Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000819.1:
Cluster 1NRP / Alkaloid147884

BGC0000819, paraherquamide biosynthetic gene cluster from Penicillium fellutanum. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: parahequamide A
SMILES string: Copy to clipboard
Molecular formula: C28H35N3O5
Exact molecular mass: 493.2577 Da (None)
Molecular activity: Antifungal

Class-specific details

Biosynthetic class(es):
NRP / Alkaloid
Other (cyclic)
Thioesterase type:
None
Release / cyclization type:
Reductive release

Nonribosomal peptide synthetases:
phqB (AGA37269.1)
Module 1
A specificity: 4-Methylproline
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 2
A specificity: Tryptophan
Evidence for specificity: Structure-based inference
C domain subtype: N/A
Scaffold-modifying domain: Other
Alkaloid subclass:
Pyrrole/pyrrolidine

Gene cluster description

paraherquamide (BGC0000819). Gene Cluster 1. Biosynthetic class = NRP/Alkaloid. GenBank JQ708195, positions 1-47884. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Fengan Yu (University of Michigan)

Literature references

1. Li S et al. (2012) Comparative analysis of the biosynthetic systems for fungal bicyclo[2.2.2]diazaoctane indole alkaloids: the (+)/(-)-notoamide, paraherquamide and malbrancheamide pathways. Medchemcomm 3(8):987-996. doi: 10.1039/C2MD20029E.