BGC0000547 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000547 (Streptococcus salivarius)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	22,620	High	salivaricin 9	ribosomal:RiPP:Lanthipeptide

BGC0000547 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 22,620 nt. (total: 22,620 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 22,621
Label		BGC0000547

Tailoring functions

Lyases: cyclase

sivM: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000547.5	1.00	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000557.5	0.66	ribosomal	streptococcin A-FF22	Streptococcus pyogenes
BGC0001788.3	0.62	ribosomal	suicin 65	Streptococcus suis
BGC0000526.5	0.62	ribosomal	macedocin	Streptococcus macedonicus
BGC0000521.3	0.62	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000539.5	0.60	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000532.3	0.57	ribosomal	mutacin II	Streptococcus mutans
BGC0000499.3	0.53	ribosomal	butyrivibriocin OR79	Butyrivibrio fibrisolvens
BGC0001210.5	0.52	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.52	ribosomal	thuricin	Bacillus thuringiensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000547.5	1.00	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000557.5	0.66	ribosomal	streptococcin A-FF22	Streptococcus pyogenes
BGC0001788.3	0.62	ribosomal	suicin 65	Streptococcus suis
BGC0000521.3	0.62	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000526.5	0.60	ribosomal	macedocin	Streptococcus macedonicus
BGC0000539.5	0.59	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000532.3	0.57	ribosomal	mutacin II	Streptococcus mutans
BGC0000499.3	0.53	ribosomal	butyrivibriocin OR79	Butyrivibrio fibrisolvens
BGC0001210.5	0.52	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.52	ribosomal	thuricin	Bacillus thuringiensis

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for sivM

sivA

Leader:

MKSTNNQSISEIAAVNSLQEVSMEELDQIIGA

Core:

GNGVVLTLTHECNLATWTKKLKCC

Core with dehydrations:

GNGVVLDhbLDhbHECysNLADhbWDhbKKLKCysCys

antiSMASH-DB 4.0 matches for sivA

100.0%

NC_015760.1and 5 others:

NZ_CAJHJN010000010.1 Lanthipeptides: JMZ68_RS09030_lanthipeptideNZ_JACLQK010000036.1 Lanthipeptides: H7U04_RS11500_lanthipeptideNZ_JADPEB010000003.1 Lanthipeptides: I4U26_RS02800_lanthipeptideNZ_JAQCST010000021.1 Lanthipeptides: PGZ09_RS09470_lanthipeptideNZ_OU540596.1 Lanthipeptides: JQ838_RS05640_lanthipeptide

Lanthipeptides: SALIVB_RS03310_lanthipeptide

GNGVVLTLTHECNLATWTKKLKCC

58.3%

NZ_CP083176.1and 4 others:

NZ_JABUHD010000002.1 Lanthipeptides: HRR08_RS05415_lanthipeptideNZ_LSLF01000001.1 Lanthipeptides: AXE72_RS04025_lanthipeptideNZ_PNHB01000001.1 Lanthipeptides: CJ210_RS02800_lanthipeptideNZ_QJVA01000001.1 Lanthipeptides: D0T19_RS02755_lanthipeptide

Lanthipeptides: K9E37_RS06280_lanthipeptide

GNGVVLTLTHECNLATWTKKLKCC

G+GV+ TLTHEC++ TW L CC

GDGVMHTLTHECHMNTWQFLLTCC

54.2%

NZ_CP084014.1and 6 others:

NZ_CP084014.1 Lanthipeptides: LCQ72_RS00100_lanthipeptideNZ_CP084014.1 Lanthipeptides: LCQ72_RS00095_lanthipeptideNZ_CP094679.1 Lanthipeptides: K5I24_RS13105_lanthipeptideNZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12415_lanthipeptideNZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12410_lanthipeptideNZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12405_lanthipeptide

Lanthipeptides: LCQ72_RS00105_lanthipeptide

GNGVVLTLTHECNLATWTKKLKCC

GNGV+ T++HECN+ TW CC

GNGVLKTISHECNMNTWQFLFTCC

with 62 more sequence matches

Only the first 10 are displayed here.

52.0%

NZ_CP018188.1and 17 others:

NZ_CP018188.1 Lanthipeptides: BSR19_RS11175_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07300_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07295_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09705_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09700_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09300_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09295_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09300_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09295_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06585_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06580_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06585_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06580_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05120_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05115_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04335_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04330_lanthipeptide

Lanthipeptides: BSR19_RS11180_lanthipeptide

GNGVVLTLTHECNLATWTKKLKCC

GNGV T++HEC+L TW CC

GNGVFKTISHECHLNTWAFLATCC

52.0%

NZ_CP026729.1:

Lanthipeptides: BKKJ1_RS07010_lanthipeptide

GNGVVLTLTHECNLATWTKKLKCC

GNGVV T++HECN+ +W CC

GNGVVTTISHECNMNSWQFLFTCC

50.0%

NZ_AP025017.1:

Lanthipeptides: MANAM107_RS05920_lanthipeptide

NGVVLTLTHECNLATWTKKLKCC

NGV+ T++HEC+L TW CC

NGVITTISHECHLNTWAFAFTCC

50.0%

NZ_CP031746.1:

Lanthipeptides: DCC27_RS08165_lanthipeptide

NGVVLTLTHECNLATWTKKLKCC

+GV+ TLTHEC++ +W L CC

DGVISTLTHECHMNSWQGLLTCC

50.0%

NZ_CP072384.1:

