFTC

44.0% NZ_AP025017.1: Lanthipeptides: MANAM107_RS05920_lanthipeptide

NGVIRTITQGCRMPNNMQVLFTC

NGVI TI+ C + N FTC

NGVITTISHECHL-NTWAFAFTC

44.0% NZ_CP018188.1and 17 others:

Lanthipeptides: BSR19_RS11180_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

GNGV +TI+ C + N L TC

GNGVFKTISHECHL-NTWAFLATC

44.0% NZ_CP072384.1: Lanthipeptides: J5A65_RS01395_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

G GV+ T+T C M N+ Q F C

GRGVVPTVTHECHM-NSWQWFFGC

44.0% NZ_LR134406.1: Lanthipeptides: EL272_RS00695_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

G G I + T C N M LFTC

GWGSIFSFTHECN-TNTMTQLFTC

44.0% NZ_MSRJ01000005.1: Lanthipeptides: BKH06_RS03755_lanthipeptide

NGVIRTITQGCRMPNNMQVLFTC

GV+ TI+ C M N+ Q +FTC

EGVVTTISHECNM-NSWQFIFTC

42.3% NZ_JAHBEV010000004.1and 3 others:

NZ_JAHBEX010000010.1 Lanthipeptides: KII86_RS06785_lanthipeptideNZ_JAHBFD010000039.1 Lanthipeptides: KIJ16_RS07340_lanthipeptideNZ_LN890331.1 Lanthipeptides: LEKG_RS02295_lanthipeptide

Lanthipeptides: KII98_RS01100_lanthipeptide

NGVIRTITQGCRMPNNMQVLFTC

+GVI T++ C M N+ Q +FTC

SGVINTVSHECNM-NSWQFVFTC

40.7% NZ_CP044492.1and 1 other:

NZ_CP066294.2 Lanthipeptides: IGS65_RS08185_lanthipeptide

Lanthipeptides: FSA31_RS00605_lanthipeptide

GVIRTITQGCRMPNNMQVLFTC

GV+ T++ CRM N+ Q +FTC

GVVPTVSYECRM-NSWQHVFTC

40.7% NZ_CP046304.1: Lanthipeptides: FOC54_RS00030_lanthipeptide

NGVIRTITQGCRMPNNMQVLFTC

+GVI T++ C M N Q +FTC

SGVIPTVSHDCHM-NTFQFMFTC

40.7% NZ_CP049223.1and 4 others:

Lanthipeptides: G6Z86_RS06445_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

GV+ T++ CRM N+ Q +FTC

WQGVLPTVSHECRM-NSFQHIFTC

40.7% NZ_CP051645.1and 2 others:

NZ_JAKVFF010000018.1 Lanthipeptides: MKR34_RS11425_lanthipeptideNZ_VDOJ01000018.1 Lanthipeptides: FSV48_RS11975_lanthipeptide

Lanthipeptides: HHJ99_RS13350_lanthipeptide

NGVIRTITQGCRMPNNMQVLFTC

+GVI T++ C M N+ Q +FTC

SGVIPTVSHDCHM-NSFQFVFTC

40.7% NZ_FNUH01000004.1and 1 other:

NZ_FOGM01000011.1 Lanthipeptides: BMX20_RS07220_lanthipeptide

Lanthipeptides: BLU50_RS05815_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

GV+ T++ CRM N+ Q +FTC

WQGVVPTVSYECRM-NSWQSIFTC

40.0% NZ_MJEH01000022.1and 2 others:

NZ_MJEH01000022.1 Lanthipeptides: BFG57_RS18360_lanthipeptideNZ_MJEH01000022.1 Lanthipeptides: BFG57_RS09480_lanthipeptide

Lanthipeptides: BFG57_RS18365_lanthipeptide

GNGVIRTITQGCRMPNNMQV

G+G I TIT C PN++ V

GDGWISTITDDC--PNSIIV

38.5% NC_013928.1and 8 others:

Lanthipeptides: SMUNN2025_RS01710_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

G G + TI+ CR N+ L TC

GKGAVGTISHECRY-NSWAFLATC

38.5% NZ_ALSD01000046.1and 49 others:

