BGC0000539 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000539 (Staphylococcus warneri)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-ii	1	11,740	nukacin ISK-1	ribosomal:RiPP:Lanthipeptide	100%

BGC0000539 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 11,740 nt. (total: 11,740 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 11,741
Label		BGC0000539

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000539	1.00	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000626	0.36	RiPP	thuricin	Bacillus thuringiensis
BGC0000532	0.32	RiPP	mutacin II	Streptococcus mutans
BGC0002630	0.31	RiPP	thatisin	Lysobacter antibioticus
BGC0000554	0.31	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001787	0.29	RiPP	suicin 3908	Streptococcus suis
BGC0000521	0.29	RiPP	lacticin 481	Lactococcus lactis subsp. lactis
BGC0002698	0.28	RiPP	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000528	0.28	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000562	0.28	RiPP	variacin	Kocuria varians

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000539	1.00	RiPP	nukacin ISK-1	Staphylococcus warneri
BGC0000626	0.69	RiPP	thuricin	Bacillus thuringiensis
BGC0000532	0.65	RiPP	mutacin II	Streptococcus mutans
BGC0002630	0.64	RiPP	thatisin	Lysobacter antibioticus
BGC0000554	0.64	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001787	0.63	RiPP	suicin 3908	Streptococcus suis
BGC0000521	0.63	RiPP	lacticin 481	Lactococcus lactis subsp. lactis
BGC0002698	0.62	RiPP	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000528	0.62	RiPP	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000562	0.61	RiPP	variacin	Kocuria varians

Similar known gene clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for nukM

nukA

Leader:

MENSKVMKDIEVANLLEEVQEDELNEVLGA

Core:

KKKSGVIPTVSHDCHMNSFQFVFTCCS

Core with dehydrations:

KKKDhaGVIPDhbVDhaHDCysHMNDhaFQFVFDhbCysCysDha

antiSMASH-DB 4.0 matches for nukA

100.0% NZ_CP051645.1and 2 others:

NZ_JAKVFF010000018.1 Lanthipeptides: MKR34_RS11425_lanthipeptideNZ_VDOJ01000018.1 Lanthipeptides: FSV48_RS11975_lanthipeptide

Lanthipeptides: HHJ99_RS13350_lanthipeptide

KKKSGVIPTVSHDCHMNSFQFVFTCCS

92.6% NZ_CP046304.1: Lanthipeptides: FOC54_RS00030_lanthipeptide

KKKSGVIPTVSHDCHMNSFQFVFTCCS

KKKSGVIPTVSHDCHMN+FQF+FTCCS

KKKSGVIPTVSHDCHMNTFQFMFTCCS

85.2% NZ_CP046629.1and 3 others:

NZ_FNJX01000002.1 Lanthipeptides: BLR40_RS05025_lanthipeptideNZ_FNZS01000001.1 Lanthipeptides: BMX70_RS03125_lanthipeptideNZ_FOLK01000002.1 Lanthipeptides: BM262_RS05670_lanthipeptide

Lanthipeptides: GPA00_RS05740_lanthipeptide

KKKSGVIPTVSHDCHMNSFQFVFTCCS

KK SGV+PTVSHDCHMNS+QF+FTCCS

KKGSGVVPTVSHDCHMNSWQFLFTCCS

with 58 more sequence matches

74.1% NZ_CP069183.1: Lanthipeptides: LLNCDO700_RS13730_lanthipeptide

KKKSGVIPTVSHDCHMNSFQFVFTCCS

K SGVI T+SH+C+MNS+QFVFTCCS

KGGSGVIHTISHECNMNSWQFVFTCCS

74.1% NZ_JAHBEV010000004.1and 3 others:

NZ_JAHBEX010000010.1 Lanthipeptides: KII86_RS06785_lanthipeptideNZ_JAHBFD010000039.1 Lanthipeptides: KIJ16_RS07340_lanthipeptideNZ_LN890331.1 Lanthipeptides: LEKG_RS02295_lanthipeptide

Lanthipeptides: KII98_RS01100_lanthipeptide

KKSGVIPTVSHDCHMNSFQFVFTCCS

+KSGVI TVSH+C+MNS+QFVFTCC+

RKSGVINTVSHECNMNSWQFVFTCCA

70.4% NZ_NWMU01000024.1and 3 others:

