BGC0000662

BGC0000662: grixazone A biosynthetic gene cluster from Streptomyces griseus subsp. griseus NBRC 13350

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Location: 4,957,169 - 4,972,074 nt. (total: 14,906 nt).
This entry is originally from NCBI GenBank AP009493.1.

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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General

Compounds

Genes

History

KnownClusterBlast

General information about the BGC

MIBiG accession	BGC0000662
Short description	grixazone A biosynthetic gene cluster from Streptomyces griseus subsp. griseus NBRC 13350
Status	Minimal annotation: yes A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s) Completeness: Unknown Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)	Terpene
Loci	NCBI GenBank: AP009493.1
Compounds	grixazone A
Species	Streptomyces griseus subsp. griseus NBRC 13350 [taxonomy]
References	GriC and GriD constitute a carboxylic acid reductase involved in grixazone biosynthesis in Streptomyces griseus. Suzuki H et al., J Antibiot (Tokyo) (2007) PMID:17617696 Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350. Ohnishi Y et al., J Bacteriol (2008) PMID:18375553 Phenolic lipids synthesized by type III polyketide synthase confer penicillin resistance on Streptomyces griseus. Funabashi M et al., J Biol Chem (2008) PMID:18364359 Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus. Hirano S et al., Microbiology (Reading) (2008) PMID:18310036

Chemical products information

grixazone A

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C₁₈H₁₅N₃O₆S₁

Chemical database entries
PubCHEM

List of genes involved in compound(s) production

Identifiers	Position	Product	Extra
SGR_4238 BAG21067.1 griT	4957169 - 4958371 (-)	putative LuxR-family transcriptional regulator	copy AA seq copy Nt seq
SGR_4239 BAG21068.1 griS	4958513 - 4959136 (+)	GriS protein	copy AA seq copy Nt seq
SGR_4240 BAG21069.1 griR	4959179 - 4960102 (+)	transcriptional regulator	copy AA seq copy Nt seq
SGR_4241 BAG21070.1 griA	4960332 - 4961711 (+)	putative FAD-dependent oxygenase	copy AA seq copy Nt seq
SGR_4242 BAG21071.1 griB	4961820 - 4963172 (+)	putative grixazone transporter	copy AA seq copy Nt seq
SGR_4243 BAG21072.1 griC	4963351 - 4964409 (+)	arylcarboxylate reductase component	copy AA seq copy Nt seq
SGR_4244 BAG21073.1 griD	4964409 - 4965779 (+)	arylcarboxylate reductase component	copy AA seq copy Nt seq
SGR_4245 BAG21074.1 griE	4965832 - 4966221 (+)	copper chaperon	copy AA seq copy Nt seq
SGR_4246 BAG21075.1 griF	4966261 - 4967181 (+)	ortho-aminophenol oxidase	copy AA seq copy Nt seq
SGR_4247 BAG21076.1 griG	4967311 - 4968669 (+)	putative 3,4-AHBA transporter	copy AA seq copy Nt seq
SGR_4248 BAG21077.1 griH	4968644 - 4969834 (-)	3,4-AHBA synthase	copy AA seq copy Nt seq
SGR_4249 BAG21078.1 griI	4969910 - 4970734 (-)	aldolase	copy AA seq copy Nt seq
SGR_4250 BAG21079.1 griJ	4970791 - 4972074 (-)	putative aspartokinase homologue	copy AA seq copy Nt seq

Annotation changelog

MIBiG version	Submitter	Notes
1.0	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Submitted
2.0	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Migrated from v1.4
3.0	Hidden contributor (ID: SJG3CBEHSM6A3I74YXLH6GLA, no GDPR consent given). Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Fix product metadata Add publication Updated bioactivity data
3.1	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Update chemical activity to schema version 2.11

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