Lanthipeptides: SAG0161_RS120605_lanthipeptide

NGVIRTITQGCRMPNNMQVLFTC

NGV +TI+ C + N L TC

NGVFKTISHECHL-NTWAFLATC

38.5% NZ_CP023477.1: Lanthipeptides: CO204_RS01875_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

G G + TI+ CR N+ L TC

GKGTVGTISHECRY-NSWAFLATC

38.5% NZ_CP060646.1: Lanthipeptides: H7789_RS06845_lanthipeptide

NGVIRTITQGCRMPNNMQVLFTC

NGV +TI+ C + N L TC

NGVFKTISHECHL-NTWASLATC

36.0% NC_004070.1and 26 others:

NC_008024.1 Lanthipeptides: MGAS10750_RS08460_lanthipeptideNZ_CAAHHZ010000002.1 Lanthipeptides: E9518_RS02835_lanthipeptideNZ_CAAHIH010000002.1 Lanthipeptides: E9602_RS03585_lanthipeptideNZ_CAAHIO010000002.1 Lanthipeptides: E9584_RS04360_lanthipeptideNZ_CAAHJE010000002.1 Lanthipeptides: E9605_RS03435_lanthipeptideNZ_CAAHJS010000002.1 Lanthipeptides: E9628_RS02300_lanthipeptideNZ_CAAHKC010000012.1 Lanthipeptides: E9636_RS08085_lanthipeptideNZ_CAAHMR010000003.1 Lanthipeptides: E9727_RS05510_lanthipeptideNZ_CAAHQE010000003.1 Lanthipeptides: E9931_RS04945_lanthipeptideNZ_CAAHQG010000004.1 Lanthipeptides: E9903_RS05690_lanthipeptideNZ_CAAIFD010000008.1 Lanthipeptides: FAG63_RS07845_lanthipeptideNZ_CAAJDK010000010.1 Lanthipeptides: FAO79_RS08000_lanthipeptideNZ_CAAJFI010000003.1 Lanthipeptides: FAP60_RS03740_lanthipeptideNZ_CP008926.1 Lanthipeptides: DP15_RS03855_lanthipeptideNZ_CP035434.1 Lanthipeptides: ETT65_RS08240_lanthipeptideNZ_CP035435.1 Lanthipeptides: ETT64_RS07905_lanthipeptideNZ_CP035447.1 Lanthipeptides: ETT52_RS07920_lanthipeptideNZ_CP035449.1 Lanthipeptides: ETT50_RS08255_lanthipeptideNZ_CP035453.1 Lanthipeptides: ETT46_RS08220_lanthipeptideNZ_CP060646.1 Lanthipeptides: H7789_RS07920_lanthipeptideNZ_CP065054.1 Lanthipeptides: I2432_RS09105_lanthipeptideNZ_LRGW01000003.1 Lanthipeptides: AWU01_RS03260_lanthipeptideNZ_LS483298.1 Lanthipeptides: DQM39_RS08650_lanthipeptideNZ_LS483407.1 Lanthipeptides: DQM86_RS08100_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS07865_lanthipeptideNZ_LS483430.1 Lanthipeptides: DQN28_RS07600_lanthipeptide

Lanthipeptides: SPYM3_RS08605_lanthipeptide

GNGVIRTITQGCRMPNNMQV

G+G TIT C PN++ V

GSGWFATITDDC--PNSVFV

36.0% NC_015760.1and 5 others:

Lanthipeptides: SALIVB_RS03310_lanthipeptide

GNGVIRTITQGCRMPNNMQVLFTC

GNGV+ T+T C + + L C

GNGVVLTLTHECNLATWTKKLKCC

36.0% NZ_BMMB01000007.1and 1 other:

NZ_BMMB01000007.1 Lanthipeptides: IEX62_RS15675_lanthipeptide

Lanthipeptides: IEX62_RS15680_lanthipeptide

GNGVIRTITQGCRMPNNMQV

G+G I T+T C PN++ V

GDGWITTLTDDC--PNSIIV

36.0% NZ_CAJHJN010000010.1and 4 others:

NZ_CP066093.1 Lanthipeptides: I6I02_RS06995_lanthipeptideNZ_JACLQK010000029.1 Lanthipeptides: H7U04_RS10750_lanthipeptideNZ_JADPEB010000003.1 Lanthipeptides: I4U26_RS02855_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05170_lanthipeptide

Lanthipeptides: JMZ68_RS08975_lanthipeptide

GNGVIRTITQGCRMPNNMQV

G G TIT C PN++ V

GTGWFATITDDC--PNSVFV

36.0% NZ_NIHT01000008.1and 1 other:

NZ_NIHT01000008.1 Lanthipeptides: CDL23_RS06740_lanthipeptide

Lanthipeptides: CDL23_RS06745_lanthipeptide

GNGVIRTITQGCRMPNNMQV

G+G + TIT C PN++ V

GSGWLPTITDDC--PNSIFV

34.6% NZ_CAAHKQ010000003.1: Lanthipeptides: E9664_RS02165_lanthipeptide

NGVIRTITQGCRMPNNMQVLFTC

NGV +TI+ C + N L C

NGVFKTISHECHL-NTWAFLAIC

27.6% NZ_CP011420.1: Lanthipeptides: VK72_RS10865_lanthipeptide

IRTITQGCRMPNNMQVLF

IRTIT GC ++ F

IRTITAGCDTVCYIKGCF

18.2% NC_017621.1and 16 others:

NZ_CP039462.1 Lanthipeptides: E8M06_RS05390_lanthipeptideNZ_JABTZM010000032.1 Lanthipeptides: HRQ47_RS09675_lanthipeptideNZ_JAEVFQ010000010.1 Lanthipeptides: JNO64_RS06375_lanthipeptideNZ_JAFFHD010000003.1 Lanthipeptides: JN532_RS02075_lanthipeptideNZ_JAGFVG010000007.1 Lanthipeptides: J5581_RS04225_lanthipeptideNZ_JAIJZO010000001.1 Lanthipeptides: K5Q34_RS00965_lanthipeptideNZ_JAIMDS010000024.1 Lanthipeptides: K6V32_RS10650_lanthipeptideNZ_JAJUWV010000001.1 Lanthipeptides: LZF89_RS05505_lanthipeptideNZ_JAMDIS010000017.1 Lanthipeptides: M5P45_RS08180_lanthipeptideNZ_JAMYIU010000001.1 Lanthipeptides: NKE44_RS01780_lanthipeptideNZ_JAMYIX010000001.1 Lanthipeptides: NKE54_RS02675_lanthipeptideNZ_JAMYIY010000001.1 Lanthipeptides: NKE64_RS02785_lanthipeptideNZ_JAMYJP010000014.1 Lanthipeptides: NKE68_RS07350_lanthipeptideNZ_LR738722.1 Lanthipeptides: STREPSUIS_RS03955_lanthipeptideNZ_VZMP01000023.1 Lanthipeptides: F6P50_RS09295_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05700_lanthipeptide

Lanthipeptides: SSUD12_RS06540_lanthipeptide

AGNGVIRTITQGC

AG+G ++T+T+ C

AGSGFVKTLTKDC

18.2% NZ_AQQB01000068.1and 6 others:

NZ_BCEY01000024.1 Lanthipeptides: GOZ53_RS05100_lanthipeptideNZ_BCEZ01000067.1 Lanthipeptides: GOZ55_RS11230_lanthipeptideNZ_BCFC01000053.1 Lanthipeptides: GOZ35_RS07920_lanthipeptideNZ_BCFG01000017.1 Lanthipeptides: GOZ50_RS03220_lanthipeptideNZ_BCFI01000009.1 Lanthipeptides: GOZ54_RS02495_lanthipeptideNZ_CP019557.1 Lanthipeptides: BZG42_RS05725_lanthipeptide

Lanthipeptides: K738_RS01000000110290_lanthipeptide

AGNGVIRTITQGC

AG+G+++T+T+ C

AGSGLVKTLTKDC

16.7% NZ_CP009913.1and 1 other:

NZ_LR793265.1 Lanthipeptides: HV392_RS09820_lanthipeptide

Lanthipeptides: SSAL8618_RS10260_lanthipeptide

ITQGCRMP

+T GCR P

LTHGCRFP

12.2% NZ_LIPB01000002.1: Lanthipeptides: allorf_1135461_1135619_lanthipeptide

QGCRMPNNMQVL

GCR P+ +++L

SGCRRPSAVKIL

MIBiG 3.1 matches for mukA2

23.3% BGC0002110 (QKV49893.1): Lanthipeptide: birimositide

NGVIRTITQGCRMPN

NG T+T+ C+ PN

NGGWCTLTKECQ-PN

21.4% BGC0000517 (BAB04173.1): Lanthipeptide: haloduracin β or haloduracin α

GVIRTITQGCRMPN

G T+T C MP+

GAYCTLTVEC-MPS

mukA_

Leader:

MKKGTQLYLEALEALQEIKVEELDTFIGG

Core:

GGRASNTISSDCRWNSLQAIFSCC

Core with dehydrations:

GGRADhaNDhbIDhaDhaDCysRWNDhaLQAIFDhaCysCys

antiSMASH-DB 4.0 matches for mukA_

100.0% NC_013928.1and 4 others:

Lanthipeptides: SMUNN2025_RS09965_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

75.0% NZ_ALSD01000046.1and 5 others:

Lanthipeptides: SAG0161_RS1000000124770_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G NTIS++CRWNSLQAIFSCC

AGHGVNTISAECRWNSLQAIFSCC

75.0% NZ_CAAHHE010000002.1and 13 others:

Lanthipeptides: E9499_RS02930_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

GG NTIS++CRWNSLQAIF+CC

GGHGVNTISAECRWNSLQAIFTCC

with 50 more sequence matches

70.8% NC_012470.1and 15 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS10120_lanthipeptideNZ_CP018188.1 Lanthipeptides: BSR19_RS11185_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05190_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07305_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09825_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05340_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09695_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS10860_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05070_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04325_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05570_lanthipeptide

Lanthipeptides: SZO_RS10260_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G NTIS++CRWNSLQAIF+CC

AGHGVNTISAECRWNSLQAIFTCC

70.8% NZ_CAAHGW010000010.1and 12 others:

NZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08770_lanthipeptideNZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02160_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08815_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08475_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09025_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08495_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02600_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06670_lanthipeptideNZ_CP035443.1 Lanthipeptides: ETT56_RS07260_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06745_lanthipeptideNZ_NWMU01000024.1 Lanthipeptides: CO197_RS09155_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01580_lanthipeptide

Lanthipeptides: E9435_RS08895_lanthipeptide

GRASNTISSDCRWNSLQAIFSCC

G NTIS++CRWNSLQAIF+CC

GHGVNTISAECRWNSLQAIFTCC

52.0% NZ_JH792236.1and 1 other:

NZ_JH792236.1 Lanthipeptides: IIM_RS26240_lanthipeptide

Lanthipeptides: IIM_RS26245_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G TIS +C NS QAIF+CC

GSGVIKTISHECHMNSWQAIFTCC

52.0% NZ_VDNV01000006.1: Lanthipeptides: FSV44_RS08765_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

GG TIS +CR NS Q +F+CC

GGGVIQTISHECRMNSWQFLFTCC

48.0% NZ_JAEEGA010000010.1: Lanthipeptides: I6N95_RS15660_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G TIS +C NS Q IF+CC

GNGVIKTISHECHMNSWQWIFTCC

45.8% NZ_GL985606.1: Lanthipeptides: HMPREF9062_RS00700_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G +TIS +C +NS IF+CC

GNGVFHTISHECYYNSWAFIFTCC

45.8% NZ_MSRJ01000005.1: Lanthipeptides: BKH06_RS03755_lanthipeptide

TISSDCRWNSLQAIFSCC

TIS +C NS Q IF+CC

TISHECNMNSWQFIFTCC

45.8% NZ_QTVL01000002.1and 5 others:

Lanthipeptides: DWZ44_RS04155_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G TIS +C N+ Q IF+CC

GDGVFRTISHECNMNTWQFIFTCC

44.0% NZ_CP023483.1: Lanthipeptides: CNY62_RS11970_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G A TIS +C N+ Q +F+CC