NZ_NWMU01000024.1 Lanthipeptides: CO197_RS09145_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01575_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01570_lanthipeptide

Lanthipeptides: CO197_RS09150_lanthipeptide

KSGVIPTVSHDCHMNSFQFVFTCCS

K+GV T+SH+CHMNSFQF FTCCS

KNGVFKTISHECHMNSFQFFFTCCS

66.7% NC_012470.1and 2 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06490_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09840_lanthipeptide

Lanthipeptides: SZO_RS04065_lanthipeptide

KSGVIPTVSHDCHMNSFQFVFTCCS

K+G I T+SH+CHMNS+QF+FTCCS

KNGAIKTISHECHMNSWQFLFTCCS

66.7% NC_012470.1and 11 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06485_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05185_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05180_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09835_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09830_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05350_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05345_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05065_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05060_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05580_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05575_lanthipeptide

Lanthipeptides: SZO_RS04070_lanthipeptide

KSGVIPTVSHDCHMNSFQFVFTCCS

K+GV T+SH+CHMNS+QF+FTCCS

KNGVFKTISHECHMNSWQFLFTCCS

66.7% NZ_JH792236.1and 1 other:

NZ_JH792236.1 Lanthipeptides: IIM_RS26240_lanthipeptide

Lanthipeptides: IIM_RS26245_lanthipeptide

SGVIPTVSHDCHMNSFQFVFTCCS

SGVI T+SH+CHMNS+Q +FTCCS

SGVIKTISHECHMNSWQAIFTCCS

63.0% NZ_CP049223.1and 4 others:

NZ_CP049225.1 Lanthipeptides: G6Z85_RS06555_lanthipeptideNZ_CP049228.1 Lanthipeptides: G6Z83_RS06555_lanthipeptideNZ_JAKWZB010000003.1 Lanthipeptides: MMO78_RS01405_lanthipeptideNZ_PNGO01000002.1 Lanthipeptides: CJ224_RS02730_lanthipeptide

Lanthipeptides: G6Z86_RS06445_lanthipeptide

KKKSGVIPTVSHDCHMNSFQFVFTCC

+ GV+PTVSH+C MNSFQ +FTCC

RWWQGVLPTVSHECRMNSFQHIFTCC

63.0% NZ_GL882519.1: Lanthipeptides: HMPREF9056_RS03330_lanthipeptide

SGVIPTVSHDCHMNSFQFVFTCCS

+GV T+SH+CHMNS+QF+FTCCS

NGVYYTLSHECHMNSWQFIFTCCS

63.0% NZ_JAEEGA010000010.1: Lanthipeptides: I6N95_RS15660_lanthipeptide

SGVIPTVSHDCHMNSFQFVFTCCS

+GVI T+SH+CHMNS+Q++FTCCS

NGVIKTISHECHMNSWQWIFTCCS

63.0% NZ_VDNV01000006.1: Lanthipeptides: FSV44_RS08765_lanthipeptide

SGVIPTVSHDCHMNSFQFVFTCCS

GVI T+SH+C MNS+QF+FTCCS

GGVIQTISHECRMNSWQFLFTCCS

59.3% NZ_CP023483.1: Lanthipeptides: CNY62_RS11970_lanthipeptide

SGVIPTVSHDCHMNSFQFVFTCCS

+G I T+SH+CHMN++QF+FTCCS

NGAIRTISHECHMNTWQFLFTCCS

59.3% NZ_CP044492.1and 1 other:

NZ_CP066294.2 Lanthipeptides: IGS65_RS08185_lanthipeptide

Lanthipeptides: FSA31_RS00605_lanthipeptide

KKKSGVIPTVSHDCHMNSFQFVFTCC

+ GV+PTVS++C MNS+Q VFTCC

RWWQGVVPTVSYECRMNSWQHVFTCC

59.3% NZ_CP046956.1: Lanthipeptides: ERJ70_RS03695_lanthipeptide

GVIPTVSHDCHMNSFQFVFTCC

G I TVSH+CHMN++QF+FTCC

GAISTVSHECHMNTWQFIFTCC

59.3% NZ_LT732526.1and 1 other:

NZ_LT732526.1 Lanthipeptides: BQ9856_RS23075_lanthipeptide

Lanthipeptides: BQ9856_RS23080_lanthipeptide

SGVIPTVSHDCHMNSFQFVFTCCS

+GVI T+SH+C MN++QF+FTCCS

NGVIKTISHECAMNTWQFIFTCCS

59.3% NZ_MSRJ01000005.1: Lanthipeptides: BKH06_RS03755_lanthipeptide

GVIPTVSHDCHMNSFQFVFTCCS

GV+ T+SH+C+MNS+QF+FTCCS

GVVTTISHECNMNSWQFIFTCCS

55.6% NZ_AP025017.1: Lanthipeptides: MANAM107_RS05920_lanthipeptide

SGVIPTVSHDCHMNSFQFVFTCCS

+GVI T+SH+CH+N++ F FTCCS

NGVITTISHECHLNTWAFAFTCCS

55.6% NZ_CP026729.1: Lanthipeptides: BKKJ1_RS07010_lanthipeptide

SGVIPTVSHDCHMNSFQFVFTCCS

+GV+ T+SH+C+MNS+QF+FTCC

NGVVTTISHECNMNSWQFLFTCCG

55.6% NZ_CP031746.1: Lanthipeptides: DCC27_RS08165_lanthipeptide

GVIPTVSHDCHMNSFQFVFTCCS

GVI T++H+CHMNS+Q + TCCS

GVISTLTHECHMNSWQGLLTCCS

55.6% NZ_CP072384.1: Lanthipeptides: J5A65_RS01395_lanthipeptide

GVIPTVSHDCHMNSFQFVFTCC

GV+PTV+H+CHMNS+Q+ F CC

GVVPTVTHECHMNSWQWFFGCC

55.6% NZ_FNUH01000004.1and 1 other:

NZ_FOGM01000011.1 Lanthipeptides: BMX20_RS07220_lanthipeptide

Lanthipeptides: BLU50_RS05815_lanthipeptide

GVIPTVSHDCHMNSFQFVFTCC

GV+PTVS++C MNS+Q +FTCC

GVVPTVSYECRMNSWQSIFTCC

55.6% NZ_FOZB01000002.1: Lanthipeptides: BM306_RS07850_lanthipeptide

GVIPTVSHDCHMNSFQFVFTCCS

GV T+SH+CHMN++ F+FTCCS

GVFRTISHECHMNTWMFIFTCCS

51.9% NZ_ALSD01000046.1and 49 others:

NZ_CAAHGW010000010.1 Lanthipeptides: E9435_RS08890_lanthipeptideNZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS02935_lanthipeptideNZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08685_lanthipeptideNZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08680_lanthipeptideNZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05700_lanthipeptideNZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08730_lanthipeptideNZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08725_lanthipeptideNZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08980_lanthipeptideNZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08975_lanthipeptideNZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01070_lanthipeptideNZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09265_lanthipeptideNZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09260_lanthipeptideNZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08765_lanthipeptideNZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08760_lanthipeptideNZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08915_lanthipeptideNZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08910_lanthipeptideNZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02170_lanthipeptideNZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09655_lanthipeptideNZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03455_lanthipeptideNZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03450_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08825_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08820_lanthipeptideNZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03170_lanthipeptideNZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02470_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08470_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08465_lanthipeptideNZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09580_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09035_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09030_lanthipeptideNZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08495_lanthipeptideNZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08490_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08505_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08500_lanthipeptideNZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06790_lanthipeptideNZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06785_lanthipeptideNZ_CM001076.1 Lanthipeptides: SDD27957_RS04310_lanthipeptideNZ_CM001076.1 Lanthipeptides: SDD27957_RS04305_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02595_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02590_lanthipeptideNZ_CP035428.1 Lanthipeptides: ETT71_RS02815_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06680_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06675_lanthipeptideNZ_CP035443.1 Lanthipeptides: ETT56_RS07265_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS105315_lanthipeptideNZ_LR793258.1 Lanthipeptides: HV369_RS03145_lanthipeptideNZ_LR793258.1 Lanthipeptides: HV369_RS03140_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06755_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06750_lanthipeptideNZ_LT545678.1 Lanthipeptides: BJR96_RS07040_lanthipeptide

