Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000628.1:
Cluster 1RiPP113800

BGC0000628, lactocillin biosynthetic gene cluster from Lactobacillus gasseri. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: lactocillin
SMILES string: Copy to clipboard
Molecular formula: C51H45N13O10S7
Average molecular mass: 1224.15184 Da
Molecular activity: Antibacterial
Molecular target: Binds to the 50S ribosomal subunit, Protein synthesis inhibitor

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Thiopeptide (cyclic)
Peptides in this cluster:
HMPREF0514_11728
RiPP core peptide sequence(s): SCTTCTCCCSCCA
Leader peptide length: 45
Follower peptide length: 13
Peptidase(s) involved in precursor cleavage:

Gene cluster description

lactocillin (BGC0000628). Gene Cluster 1. Biosynthetic class = RiPP. GenBank ACGO02000004, positions 9724-22493. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:K, n, o, c, k, -, o, u, t, , s, t, u, d, i, e, s
MIxS-compliance:Unknown
Contact for this cluster:Mohamed Donia (Princeton University)

Literature references

1. Donia MS et al. (2014) A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics. Cell 158(6):1402-1414. doi: 10.1016/j.cell.2014.08.032.