Lanthipeptides: J5A65_RS01395_lanthipeptide

GNGVVLTLTHECNLATWTKKLKCC

G GVV T+THEC++ +W CC

GRGVVPTVTHECHMNSWQWFFGCC

50.0%

NZ_QTVL01000002.1and 5 others:

NZ_QTVL01000002.1 Lanthipeptides: DWZ44_RS04150_lanthipeptideNZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14340_lanthipeptideNZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14335_lanthipeptideNZ_QUKU01000003.1 Lanthipeptides: DXC27_RS02940_lanthipeptideNZ_QUKU01000003.1 Lanthipeptides: DXC27_RS02935_lanthipeptide

Lanthipeptides: DWZ44_RS04155_lanthipeptide

GNGVVLTLTHECNLATWTKKLKCC

G+GV T++HECN+ TW CC

GDGVFRTISHECNMNTWQFIFTCC

48.1%

NZ_CP037940.1:

Lanthipeptides: EQG49_RS07315_lanthipeptide

GNGVVLTLTHECNLATWTKKLKCC

G+GV+ TLTHEC + T+ L CC

GSGVIKTLTHECKMNTYQAILTCC

48.0%

NZ_CP045267.1and 1 other:

NZ_CP045267.1 Lanthipeptides: FDZ14_RS00155_lanthipeptide

Lanthipeptides: FDZ14_RS00155_lanthipeptide

GNGVVLTLTHECNLATWTKKLKCC

G+GVV T T EC L T+ CC

GDGVVKTATSECYLGTFA--FACC

48.0%

NZ_GL882519.1:

Lanthipeptides: HMPREF9056_RS03330_lanthipeptide

GNGVVLTLTHECNLATWTKKLKCC

GNGV TL+HEC++ +W CC

GNGVYYTLSHECHMNSWQFIFTCC

48.0%

NZ_LT732526.1and 1 other:

NZ_LT732526.1 Lanthipeptides: BQ9856_RS23075_lanthipeptide

Lanthipeptides: BQ9856_RS23080_lanthipeptide

GNGVVLTLTHECNLATWTKKLKCC

GNGV+ T++HEC + TW CC

GNGVIKTISHECAMNTWQFIFTCC

MIBiG 4.0 matches for sivA

23.3%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

NGVVLTLTHEC

NG TLT EC

NGGWCTLTKEC

21.4%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

GVVLTLTHEC

G TLT EC

GAYCTLTVEC

allorf_08465_08653

Leader:

MSPNSPITLVAVVSA

Core:

IPGIERRISYSGRGLANSTNCSKTCSRRFVNLISSCALYWLFVNCSG

Core with dehydrations:

IPGIERRIDhaYDhaGRGLANDhaDhbNCysDhaKDhbCysDhaRRFVNLIDhaDhaCysALYWLFVNCysDhaG

antiSMASH-DB 4.0 matches for allorf_08465_08653

19.1%

NC_013947.1:

Lanthipeptides: SNAS_RS17185_lanthipeptide

ERRISYSGRGLANSTNCSK

E R Y A STNC+K

ELRELYIHEATAQSTNCTK

14.0%

NZ_JADWPD010000048.1:

Lanthipeptides: I4Q55_RS46280_lanthipeptide

RGLANSTNCSKTCSRRFV

G ++NC+ TC RF

EGCTTTSNCTITCYTRFA

allorf_08730_08867

Leader:

MSFAFLIEICDMARIGM

Core:

ASCSDIVNTFVQNFSCIRIPTLSDMLLT

Core with dehydrations:

ADhaCysDhaDIVNDhbFVQNFDhaCysIRIPDhbLDhaDMLLDhb

antiSMASH-DB 4.0 matches for allorf_08730_08867

28.6%

NZ_CP085297.1:

Lanthipeptides: allorf_03653_03829_lanthipeptide

NFSCIRIPTLSDMLL

+F CI+I L MLL

SFKCIKISPLWLMLL

21.4%

NZ_CP040938.1:

Lanthipeptides: allorf_0462507_0462617_lanthipeptide

NTFVQNFSCIR

N +QN SC+R

NKHLQNNSCLR

14.3%

NZ_CP096019.1:

Lanthipeptides: allorf_1451265_1451483_lanthipeptide

NTFVQNFSCIRIP

+++ + SC+R P

SSYAEEVSCLRTP

MIBiG 4.0 matches for allorf_08730_08867

21.4%

BGC0000503.5 (cinA):

Lanthipeptide: cinnamycin

SCSDIVNTFV

SCS TFV

SCSFGPFTFV

14.3%

BGC0000563.4 (AEA03263.1):

Lanthipeptide: venezuelin

IVNTFVQNFSC

++NT SC

LLNTVCIGISC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

sivA - Class II

Cleavage pHMM score: 5.20

RODEO score: 0

Monoisotopic mass: 2559.3 Da

Molecular weight: 2561.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2579.1 Da N = 1

allorf_08465_08653 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 5018.6 Da

Molecular weight: 5021.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 5039.8 Da N = 1; 5057.8 Da N = 2; 5075.8 Da N = 3; 5093.8 Da N = 4; 5111.8 Da N = 5; 5129.9 Da N = 6

allorf_08730_08867 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 2961.5 Da

Molecular weight: 2963.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2981.4 Da N = 1; 2999.5 Da N = 2; 3017.5 Da N = 3; 3035.5 Da N = 4; 3053.5 Da N = 5