Lanthipeptides: SAG0161_RS120605_lanthipeptide

KSGVIPTVSHDCHMNSFQFVFTCCS

K+GV T+SH+CH+N++ F+ TCCS

KNGVFKTISHECHLNTWAFLATCCS

51.9% NZ_CP037940.1: Lanthipeptides: EQG49_RS07315_lanthipeptide

KKSGVIPTVSHDCHMNSFQFVFTCC

K SGVI T++H+C MN++Q + TCC

KGSGVIKTLTHECKMNTYQAILTCC

51.9% NZ_CP084014.1and 6 others:

NZ_CP084014.1 Lanthipeptides: LCQ72_RS00100_lanthipeptideNZ_CP084014.1 Lanthipeptides: LCQ72_RS00095_lanthipeptideNZ_CP094679.1 Lanthipeptides: K5I24_RS13105_lanthipeptideNZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12415_lanthipeptideNZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12410_lanthipeptideNZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12405_lanthipeptide

Lanthipeptides: LCQ72_RS00105_lanthipeptide

SGVIPTVSHDCHMNSFQFVFTCC

+GV+ T+SH+C+MN++QF+FTCC

NGVLKTISHECNMNTWQFLFTCC

51.9% NZ_QTVL01000002.1and 5 others:

NZ_QTVL01000002.1 Lanthipeptides: DWZ44_RS04150_lanthipeptideNZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14340_lanthipeptideNZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14335_lanthipeptideNZ_QUKU01000003.1 Lanthipeptides: DXC27_RS02940_lanthipeptideNZ_QUKU01000003.1 Lanthipeptides: DXC27_RS02935_lanthipeptide

Lanthipeptides: DWZ44_RS04155_lanthipeptide

SGVIPTVSHDCHMNSFQFVFTCC

GV T+SH+C+MN++QF+FTCC

DGVFRTISHECNMNTWQFIFTCC

51.9% NZ_WBPF01000002.1: Lanthipeptides: F8162_RS00195_lanthipeptide

GVIPTVSHDCHMNSFQFVFTCCS

G T+SH+CH N++QF+FTCCS

GQFDTISHECHWNTWQFLFTCCS

48.1% NZ_CAAHKQ010000003.1: Lanthipeptides: E9664_RS02165_lanthipeptide

KSGVIPTVSHDCHMNSFQFVFTCCS

K+GV T+SH+CH+N++ F+ CCS

KNGVFKTISHECHLNTWAFLAICCS

48.1% NZ_CP018188.1and 17 others:

NZ_CP018188.1 Lanthipeptides: BSR19_RS11175_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07300_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07295_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09705_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09700_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09300_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09295_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09300_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09295_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06585_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06580_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06585_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06580_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05120_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05115_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04335_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04330_lanthipeptide

Lanthipeptides: BSR19_RS11180_lanthipeptide

SGVIPTVSHDCHMNSFQFVFTCCS

+GV T+SH+CH+N++ F+ TCCS

NGVFKTISHECHLNTWAFLATCCS

48.1% NZ_CP060646.1: Lanthipeptides: H7789_RS06845_lanthipeptide

KSGVIPTVSHDCHMNSFQFVFTCCS

K+GV T+SH+CH+N++ + TCCS

KNGVFKTISHECHLNTWASLATCCS

48.1% NZ_CP083176.1and 4 others:

NZ_JABUHD010000002.1 Lanthipeptides: HRR08_RS05415_lanthipeptideNZ_LSLF01000001.1 Lanthipeptides: AXE72_RS04025_lanthipeptideNZ_PNHB01000001.1 Lanthipeptides: CJ210_RS02800_lanthipeptideNZ_QJVA01000001.1 Lanthipeptides: D0T19_RS02755_lanthipeptide

Lanthipeptides: K9E37_RS06280_lanthipeptide

SGVIPTVSHDCHMNSFQFVFTCC

GV+ T++H+CHMN++QF+ TCC

DGVMHTLTHECHMNTWQFLLTCC

48.1% NZ_GL985606.1: Lanthipeptides: HMPREF9062_RS00700_lanthipeptide

SGVIPTVSHDCHMNSFQFVFTCC

+GV T+SH+C+ NS+ F+FTCC

NGVFHTISHECYYNSWAFIFTCC

48.1% NZ_MSRJ01000005.1: Lanthipeptides: BKH06_RS03750_lanthipeptide

SGVIPTVSHDCHMNSFQFVFTCCS

+GV T +H+C+ NSF FTCCS

NGVFYTFTHECNTNSFYVAFTCCS

44.4% NC_013928.1and 8 others:

NC_013928.1 Lanthipeptides: SMUNN2025_RS01700_lanthipeptideNZ_CP023477.1 Lanthipeptides: CO204_RS01885_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01090_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01080_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01745_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01735_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07575_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07565_lanthipeptide

Lanthipeptides: SMUNN2025_RS01710_lanthipeptide

GVIPTVSHDCHMNSFQFVFTCCS

G + T+SH+C NS+ F+ TCCS

GAVGTISHECRYNSWAFLATCCS

44.4% NZ_CP023477.1: Lanthipeptides: CO204_RS01875_lanthipeptide

GVIPTVSHDCHMNSFQFVFTCCS

G + T+SH+C NS+ F+ TCCS

GTVGTISHECRYNSWAFLATCCS

44.4% NZ_MSRU01000008.1: Lanthipeptides: BKH03_RS04355_lanthipeptide

GVIPTVSHDCHMNSFQFVFTCCS

GV +++H+C+MNS Q + TCCS

GVKWSITHECYMNSLQVLLTCCS

44.1% NZ_FMVM01000006.1and 2 others:

NZ_RIAS01000010.1 Lanthipeptides: EC604_RS18225_lanthipeptideNZ_VEJI01000010.1 Lanthipeptides: FS576_RS22075_lanthipeptide

Lanthipeptides: BLQ13_RS10365_lanthipeptide

KKKSGVIPTVSHDCHMNSF--QFVFTCC

KK GV TVSH+CH NS TCC

KKSGGVFCTVSHECHYNSVSPSSWLTCC

41.9% NZ_CP034248.1: Lanthipeptides: EIM92_RS14995_lanthipeptide

KKKSGVIPTVSHDCHMNSFQ--FVFTCC

GVI T+SH+CH NS TCC

AASGGVICTISHECHYNSVSPAAWATCC

41.2% NZ_CAKMMP010000011.1: Lanthipeptides: L6H98_RS19925_lanthipeptide

KKKSGVIPTVSHDCHMNSF--QFVFTCC

K GV TVSH+CH NS TCC

AKSGGVFCTVSHECHYNSVSPSSWLTCC

40.7% NC_013928.1and 4 others:

NZ_CP023477.1 Lanthipeptides: CO204_RS01880_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01085_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01740_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07570_lanthipeptide

Lanthipeptides: SMUNN2025_RS01705_lanthipeptide

SGVIPTVSHDCHM-NSFQFVFTC

+GVI T++ C M N+ Q +FTC

NGVIRTITQGCRMPNNMQVLFTC

38.2% NZ_CP018620.1and 1 other:

NZ_CP062165.1 Lanthipeptides: JNUCC31_RS16755_lanthipeptide

Lanthipeptides: BS614_RS05680_lanthipeptide

KKKSGVIPTVSHDCHMNSF--QFVFTCC

+ GV TVSH+CH NS TCC

QASGGVFCTVSHECHYNSVSPSSWLTCC

37.0% NC_012470.1and 42 others:

NZ_CAAHGW010000010.1 Lanthipeptides: E9435_RS08895_lanthipeptideNZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS02930_lanthipeptideNZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08675_lanthipeptideNZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05705_lanthipeptideNZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08735_lanthipeptideNZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08985_lanthipeptideNZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01075_lanthipeptideNZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09255_lanthipeptideNZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08770_lanthipeptideNZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08920_lanthipeptideNZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02160_lanthipeptideNZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09650_lanthipeptideNZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03445_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08815_lanthipeptideNZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03175_lanthipeptideNZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02475_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08475_lanthipeptideNZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09585_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09025_lanthipeptideNZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08485_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08495_lanthipeptideNZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS10120_lanthipeptideNZ_CP018188.1 Lanthipeptides: BSR19_RS11185_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05190_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02600_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06670_lanthipeptideNZ_CP035443.1 Lanthipeptides: ETT56_RS07260_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07305_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09825_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05340_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09695_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS10860_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05070_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06745_lanthipeptideNZ_NWMU01000024.1 Lanthipeptides: CO197_RS09155_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04325_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01580_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05570_lanthipeptide

