BGC0000653: pentalenolactone biosynthetic gene cluster from Streptomyces arenae
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Location: 1 - 21,694 nt. (total: 21,694 nt).
This entry is originally from NCBI GenBank HQ292065.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000653
Short description pentalenolactone biosynthetic gene cluster from Streptomyces arenae
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • terpene (Unknown)
Loci
HQ292065.1
via
Compounds
  • pentalenolactone
Species Streptomyces arenae [taxonomy]
References
Chemical products information
pentalenolactone [synonyms: (1R,4aR,6aR,7S,9aS)-7,8-dimethyl-2-oxospiro[4,4a,6a,7-tetrahydropentaleno[1,6a-c]pyran-1,2'-oxirane]-5-carboxylic acid, Arenaemycin E] Evidence: NMR [1], Mass spectrometry [1]
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C15H16O5
Chemical database entries
PubCHEM
ChEBI
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADO85568.1
 <1 - 2707 (-) putative WD-repeat containing protein
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    • ADO85569.1
    • pntR
    		 2888 - 3349 (-) PntR
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      • ADO85570.1
      • gapR
      		 3490 - 4494 (+) GapR
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        • ADO85571.1
        • pntM
        		 4673 - 5869 (+) Other
        • Other
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        • ADO85572.1
        • pntH
        		 6009 - 6860 (+) PntH
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          • ADO85573.1
          • pntG
          		 6918 - 8372 (+) PntG
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            • ADO85574.1
            • pntF
            		 8473 - 9321 (+) PntF
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              • ADO85575.1
              • pntE
              		 9324 - 11093 (+) Oxidase
              • Oxidation
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              • ADO85576.1
              • pntD
              		 11130 - 12029 (+) Dehydration|Oxidation
              • Dehydration
              • Oxidation
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              • ADO85577.1
              • pntB
              		 12026 - 13039 (+) PntB
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                • ADO85578.1
                • pntA
                		 13164 - 14177 (+) PntA
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                  • ADO85579.1
                  • pntI
                  		 14292 - 15665 (+) Oxidase
                  • Oxidation
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                  • ADO85580.1
                  		 15804 - 16871 (-) ornithine cyclodeaminase
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                    • ADO85581.1
                    		 17047 - 18513 (-) nonribosomal peptide synthetase
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                      • ADO85582.1
                      		 18517 - 19272 (-) thioesterase II
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                        • ADO85583.1
                        		 19269 - 20930 (-) nonribosomal peptide synthetase
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                          • ADO85584.1
                          		 20923 - >21692 (-) nonribosomal peptide synthetase
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                            Biosynthesis information

                            No biosynthesis information available for this record.

                            Annotation changelog

                            Entry version: 5

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2024-05-14
                            MIBiG v4 annotathon
                            • (ID: P75FRHHCFPTCPYSP65VDVPHW)
                            • (ID: C5S3TPG4JF6AA26MUEX57QI3)
                            • (ID: QLI3AUYAC552MNLPXGXAKUIB)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 4

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-10-07
                            Update chemical activity to schema version 2.11
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Updated bioactivity data
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2019-10-16
                            Updated compound(s) information (NPAtlas curation)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2015-06-12
                            Submitted
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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