BGC0000551 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000551 (Streptomyces coelicolor A3(2))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-iii	1	6,728	SAL-2242	RiPP:Lanthipeptide	66%

BGC0000551 - Region 1 - lanthipeptide-class-iii

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Location: 1 - 6,728 nt. (total: 6,728 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 6,729
Label		BGC0000551

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000551.1	1.00	RiPP	SapB	Streptomyces coelicolor A3(2)
BGC0000563.1	0.32	RiPP	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000501.1	0.30	RiPP	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000519.1	0.30	RiPP	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000496.1	0.30	RiPP	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000546.1	0.23	RiPP	SAL-2242	Streptomyces albidoflavus
BGC0000554.1	0.22	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000513.1	0.20	RiPP	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001484.1	0.19	Other	2'-chloropentostatin, 2'-amino-2'-deoxyadenosine	Actinomadura sp. ATCC 39365
BGC0000518.1	0.18	RiPP	informatipeptin	Streptomyces viridochromogenes DSM 40736

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000551.1	1.00	RiPP	SapB	Streptomyces coelicolor A3(2)
BGC0000563.1	0.66	RiPP	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000501.1	0.64	RiPP	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000519.1	0.63	RiPP	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000496.1	0.63	RiPP	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000546.1	0.57	RiPP	SAL-2242	Streptomyces albidoflavus
BGC0000554.1	0.54	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000513.1	0.52	RiPP	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001484.1	0.51	Other	2'-chloropentostatin, 2'-amino-2'-deoxyadenosine	Actinomadura sp. ATCC 39365
BGC0000518.1	0.50	RiPP	informatipeptin	Streptomyces viridochromogenes DSM 40736

Similar known gene clusters

Lanthipeptide predictions

Lanthipeptide(s) for SCO6681

SCO6682

Leader:

MNLFDLQSMETPKEEAMGDVE

Core:

TGSRASLLLCGDSSLSITTCN

Core with dehydrations:

DhbGDhaRADhaLLLCysGDDhaDhaLDhaIDhbDhbCysN

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

SCO6682 - Class III

Cleavage pHMM score: 32.20

RODEO score: 0

Monoisotopic mass: 1954.0 Da

Molecular weight: 1955.2 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 1973.2 Da N = 1; 1991.2 Da N = 2; 2009.2 Da N = 3; 2027.3 Da N = 4; 2045.3 Da N = 5; 2063.3 Da N = 6