GNGAIRTISHECHMNTWQFLFTCC

44.0% NZ_CP026729.1: Lanthipeptides: BKKJ1_RS07010_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G TIS +C NS Q +F+CC

GNGVVTTISHECNMNSWQFLFTCC

44.0% NZ_GL882519.1: Lanthipeptides: HMPREF9056_RS03330_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G T+S +C NS Q IF+CC

GNGVYYTLSHECHMNSWQFIFTCC

44.0% NZ_LT732526.1and 1 other:

NZ_LT732526.1 Lanthipeptides: BQ9856_RS23075_lanthipeptide

Lanthipeptides: BQ9856_RS23080_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G TIS +C N+ Q IF+CC

GNGVIKTISHECAMNTWQFIFTCC

42.3% NC_012470.1and 2 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06490_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09840_lanthipeptide

Lanthipeptides: SZO_RS04065_lanthipeptide

ASNTISSDCRWNSLQAIFSCC

A TIS +C NS Q +F+CC

AIKTISHECHMNSWQFLFTCC

42.3% NC_013928.1and 8 others:

Lanthipeptides: SMUNN2025_RS01710_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G A TIS +CR+NS + +CC

GKGAVGTISHECRYNSWAFLATCC

41.7% NZ_CP046956.1: Lanthipeptides: ERJ70_RS03695_lanthipeptide

ASNTISSDCRWNSLQAIFSCC

A +T+S +C N+ Q IF+CC

AISTVSHECHMNTWQFIFTCC

41.7% NZ_CP084014.1and 6 others:

Lanthipeptides: LCQ72_RS00105_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G TIS +C N+ Q +F+CC

GNGVLKTISHECNMNTWQFLFTCC

40.7% NZ_CP046629.1and 3 others:

NZ_FNJX01000002.1 Lanthipeptides: BLR40_RS05025_lanthipeptideNZ_FNZS01000001.1 Lanthipeptides: BMX70_RS03125_lanthipeptideNZ_FOLK01000002.1 Lanthipeptides: BM262_RS05670_lanthipeptide

Lanthipeptides: GPA00_RS05740_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G T+S DC NS Q +F+CC

GSGVVPTVSHDCHMNSWQFLFTCC

40.7% NZ_CP049223.1and 4 others:

Lanthipeptides: G6Z86_RS06445_lanthipeptide

TISSDCRWNSLQAIFSCC

T+S +CR NS Q IF+CC

TVSHECRMNSFQHIFTCC

40.7% NZ_CP069183.1: Lanthipeptides: LLNCDO700_RS13730_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G +TIS +C NS Q +F+CC

GSGVIHTISHECNMNSWQFVFTCC

40.7% NZ_FNUH01000004.1and 1 other:

NZ_FOGM01000011.1 Lanthipeptides: BMX20_RS07220_lanthipeptide

Lanthipeptides: BLU50_RS05815_lanthipeptide

TISSDCRWNSLQAIFSCC

T+S +CR NS Q+IF+CC

TVSYECRMNSWQSIFTCC

40.0% NZ_FOZB01000002.1: Lanthipeptides: BM306_RS07850_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G TIS +C N+ IF+CC

GDGVFRTISHECHMNTWMFIFTCC

40.0% NZ_WBPF01000002.1: Lanthipeptides: F8162_RS00195_lanthipeptide

NTISSDCRWNSLQAIFSCC

+TIS +C WN+ Q +F+CC

DTISHECHWNTWQFLFTCC

38.5% NC_012470.1and 11 others:

Lanthipeptides: SZO_RS04070_lanthipeptide

TISSDCRWNSLQAIFSCC

TIS +C NS Q +F+CC

TISHECHMNSWQFLFTCC

38.5% NZ_JAHBEV010000004.1and 3 others:

NZ_JAHBEX010000010.1 Lanthipeptides: KII86_RS06785_lanthipeptideNZ_JAHBFD010000039.1 Lanthipeptides: KIJ16_RS07340_lanthipeptideNZ_LN890331.1 Lanthipeptides: LEKG_RS02295_lanthipeptide

Lanthipeptides: KII98_RS01100_lanthipeptide

NTISSDCRWNSLQAIFSCC

NT+S +C NS Q +F+CC

NTVSHECNMNSWQFVFTCC

38.5% NZ_NWMU01000024.1and 3 others:

NZ_NWMU01000024.1 Lanthipeptides: CO197_RS09145_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01575_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01570_lanthipeptide

Lanthipeptides: CO197_RS09150_lanthipeptide

TISSDCRWNSLQAIFSCC

TIS +C NS Q F+CC

TISHECHMNSFQFFFTCC

37.0% NZ_CP044492.1and 1 other:

NZ_CP066294.2 Lanthipeptides: IGS65_RS08185_lanthipeptide

Lanthipeptides: FSA31_RS00605_lanthipeptide

TISSDCRWNSLQAIFSCC

T+S +CR NS Q +F+CC

TVSYECRMNSWQHVFTCC

37.0% NZ_CP051645.1and 2 others:

NZ_JAKVFF010000018.1 Lanthipeptides: MKR34_RS11425_lanthipeptideNZ_VDOJ01000018.1 Lanthipeptides: FSV48_RS11975_lanthipeptide

Lanthipeptides: HHJ99_RS13350_lanthipeptide

TISSDCRWNSLQAIFSCC

T+S DC NS Q +F+CC

TVSHDCHMNSFQFVFTCC

34.6% NZ_CP023477.1: Lanthipeptides: CO204_RS01875_lanthipeptide

TISSDCRWNSLQAIFSCC

TIS +CR+NS + +CC

TISHECRYNSWAFLATCC

33.3% NZ_AP025017.1: Lanthipeptides: MANAM107_RS05920_lanthipeptide

TISSDCRWNSLQAIFSCC

TIS +C N+ F+CC

TISHECHLNTWAFAFTCC

33.3% NZ_CP037940.1: Lanthipeptides: EQG49_RS07315_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G T++ +C+ N+ QAI +CC

GSGVIKTLTHECKMNTYQAILTCC

33.3% NZ_CP046304.1: Lanthipeptides: FOC54_RS00030_lanthipeptide

TISSDCRWNSLQAIFSCC

T+S DC N+ Q +F+CC

TVSHDCHMNTFQFMFTCC

33.3% NZ_CP060646.1: Lanthipeptides: H7789_RS06840_lanthipeptide

GGRASNTISSDCR

GG NTIS++CR

GGHGVNTISAECR

33.3% NZ_CP072384.1: Lanthipeptides: J5A65_RS01395_lanthipeptide

TISSDCRWNSLQAIFSCC

T++ +C NS Q F CC

TVTHECHMNSWQWFFGCC

32.0% NZ_CP018188.1and 17 others:

Lanthipeptides: BSR19_RS11180_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G TIS +C N+ + +CC

GNGVFKTISHECHLNTWAFLATCC

32.0% NZ_MSRJ01000005.1: Lanthipeptides: BKH06_RS03750_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G T + +C NS F+CC

GNGVFYTFTHECNTNSFYVAFTCC

30.8% NZ_MSRU01000008.1: Lanthipeptides: BKH03_RS04355_lanthipeptide

TISSDCRWNSLQAIFSCC

+I+ +C NSLQ + +CC

SITHECYMNSLQVLLTCC

29.2% NZ_CP031746.1: Lanthipeptides: DCC27_RS08165_lanthipeptide

NTISSDCRWNSLQAIFSCC

+T++ +C NS Q + +CC

STLTHECHMNSWQGLLTCC

29.2% NZ_CP035428.1: Lanthipeptides: ETT71_RS02820_lanthipeptide

GRASNTISSDCR

G NTIS++CR

GHGVNTISAECR

29.2% NZ_CP083176.1and 4 others:

Lanthipeptides: K9E37_RS06280_lanthipeptide

GGRASNTISSDCRWNSLQAIFSCC

G +T++ +C N+ Q + +CC

GDGVMHTLTHECHMNTWQFLLTCC

26.9% NZ_ALSD01000046.1and 49 others:

Lanthipeptides: SAG0161_RS120605_lanthipeptide

TISSDCRWNSLQAIFSCC

TIS +C N+ + +CC

TISHECHLNTWAFLATCC

26.9% NZ_CAAHKQ010000003.1: Lanthipeptides: E9664_RS02165_lanthipeptide

TISSDCRWNSLQAIFSCC

TIS +C N+ + CC

TISHECHLNTWAFLAICC

26.9% NZ_CP060646.1: Lanthipeptides: H7789_RS06845_lanthipeptide

TISSDCRWNSLQAIFSCC

TIS +C N+ ++ +CC

TISHECHLNTWASLATCC

20.8% NZ_CP065430.1: Lanthipeptides: allorf_1216392_1216607_lanthipeptide

NTISSDCRWNSLQ

+ S C W +LQ

EAVGSTCLWGTLQ

20.0% NZ_LR134406.1: Lanthipeptides: EL272_RS00695_lanthipeptide

ISSDCRWNSLQAIFSCC

+ +C N++ +F+CC

FTHECNTNTMTQLFTCC

19.4% NZ_CP034248.1: Lanthipeptides: EIM92_RS14995_lanthipeptide

TISSDCRWNSL

TIS +C +NS+

TISHECHYNSV

17.6% NZ_CM000748.1and 1 other:

NZ_JAIPUK010000011.1 Lanthipeptides: K9P71_RS26815_lanthipeptide

Lanthipeptides: BTHUR0003_RS30910_lanthipeptide

NTISSDCRWNSLQA

T++ DC WN A

ETLTKDCPWNMPVA

17.6% NZ_CP036100.1and 1 other:

NZ_CP072062.1 Lanthipeptides: J5V93_RS29280_lanthipeptide

Lanthipeptides: EXW47_RS29185_lanthipeptide

NTISSDCRWNSLQA

T++ DC WN A

ETVTKDCPWNVPVA

14.7% NZ_CAKMMP010000011.1and 5 others:

Lanthipeptides: L6H98_RS19925_lanthipeptide

TISSDCRWNSL

T+S +C +NS+

TVSHECHYNSV

14.7% NZ_CM000731.1and 2 others:

NZ_CP043834.1 Lanthipeptides: F0362_RS30375_lanthipeptideNZ_NVOB01000050.1 Lanthipeptides: CON62_RS29235_lanthipeptide

Lanthipeptides: BCERE0020_RS28875_lanthipeptide

NTISSDCRWNSLQA

T++ DC W A

ETLTKDCPWKQPAA

14.7% NZ_JH792312.1and 1 other:

NZ_QNRN01000010.1 Lanthipeptides: DET63_RS17570_lanthipeptide

Lanthipeptides: IIG_RS24665_lanthipeptide

NTISSDCRWN

T++ DC WN

ETLTKDCPWN

MIBiG 3.1 matches for mukA_

20.8% BGC0002111 (EVG22_32245): Lanthipeptide: andalusicin A or andalusicin B

GRASNTISSDC

G ++TIS++C

GAWASTISNNC

20.8% BGC0002111 (multiple genes): Lanthipeptide: andalusicin A or andalusicin B

GRASNTISSDC

G ++TIS++C

GVWASTISNNC

10.3% BGC0001229 (SBI_06990): Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

TISSDCRWN

T+S +C+ N

TLSKECQPN

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

mukA1 - Class II

Cleavage pHMM score: 4.60

RODEO score: 0

Monoisotopic mass: 2701.2 Da

Molecular weight: 2703.1 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2721.1 Da N = 1; 2739.1 Da N = 2

mukA2 - Class II

Cleavage pHMM score: 4.60

RODEO score: 0

Monoisotopic mass: 2669.3 Da

Molecular weight: 2671.1 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2689.2 Da N = 1

mukA3 - Class II

Cleavage pHMM score: 4.60

RODEO score: 0

Monoisotopic mass: 2701.2 Da

Molecular weight: 2703.1 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2721.1 Da N = 1; 2739.1 Da N = 2

mukA_ - Class II

Cleavage pHMM score: 1.70

RODEO score: 0

Monoisotopic mass: 2467.1 Da

Molecular weight: 2468.7 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2486.7 Da N = 1; 2504.8 Da N = 2; 2522.8 Da N = 3