BGC0000615 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000615 (Nocardiopsis sp. TFS65-07)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	thiopeptide	1	35,080	berninamycin A	RiPP	66%

BGC0000615 - Region 1 - thiopeptide

Download region GenBank file

Download region SVG

Location: 1 - 35,080 nt. (total: 35,080 nt) Show pHMM detection rules used

Region on contig edge.

thiopeptide: ((YcaO or TIGR03604) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

MIBiG comparison

KnownClusterBlast

Thiopeptides

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 35,081
Label		BGC0000615

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000615.1	1.00	RiPP	TP-1161	Nocardiopsis sp. TFS65-07
BGC0000628.1	0.25	RiPP	lactocillin	Lactobacillus paragasseri JV-V03
BGC0001146.1	0.24	RiPP	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001145.1	0.23	RiPP	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000613.1	0.22	RiPP	thiomuracin A	Nonomuraea sp. Bp3714-39
BGC0001860.1	0.22	RiPP	thiomuracin	Thermobispora bispora DSM 43833
BGC0000605.1	0.21	RiPP	GE37468	Streptomyces sp. ATCC 55365
BGC0001472.1	0.20	RiPP	berninamycin A	Streptomyces bernensis
BGC0000603.1	0.19	RiPP	cyclothiazomycin	Streptomyces hygroscopicus
BGC0001753.1	0.18	RiPP	radamycin, globimycin	Streptomyces globisporus subsp. globisporus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000615.1	1.00	RiPP	TP-1161	Nocardiopsis sp. TFS65-07
BGC0000607.1	0.71	RiPP	micrococcin P1	Macrococcus caseolyticus
BGC0000628.1	0.58	RiPP	lactocillin	Lactobacillus paragasseri JV-V03
BGC0001146.1	0.57	RiPP	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001145.1	0.56	RiPP	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000613.1	0.55	RiPP	thiomuracin A	Nonomuraea sp. Bp3714-39
BGC0001860.1	0.55	RiPP	thiomuracin	Thermobispora bispora DSM 43833
BGC0000605.1	0.53	RiPP	GE37468	Streptomyces sp. ATCC 55365
BGC0001472.1	0.52	RiPP	berninamycin A	Streptomyces bernensis
BGC0000603.1	0.51	RiPP	cyclothiazomycin	Streptomyces hygroscopicus

Similar known gene clusters

Thiopeptide predictions

Thiopeptide(s)

tpaA

Leader:

MNKDIDLSAIEISDLISETEQSDDALSQVMAA

Core:

SCTTTGCACSSSSSST

Core with dehydrations:

DhaCysDhbDhbDhbGCysACysDhaDhaDhaDhaDhaDhaDhb

tpaX

Leader:

MNHEIDLSAIEISDLVHEVEQGEDTFSQVMAA

Core:

SCVGTACTCSSTSSST

Core with dehydrations:

DhaCysVGDhbACysDhbCysDhaDhaDhbDhaDhaDhaDhb

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Types:

Type I: Featuring genes encoding indolic acid side ring (series e)
Type II: Featuring the gene coding for quinaldic acid moiety formation (series a, b, and c)
Type III: No genes for synthesizing L-Trp derivatives (series d)

Thiopeptides

Core peptide predictions

tpaA

Putative Type III

Cleavage pHMM score: 22.40

RODEO score: 30

Monoisotopic mass: 1468.5 Da

Molecular weight: 1469.5 Da

Predicted peptide features:
Central ring: pyridine trisubstituted

Macrocycle: 35-member

Alternative weights: (assuming N unmodified Ser/Thr residues); 1487.5 Da N = 1; 1505.6 Da N = 2; 1523.6 Da N = 3; 1541.6 Da N = 4; 1559.6 Da N = 5; 1577.6 Da N = 6; 1595.7 Da N = 7; 1613.7 Da N = 8; 1631.7 Da N = 9; 1649.7 Da N = 10; 1667.7 Da N = 11

tpaX

Putative Type III

Cleavage pHMM score: 23.70

RODEO score: 25

Monoisotopic mass: 1480.5 Da

Molecular weight: 1481.6 Da

Predicted peptide features:
Central ring: pyridine trisubstituted

Alternative weights: (assuming N unmodified Ser/Thr residues); 1499.6 Da N = 1; 1517.6 Da N = 2; 1535.6 Da N = 3; 1553.7 Da N = 4; 1571.7 Da N = 5; 1589.7 Da N = 6; 1607.7 Da N = 7; 1625.7 Da N = 8; 1643.8 Da N = 9; 1661.8 Da N = 10