Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000615.1:
Cluster 1RiPP135080

BGC0000615, TP-1161 biosynthetic gene cluster from Nocardiopsis sp. TFS65-07. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: TP-1161
Molecular formula: C50H47N15O13S3
Exact molecular mass: 1161.2619 Da (None)
Molecular activity: Antibacterial
Molecular target: ribosome

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Thiopeptide (cyclic)
Peptides in this cluster:
ADO67770.1
RiPP core peptide sequence(s): CTTSGCACSSSSSST
Leader peptide length: 33
Peptidase(s) involved in precursor cleavage:

Gene cluster description

TP-1161 (BGC0000615). Gene Cluster 1. Biosynthetic class = RiPP. GenBank HM467197. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Detailed annotation

tpaA leader / core peptide, putative Class I
MNKDIDLSAIEISDLISETEQSDDALSQ - VMAADhaCDhbDhbDhbGCACDhaDhaDhaDhaDhaDhaDhb
tpaX leader / core peptide, putative Class I
MNHEIDLSAIEISDLVHEVEQGEDTFSQ - VMAADhaCVGDhbACDhbCDhaDhaDhbDhaDhaDhaDhb

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Sergey Zotchev (Norwegian University of Science and Technology)

Literature references

1. Engelhardt K et al. (2010) Production of a new thiopeptide antibiotic, TP-1161, by a marine Nocardiopsis species. Appl Environ Microbiol 76(15):4969-76. doi: 10.1128/AEM.00741-10. Epub