Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000606.1:
Cluster 1RiPP114244

BGC0000606, lactazole biosynthetic gene cluster from Streptomyces lactacystinaeus. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: lactazole

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Thiopeptide

Gene cluster description

lactazole (BGC0000606). Gene Cluster 1. Biosynthetic class = RiPP. GenBank AB820694. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Detailed annotation

lazA leader / core peptide, putative Class I
MSDITASRVESLDLQDLDLSELTVTSLRDTVALPE - NGADhaWGDhaCDhaCQADhaDhaDhaCAQPQDM

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Literature references

1. Hayashi S et al. (2014) Genome mining reveals a minimum gene set for the biosynthesis of 32-membered macrocyclic thiopeptides lactazoles. Chem Biol 21(5):679-88. doi: 10.1016/j.chembiol.2014.03.008. Epub