BGC0000679: diazepinomicin biosynthetic gene cluster from Micromonospora sp. M42
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Location: 255,998 - 303,913 nt. (total: 47,916 nt).
This entry is originally from NCBI GenBank KK037233.1.

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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000679
Short description diazepinomicin biosynthetic gene cluster from Micromonospora sp. M42
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • terpene (Unknown)
Loci
KK037233.1
255998 - 303913
via
Compounds
  • diazepinomicin
Species Micromonospora sp. M42 [taxonomy]
References
Chemical products information
diazepinomicin Evidence:
Copy SMILES
C28H34N2O4
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • MCBG_00164
  • EWM63031.1
 255998 - 258175 (-) membrane protein
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    • MCBG_00165
    • EWM63032.1
    		 258777 - 260792 (+) LigA protein
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      • MCBG_00166
      • EWM63033.1
      		 260847 - 263534 (-) LigA protein
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        • MCBG_00167
        • EWM63034.1
        		 263936 - 265024 (+) polyprenyl synthetase
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          • MCBG_00168
          • EWM63035.1
          		 265039 - 266079 (+) mevalonate kinase
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            • MCBG_00169
            • EWM63036.1
            		 266069 - 267109 (+) diphosphomevalonate decarboxylase
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              • MCBG_00170
              • EWM63037.1
              		 267106 - 268215 (+) phosphomevalonate kinase
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                • MCBG_00171
                • EWM63038.1
                		 268212 - 269294 (+) isopentenyl-diphosphate delta-isomerase, type 2
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                  • MCBG_00172
                  • EWM63039.1
                  		 269291 - 270346 (+) hydroxymethylglutaryl-coenzyme A reductase
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                    • MCBG_00173
                    • EWM63040.1
                    		 270349 - 271524 (+) hydroxymethylglutaryl-CoA synthase
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                      • MCBG_00174
                      • EWM63041.1
                      		 271561 - 272466 (+) hypothetical protein
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                        • MCBG_00175
                        • EWM63042.1
                        		 272590 - 273690 (+) two-component system sensor kinase
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                          • MCBG_00176
                          • EWM63043.1
                          		 273687 - 274349 (+) two-component system response regulator
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                            • MCBG_00177
                            • EWM63044.1
                            		 274541 - 274936 (+) hypothetical protein
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                              • MCBG_00178
                              • EWM63045.1
                              		 275000 - 275455 (+) hypothetical protein
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                                • MCBG_00179
                                • EWM63046.1
                                		 275452 - 277470 (+) multicopper oxidase
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                                  • MCBG_00180
                                  • EWM63047.1
                                  		 277467 - 277871 (+) glyoxalase
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                                    • MCBG_00181
                                    • EWM63048.1
                                    		 278013 - 278480 (-) hypothetical protein
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                                      • MCBG_00182
                                      • EWM63049.1
                                      		 278575 - 280539 (-) anthranilate synthase, phenazine specific
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                                        • MCBG_00183
                                        • EWM63050.1
                                        		 280793 - 282058 (+) aspartate kinase 2
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                                          • MCBG_00184
                                          • EWM63051.1
                                          		 282074 - 282895 (+) fructose-bisphosphate aldolase
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                                            • MCBG_00185
                                            • EWM63052.1
                                            		 282927 - 284030 (+) 3-dehydroquinate synthase
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                                              • MCBG_00186
                                              • EWM63053.1
                                              		 284056 - 284817 (+) metal-dependent hydrolase
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                                                • MCBG_00187
                                                • EWM63054.1
                                                		 284871 - 286130 (+) hypothetical protein
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                                                  • MCBG_00188
                                                  • EWM63055.1
                                                  		 286141 - 287331 (+) monooxygenase
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                                                    • MCBG_00189
                                                    • EWM63056.1
                                                    		 287331 - 288116 (+) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
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                                                      • MCBG_00190
                                                      • EWM63057.1
                                                      		 288155 - 288829 (+) isochorismatase
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                                                        • MCBG_00191
                                                        • EWM63058.1
                                                        		 288841 - 289542 (+) oxidoreductase, short chain dehydrogenase/reductase family
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                                                          • MCBG_00192
                                                          • EWM63059.1
                                                          		 289535 - 290275 (-) LigA protein
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                                                            • MCBG_00193
                                                            • EWM63060.1
                                                            		 290471 - 290806 (+) integral membrane protein
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                                                              • MCBG_00194
                                                              • EWM63061.1
                                                              		 290803 - 292482 (+) sodium:solute symporter
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                                                                • MCBG_00195
                                                                • EWM63062.1
                                                                		 292495 - 294141 (+) FAD-binding monooxygenase
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                                                                  • MCBG_00196
                                                                  • EWM63063.1
                                                                  		 294220 - 295461 (+) phospho-2-dehydro-3-deoxyheptonate aldolase
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                                                                    • MCBG_00197
                                                                    • EWM63064.1
                                                                    		 295636 - 296745 (+) hypothetical protein
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                                                                      • MCBG_00198
                                                                      • EWM63065.1
                                                                      		 296926 - 298407 (+) hypothetical protein
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                                                                        • MCBG_00199
                                                                        • EWM63066.1
                                                                        		 298507 - 298854 (+) transcriptional regulator, PadR family
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                                                                          • MCBG_00200
                                                                          • EWM63067.1
                                                                          		 298851 - 299882 (+) hypothetical protein
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                                                                            • MCBG_00201
                                                                            • EWM63068.1
                                                                            		 299879 - 300160 (-) acyl-CoA oxidase
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                                                                              • MCBG_00202
                                                                              • EWM63069.1
                                                                              		 300336 - 302015 (-) acyl-CoA oxidase
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                                                                                • MCBG_00203
                                                                                • EWM63070.1
                                                                                		 302192 - 303913 (+) ABC transporter ATP-binding protein
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                                                                                  Biosynthesis information
                                                                                  Annotation changelog

                                                                                  Entry version: 4

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2022-10-07
                                                                                  Update chemical activity to schema version 2.11
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                  Entry version: 3

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2022-09-15
                                                                                  Updated bioactivity data
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                  Entry version: 2

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2019-10-16
                                                                                  Migrated from v1.4
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  2019-10-16
                                                                                  Updated compound(s) information (NPAtlas curation)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                  Entry version: 1

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2015-06-12
                                                                                  Submitted
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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