Lanthipeptides: SZO_RS10260_lanthipeptide

IPTVSHDCHMNSFQFVFTCC

+ T+S +C NS Q +FTCC

VNTISAECRWNSLQAIFTCC

37.0% NC_013928.1and 4 others:

NZ_CP023477.1 Lanthipeptides: CO204_RS01890_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS01095_lanthipeptideNZ_CP061071.1 Lanthipeptides: IBL27_RS01750_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07560_lanthipeptide

Lanthipeptides: SMUNN2025_RS09965_lanthipeptide

TVSHDCHMNSFQFVFTCC

T+S DC NS Q +F+CC

TISSDCRWNSLQAIFSCC

33.3% NZ_ALSD01000046.1and 5 others:

NZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06795_lanthipeptideNZ_CM001076.1 Lanthipeptides: SDD27957_RS10995_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS1000000113590_lanthipeptideNZ_LR793258.1 Lanthipeptides: HV369_RS03150_lanthipeptideNZ_LT545678.1 Lanthipeptides: BJR96_RS11590_lanthipeptide

Lanthipeptides: SAG0161_RS1000000124770_lanthipeptide

IPTVSHDCHMNSFQFVFTCC

+ T+S +C NS Q +F+CC

VNTISAECRWNSLQAIFSCC

33.3% NZ_JAFCGV010000005.1: Lanthipeptides: JQI09_RS04275_lanthipeptide

GVIPTVSHDCHMNSFQFVFTCC

GV+ T + +C++ +F FV CC

GVVKTATSECYLGTFAFV--CC

33.3% NZ_LR134406.1: Lanthipeptides: EL272_RS00695_lanthipeptide

GVIPTVSHDCHMNSFQFVFTCC

G I + +H+C+ N+ +FTCC

GSIFSFTHECNTNTMTQLFTCC

33.3% NZ_NIHT01000008.1and 1 other:

NZ_NIHT01000008.1 Lanthipeptides: CDL23_RS06740_lanthipeptide

Lanthipeptides: CDL23_RS06745_lanthipeptide

KKSGVIPTVSHDCHMNSFQFVFTCC

SG +PT++ DC +F CC

NGSGWLPTITDDCP----NSIFVCC

29.6% NZ_CP042289.1and 13 others:

NZ_CP055231.1 Lanthipeptides: allorf_2676924_2677073_lanthipeptideNZ_CP055232.1 Lanthipeptides: allorf_2583654_2583803_lanthipeptideNZ_CP065992.1 Lanthipeptides: allorf_1149357_1149506_lanthipeptideNZ_CP093926.1 Lanthipeptides: allorf_1615586_1615735_lanthipeptideNZ_JABXFL010000001.1 Lanthipeptides: allorf_2753501_2753650_lanthipeptideNZ_JABXFU010000006.1 Lanthipeptides: allorf_1215526_1215675_lanthipeptideNZ_JAHENG010000004.1 Lanthipeptides: allorf_126203_126352_lanthipeptideNZ_KB932612.1 Lanthipeptides: allorf_045411_045560_lanthipeptideNZ_KZ846603.1 Lanthipeptides: allorf_046792_046941_lanthipeptideNZ_LR134297.1 Lanthipeptides: allorf_0210505_0210654_lanthipeptideNZ_VOEC01000022.1 Lanthipeptides: allorf_125681_125830_lanthipeptideNZ_VOEE01000005.1 Lanthipeptides: allorf_44991_45140_lanthipeptideNZ_VOEG01000010.1 Lanthipeptides: allorf_045441_045590_lanthipeptide

Lanthipeptides: allorf_2740138_2740287_lanthipeptide

SGVIPTVSHDCHMNSFQFVF

SG+ H CH N FQ +

SGLFLRAGHFCH-NLFQLLL

29.6% NZ_CP045267.1and 1 other:

NZ_CP045267.1 Lanthipeptides: FDZ14_RS00155_lanthipeptide

Lanthipeptides: FDZ14_RS00155_lanthipeptide

GVIPTVSHDCHMNSFQFVFTCC

GV+ T + +C++ +F F CC

GVVKTATSECYLGTFAFA--CC

29.6% NZ_CP055229.1: Lanthipeptides: allorf_2402172_2402321_lanthipeptide

SGVIPTVSHDCHMNSFQFVF

SG+ H CH N FQ +

SGLFLRAEHFCH-NLFQLLL

29.6% NZ_CP077726.1and 12 others:

NZ_CP077726.1 Lanthipeptides: KTC92_RS18420_lanthipeptideNZ_CP077726.1 Lanthipeptides: KTC92_RS18415_lanthipeptideNZ_CP077726.1 Lanthipeptides: KTC92_RS18410_lanthipeptideNZ_CP077726.1 Lanthipeptides: KTC92_RS18405_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19070_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19065_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19060_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19055_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19050_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19045_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19040_lanthipeptideNZ_CP086248.1 Lanthipeptides: LL036_RS19035_lanthipeptide

Lanthipeptides: KTC92_RS18425_lanthipeptide

SGVIPTVSHDCHMNS

+GVI T +H+C+ NS

NGVITTFTHECYYNS

29.6% NZ_CP086142.1and 3 others:

NZ_CP086142.1 Lanthipeptides: LL065_RS25460_lanthipeptideNZ_CP086142.1 Lanthipeptides: LL065_RS25455_lanthipeptideNZ_CP086142.1 Lanthipeptides: LL065_RS25450_lanthipeptide

Lanthipeptides: LL065_RS25465_lanthipeptide

SGVIPTVSHDCHMNS

GVI T +H+C+ NS

GGVITTFTHECYYNS

25.9% NC_015760.1and 5 others:

NZ_CAJHJN010000010.1 Lanthipeptides: JMZ68_RS09030_lanthipeptideNZ_JACLQK010000036.1 Lanthipeptides: H7U04_RS11500_lanthipeptideNZ_JADPEB010000003.1 Lanthipeptides: I4U26_RS02800_lanthipeptideNZ_JAQCST010000021.1 Lanthipeptides: PGZ09_RS09470_lanthipeptideNZ_OU540596.1 Lanthipeptides: JQ838_RS05640_lanthipeptide

Lanthipeptides: SALIVB_RS03310_lanthipeptide

SGVIPTVSHDCHMNSFQFVFTCC

+GV+ T++H+C++ ++ CC

NGVVLTLTHECNLATWTKKLKCC

25.9% NZ_CP117876.1: Lanthipeptides: PQ460_RS01735_lanthipeptide

GVIPTVSHDCHMNSFQFVFTCC

GV+ T + +C++ + F+ CC

GVVKTATSECYLGTVAFI--CC

21.2% NZ_AP024169.1: Lanthipeptides: bsdtb5_RS06110_lanthipeptide

KSGVIPTVSHDCHMNS

K G PT+S++C N+

KCGGFPTISYECTSNN

21.2% NZ_AP024169.1: Lanthipeptides: bsdtb5_RS06105_lanthipeptide

KSGVIPTVSHDCHMNSF

K G +PT+S++C N+

KCGRMPTISYECTSNNV

20.7% NZ_LR027842.1: Lanthipeptides: E0E39_RS15855_lanthipeptide

KKSGVIPTVSHDCH

+ G + TVS +CH

RTIGAVCTVSWECH

15.2% NZ_AP024169.1: Lanthipeptides: bsdtb5_RS06100_lanthipeptide

KSGVIPTVSHDC

+ G +PT+S++C

RCGAVPTLSYEC

10.7% NZ_QRDO01000002.1: Lanthipeptides: allorf_1060605_1060811_lanthipeptide

HMNSFQFVFTCCS

HM+S Q++ T S

HMSSDQYIATATS

MIBiG 3.1 matches for nukA

11.1% BGC0002111 (EVG22_32245)and 1 other:

BGC0002111 (multiple genes) Lanthipeptide: andalusicin A or andalusicin B

Lanthipeptide: andalusicin A or andalusicin B

TVSHDC

T+S++C

TISNNC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

nukA - Class II

Cleavage pHMM score: 3.80

RODEO score: 0

Monoisotopic mass: 2921.4 Da

Molecular weight: 2923.4 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2941.4 Da N = 1; 2959.4 Da N = 2; 2977.5 Da N = 3