Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000551.1:
Cluster 1RiPP16728

BGC0000551, sapB biosynthetic gene cluster from Streptomyces coelicolor. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: SapB
SMILES string: Copy to clipboard
Exact molecular mass: 2026.97 Da (None)
Molecular activity: Surfactant

Class-specific details

Biosynthetic class(es):
RiPP subclass:
Lantipeptide (cyclic)
Peptides in this cluster:
RiPP core peptide sequence(s): TGSRASLLLCGDSSLSITTCN
Leader peptide length: 21
Follower peptide length: -1
Cleavage recognition site sequence(s): DVETGS
Peptidase(s) involved in precursor cleavage:

Gene cluster description

sapB (BGC0000551). Gene Cluster 1. Biosynthetic class = RiPP. GenBank AL645882. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Detailed annotation

SCO6682 leader / core peptide, putative Class III


Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Gene expression correlated with compound production
Contact for this cluster:Joanne Willey (Hofstra University)

Literature references

1. Kodani S et al. (2004) The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor. Proc Natl Acad Sci U S A 101(31):11448-53. doi: