BGC0000628 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000628 (Lactobacillus paragasseri JV-V03)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	thiopeptide	1	13,800

BGC0000628 - Region 1 - thiopeptide

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Location: 1 - 13,800 nt. (total: 13,800 nt) Show pHMM detection rules used

Region on contig edge.

thiopeptide: ((YcaO or TIGR03604) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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MIBiG

MIBiG comparison

KnownClusterBlast

Thiopeptides

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 13,801
Label		BGC0000628

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000628.1	1.00	RiPP	lactocillin	Lactobacillus paragasseri JV-V03
BGC0001146.1	0.24	RiPP	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000607.1	0.22	RiPP	micrococcin P1	Macrococcus caseolyticus
BGC0001145.1	0.22	RiPP	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000605.1	0.19	RiPP	GE37468	Streptomyces sp. ATCC 55365
BGC0001640.1	0.19	RiPP	kocurin	Kocuria rosea
BGC0000603.1	0.17	RiPP	cyclothiazomycin	Streptomyces hygroscopicus
BGC0001707.1	0.16	RiPP	nosiheptide	Streptomyces sp.
BGC0000613.1	0.16	RiPP	thiomuracin A	Nonomuraea sp. Bp3714-39
BGC0001860.1	0.16	RiPP	thiomuracin	Thermobispora bispora DSM 43833

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000628.1	1.00	RiPP	lactocillin	Lactobacillus paragasseri JV-V03
BGC0001146.1	0.57	RiPP	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000607.1	0.55	RiPP	micrococcin P1	Macrococcus caseolyticus
BGC0001145.1	0.55	RiPP	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000605.1	0.52	RiPP	GE37468	Streptomyces sp. ATCC 55365
BGC0001640.1	0.50	RiPP	kocurin	Kocuria rosea
BGC0000603.1	0.48	RiPP	cyclothiazomycin	Streptomyces hygroscopicus
BGC0001707.1	0.47	RiPP	nosiheptide	Streptomyces sp.
BGC0000613.1	0.47	RiPP	thiomuracin A	Nonomuraea sp. Bp3714-39
BGC0001860.1	0.46	RiPP	thiomuracin	Thermobispora bispora DSM 43833

Similar known gene clusters

No matches found.

Thiopeptide predictions

Thiopeptide(s)

HMPREF0514_11728

Leader:

MKGGVKMKDLFDIDEKSLENLDLGDFKILDSEDLSEKDEKSILGA

Core:

SCTTCTCCCSCC

Core with dehydrations:

DhaCysDhbDhbCysDhbCysCysCysDhaCysCys

HMPREF0514_11728

Cleaved off residues:

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Types:

Type I: Featuring genes encoding indolic acid side ring (series e)
Type II: Featuring the gene coding for quinaldic acid moiety formation (series a, b, and c)
Type III: No genes for synthesizing L-Trp derivatives (series d)

Thiopeptides

Core peptide predictions

HMPREF0514_11728

Putative Type III

Cleavage pHMM score: 7.10

RODEO score: 26

Monoisotopic mass: 1216.3 Da

Molecular weight: 1217.5 Da

Predicted peptide features:
Central ring: pyridine trisubstituted

Macrocycle: 26-member

Alternative weights: (assuming N unmodified Ser/Thr residues); 1235.5 Da N = 1; 1253.5 Da N = 2; 1271.5 Da N = 3; 1289.6 Da N = 4; 1307.6 Da N = 5